For his ground-breaking chemical biological research, a VICI-grant has been awarded to Mario van der Stelt, professor of Molecular physiology at Leiden University. In a new research line, he aims to discover binding sites for new medicines against inflammations in the brain.

Mario van der Stelt has been appointed Professor of Molecular Physiology at the Leiden Institute of Chemistry with effect from 1 November 2017.

Media in the Netherlands and abroad reported extensively about the drug research led by Leiden chemist Mario van der Stelt. In this research, Van der Stelt shows which unwanted side-effects a French drug candidate has.

Mario van der Stelt (Head of the department of Molecular Physiology at the Leiden Institute of Chemistry) has received the Young Investigator Award from the International Cannabinoid Research Society during the annual meeting of the society in Montreal, Canada. The Young Investigator Award was given…

On Friday May 3rd 2013 NWO has announced that Dr. Mario van der Stelt, Division of Bio-Organic Synthesis (LIC) and Dr. Laura Heitman, Division of Medicinal Chemistry (LACDR), have been awarded with an ECHO-STIP grant for their project, entitled: “Novel target engagement biomarkers for better drug ca…

China wordt steeds assertiever in zijn relaties met andere landen, maar achter dit beeld gaat een opmerkelijk diverse maatschappij en politieke realiteit schuil die tal van aanknopingspunten biedt voor samenwerking en verdere integratie van China in de wereld. In China een gids voor de 21e eeuw past…

Grants awarded to molecular physiology research

Het CPL biedt opleidingen voor hogeropgeleide professionals: starters, ervaren professionals en leidinggevenden.

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Cancer is the leading cause of death in the Netherlands, and, with over 100 different types of cancer, it’s not a simple disease. Today, skin, breast, lung, prostate and colon cancer are the most diagnosed forms. Therefore, the discovery and development of new drugs has the ability to significantly…

De decentralisaties van de zorg aan langdurig zieken en ouderen, jeugdzorg, en werk en inkomen die vanaf 2015 zijn doorgevoerd in Nederland hebben geleid tot een transitie van een centraal naar een lokaal stelsel van zorg en welzijn. Deze transitie beoogt zorg en ondersteuning dichter bij de inwoners…

In november 2023 is Anne Fleur van Veenstra, wetenschappelijk directeur van TNO Vector, benoemd tot bijzonder hoogleraar ‘Governance van data en algoritmen voor stedelijk beleid’.

Inaugural lecture

Multiple Sclerosis, Parkinson’s and Alzheimer’s disease are the most common neurodegenerative disorders. Unfortunately, no effective treatments are currently available to halt the progression of these neuroinflammatory diseases [1].

Activity-based protein profiling (ABPP, also termed chemical proteomics), is one of the pillars of chemical biology, and at LED3 we have taken it to the next level. ABPP allows the assessment of protein function in live cells and tissues, which means that the activity of a complete protein family can…

The drug BIA 10-2474 inhibits fatty acid amide hydrolase (FAAH), a lipase that degrades a specific endocannabinoid. On the basis of this activity, BIA 10-2474 was being developed as a potential treatment for anxiety and pain. In a phase 1 trial of the drug, one subject died, and four others suffered…

The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…

The aim of the research described in this thesis was to use structure-based design to optimise multiple properties of aryl sulfoxide monoacylglycerol lipase inhibitors as anti-inflammatory analgesics.

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In Democratie en totalitarisme zijn de invloedrijkste opstellen van de Franse denker Claude Lefort samengebracht. Lefort laat overtuigend zien dat de kwetsbaarheid van de democratie juist ook haar kracht is. Voor democratie is essentieel dat de macht als ‘lege plaats’ verschijnt. Zij mag slechts tijdelijk…

Our department aims to educate academic professionals who are prepared for the future of law and organization.

Inaugural lecture

Molecular Physiology is a research group at the Leiden Institute of Chemistry dedicated to the design, synthesis and application of chemical tools to study important biological and biomedical questions. The group is headed by Prof. Dr. Mario van der Stelt and includes the research lines of Assistant…

Conference

Chemical tools to monitor drug-target engagement of endogenously expressed protein kinases are highly desirable for preclinical target validation in drug discovery. Here, we describe a chemical genetics strategy to selectively study target engagement of endogenous kinases.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

N-acylethanolamines (NAEs), including N-arachidonoylethanolamine (anandamide, AEA), N-palmitoylethanolamine (PEA) and N-oleoylethanolamine (OEA), are signaling lipids that play an important role in different physiological process.

Diacylglycerol lipases (DAGLα and DAGLβ) convert diacylglycerol to the endocannabinoid 2-arachidonoylglycerol. Our understanding of DAGL function has been hindered by a lack of chemical probes that can perturb these enzymes in vivo.

The Cell Observatory is run by several people some of which have multiple roles. To identify whom to contact for what issue please refer to the list below

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.

The cannabinoid CB2 receptor (CB2R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous compounds have been developed and widely used to target CB2R, their selectivity, molecular mode of action and pharmacokinetic properties have…

This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.

Endocannabinoids are lipid messengers that modulate various physiological functions by activating the cannabinoid CB1 and CB2 receptors. While the metabolism of endocannabinoids and their action at the CB receptors is fairly well studied, the molecular mechanisms governing their release and transport…

Our students and public and private organisations have much to offer each other. To connect students with organisations, FGGA facilitates this through an internship and traineeship platform: TRAIL.

Covid-19 is een disruptieve ontwikkeling die hier en nu veel vraagt van zorgprofessionals, bestuurders en managers. Hoewel de crisis nog volop bezig is, is nu al duidelijk dat het Coronavirus een blijvende impact zal hebben op zorginstellingen en fundamentele vragen oproept over hoe we onze zorg optimaal…

Platform Opleiding, Onderwijs en Organisatie Ltd (PLATO). PLATO is committed to learning, learning in schools, learning in work environments, learning in life and life.

This PhD-thesis presents a study on micron-sized particles, so-called colloids. By controlling the chemical and physical properties of these particles, such as the interparticle interaction and the particles’ shape, colloids can act as building blocks that self-assembly into larger structures.

Promotor: Prof.dr. M.L. van Hecke

An overview of awards and prizes granted to our staff and students in 2017, as well as special appointments and royal distinctions.

Research and education at the Leiden Institute of Chemistry is overseen by the Institute Board. The Board and representatives of the two research themes form the Management Team. The Scientific Council (WERA), the Institute Council (I-Raad) and the platform for PhDs and post-doctoral co-workers (LIC73)…

Mattias Brand defended his thesis on 10 April 2019

Synthetic microswimmers take an important place within the interdisciplinary field of active soft matter.

Policy studies and interventions in the field of Youth

Study information, Proefstuderen

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt