Promotores: Prof.dr. H. van Veen & Prof.dr. W. de Boer (Wageningen University)

The relative simplicity of the bacterial cell, short generation times and well defined and inexpensive culturing conditions have significantly contributed to our understanding of many complex biological systems. Yet the workings of the bacterial genome, seemingly impossibly compressed within a tiny…

This work has described synthetic strategies towards well-defined structures resembling capsular polysaccharide (CPS) fragments, CPS mimics, teichoic acid (TA) fragments as well as a third-generation ring-closing tandem metathesis (RCM) linker to better exploit the potential of automated synthesis.

Authoritative and cutting-edge, Bacterial Chromatin: Methods and Protocols aims to be useful as an up-to-date reference work for scholars in the bacterial chromatin field, those entering the field from adjacent research fields, and scientists in the eukaryotic chromatin field.

Authoritative and cutting-edge, Bacterial Chromatin: Methods and Protocols, Second Edition aims to be a useful up-to-date reference work for researchers currently in the field and to those entering the field.

The main focus of the thesis is the discovery and development of novel inhibitors of bacterial metallo-β-lactamases (MBLs).

Mechanical forces are known to play an important role in bacterial colonies. In this dissertation, we study the self-organization at various stages of growing bacterial colonies, and focus on the mechanical effects of cell growth.

Bacterial chemosensory arrays are protein assemblies that are the key structural and functional component for motile bacteria to sense their internal or environmental chemical signals.

Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.

Promotores: J.A.van Veen, P.L.G.Klinkhamer. Co-promotor: E.E.Kuramae

Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.

This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…

This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.

Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

CONCLUSION: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells. Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in…

What is the relation between the experience and the act of exclusion?

Whether a microbe is beneficial or harmful to a plant can now be predicted with high accuracy thanks to bacLIFE. This bioinformatic tool with an intuitive interface makes it much easier to unlock the secrets of bacterial genomes. A group of Leiden biologists presented it in Nature Communications.

Mapping of bacterial genomes to combat infectious diseases

An international team with researchers from Leiden revealed how a bacterium repurposed an internal system to control its movements. Movement control is very important in host invasion, which can lead to disease. Publication on 27 April in Nature Communications.

The consequences of social tendencies for the legislation and institutions in the fields of social security, the labor market policy and pension reform are examined in this multdisciplinary research program..

Why does social anxiety increase in adolescence and how does it grow out of control in some adolescents?

Can we determine the 3D structure of a chemotaxis core complex using single-particle reconstructions via cryo-EM?

This project aims at studying the social media reception of African publications as covered by the most important “altmetric” sources.

This thesis, conducted in the framework of ERC Starting grant project BABYLON (PI: Caroline Waerzeggers), presents an investigation into Babylonian society, focusing on the city of Borsippa during Neo-Babylonian and early Persian rule (c. 620-484 BCE).

This dissertation takes an important step in understanding the phenomenon of non-take-up of social support and what it means for contemporary social policies.

Why do some children confront social challenges with confidence, whereas others experience difficulties? What is the role of child temperament and child emotional dispositions? What is the role of parenting? This project aims to shed light on the mechanisms explaining shyness and confidence in response…

Are there any differences in gaze behavior between high and low socially anxious individuals? What factors influence the relation between social anxiety and gaze behavior?

A neurobiological perspective on individual differences in social competence

The studies outlined in this volume explore how connectedness continues to change Africa and how Africa continues to shape the social life of connections.

Do you have to be able to say everything on Twitter and Facebook? Is Instagram morally obliged to remove photos from attacks? Should we allow the terrorist group to recruit new members on the internet?

At the Young Academy Leiden, we care deeply about fostering social safety at our university. Increasing social safety is of particular importance to early career scholars as they often find themselves in a vulnerable position without a permanent contract, or with a dependence on superiors for progressing…

Helping people, groups and policymakers navigate the social transitions of our time.

Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.

As part of the ZonMW Antibiotics resistance funding program, the LACDR cluster Systems Pharmacology was awarded €455.255 for a research project to develop novel clinical biomarkers for bacterial infections.

At FGGA, we want our staff to feel safe in all respects. We therefore strive to create a work environment where we treat each other with respect, where we promote inclusion and where we speak up if we experience or witness unsafety.

Pieter de la Court, Wassenaarseweg 52, 2333 AK, Leiden

Social Science Matters is an online variant on London’s famous Speakers’ Corner – a platform for the researchers in the various disciplines in the Faculty of Social and Behavioural Sciences to react to the news. This soapbox gives our social scientists an opportunity to voice their opinions on current…

Efficiently responding to others’ emotions has great survival value, especially for social species, such as primates, who establish close, long-term bonds with group members. The closest living relatives to humans are the chimpanzee and the bonobo. Studying these species, and comparing them on the exact…

The [A]Social Creatures Lab is an interdisciplinary research lab that focuses on understanding social interaction with and between artificial creatures. Researchers and students from the Media Technology group collaborate in it.

Social anxiety disorder is one of the most common disorders in children and young people. Social anxiety is characterized by excessive fear and avoidance of social situations. The primary fear in children with social anxiety is that they will be negatively judged by others. To date, the most frequently…

There are several ways to stay up to date via social media.

Social anxiety runs in families, but the neurobiology underlying this genetic vulnerability is until now largely unknown. The unique Leiden Family Lab study on Social Anxiety Disorder (LFLSAD) aims to broaden our knowledge with respect to this genetic susceptibility.

Social Citizenship & Migration (SCM) is one of the nine interdisciplinary programmes launched by Leiden University in 2020. It is led by the Faculties of Governance and Global Affairs, Law, Humanities, and Social Science.

Serious forms of anxiety concerning other people’s opinions can hinder teenagers at school in social interactions or carrying out tasks. Psychologist Anne Miers is looking for ways to reduce this so-called ‘social anxiety’.

Innovation plays an essential role in firms' competitiveness and long-term success. It varies from different types, ranging from run-of-the-mill innovation that brings incremental changes to existing technologies to radical innovation that breaks from existing trajectories.

The [a]social creatures lab focusses on understanding social interaction with and between artificial creatures.

This interdisciplinary research project explores several adaptive machine learning methods which can give insight into the interaction between human and machine. The ultimate goal is open and natural communication between humans and AI that should result in mutual trust, cooperation and coordination…

At Leiden University’s Faculty of Social and Behavioural Sciences we keep in touch with our alumni in various ways.