Health workers have always sought ways to fight disease in vulnerable groups in the population. It is now clear that such research also benefits more prosperous countries. African worm infections and innovative thermometers have shown Leiden researchers how to fight diseases of affluence and keep health…

They can play a role in metabolic disorders and can break down tough plant fibers: β-glycosidases are enzymes that play many roles in nature. Fredj Ben Bdira changed these enzymes in order to enhance the production of clean energy and to improve the treatment of patients with metabolic diseases.

Identifying natural plant-associated bacteria that provide targeted inhibition of pathogens through the production of antimicrobial peptides.

In April, the X-omics initiative was granted 17 million euros from the Dutch Organization for Scientific Research. The subsidy is part of the National Roadmap for large-scale scientific infrastructure, intended to build or renew large-scale research facilities. What new insights will this investment…

Early treatment benefits patients who have not fully developed rheumatoid arthritis but are in the preliminary stages of the disease. This is what researchers from the Leiden University Medical Centre (LUMC) have reported in The Lancet. Patients in the pre-arthritis stage who were temporarily prescribed…

Professors Simcha Jong (Leiden University) and Rifat Atun (Harvard University) convened an exploratory seminar to discuss challenges for health systems in realising the potential of precision medicine at Harvard University’s Radcliffe Institute for Advanced Studies in Cambridge, MA on 17 April 2017.

Together with patient representatives, clinician-researchers from Radboucumc (Internal Medicine) Amsterdam UMC and researchers from Leiden University (Andrea Evers and Henriët van Middendorp) have received the Medical Inspirator Prize 2019 of The Netherlands Organisation for Health Research and Development…

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

These syntheses allow the team to determine the extent to which schools-based interventions are effective at targeting radicalisation-related outcomes.

Studying the impact of urbanisation on the respiratory health of past Dutch populations (1200-1850 CE).

Living systems scale from unicellular microbes to complex multispecies communities that constantly change over time. Within the theme Development & Disease, we enhance our fundamental understanding of development and homeostasis of living cells and systems. We analyze the normal situation and how stresses…

Leiden University neuropsychologists have shown that customised intervention pays off. A new fundamental research-based approach in children who are in danger of going off the rails has delivered spectacular results.

Soil is a home for an unbelievable diversity and abundance of microbial life that is essential for supporting life on our planet.

Bone research provides plenty of detailed data about the health of a person or a group. This data is not only used to reconstruct the past but also to fight disease today.

The emergence of complex diseases resulting from abnormal cell-cell signaling and the spread of infectious diseases caused by pathogens are significant threats to humanity. Unraveling the dynamic mechanisms underlying cell-cell signaling and infectious disease spreading is crucial for effective disease…

Street theatre, drama, poetry and a lot of science: Leiden's Rapenburg was the backdrop for the fifth Night of Art and Knowledge on Saturday 16 September. Many University buildings - from the Observatory to the Hortus - opened their doors to artists, scientists and a public curious to know more.

Having a chronic somatic condition can result in a variety of impairments in patients’ daily lives, including not only physical complaints such as pain, itch, and fatigue, but also problems of negative mood and impairments in social relationships. Next to disease characteristics, individual difference…

LUMC researchers are looking for factors that point to illness at an early stage.

LUMC researchers are looking for factors that point to illness at an early stage.

Gaucher disease is a rare metabolic disorder, in which a mutation of the enzyme glucocerebrosidase (GBA1) causes buildup of its substrate glucosylceramide and the deacylated counterpart glucosylsphingosine in lysosomes.

With this thesis the PhD-candidate aims to enrich the body of evidence concerning the relation between stress and health, and the mediating role of (un)conscious perseverative cognitions, which is captured in the extended perseverative cognition hypothesis.

Heart patients who maintain a healthy lifestyle can start earning discounts at shops or for trips out. The Tergooi Hospital is the first in the Netherlands to introduce this unique method that was co-developed by the research group headed by Professor of Health Psychology Andrea Evers and the Leiden…

This minor is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs. Students learn how disease and drug-induced alterations in signaling pathways can be used for the discovery of new drug targets and the development of personalized drugs.

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

Migraine is a brain disease. If it were simple, we would have solved it already'. That is the title of the inaugural lecture delivered by Professor of Neurology Gisela Terwindt on Friday 3 June. In her speech she emphasises the importance of research into the differences between women and men with m…

This minor focuses on the relationships between behaviour, health and illness.

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

The Violence and Violence Prevention research group investigates the complexity of contemporary violence, its various manifestations, and strategies for prevention.

Mirjam van Reisen favours big data built up from local inputs in developing countries and suitable for local use. The new Professor of Computing for Society at Leiden's Faculty of Science connects data science with development sociology. Inaugural lecture 10 March.

Health psychologist Andrea Evers has won the Stevin Prize – alongside the Spinoza Prize, the highest scientific award in the Netherlands. Evers: 'It’s also a prize for our whole team and our many contacts within and outside the University.’

Our mission is to improve the description, prediction, understanding and the prevention and treatment of mood disorders, including unipolar and bipolar depression, as well as suicidal thoughts, feelings, and behaviors. To tackle this ambitious mission, we focus on several research streams.

Multiple Sclerosis, Parkinson’s and Alzheimer’s disease are the most common neurodegenerative disorders. Unfortunately, no effective treatments are currently available to halt the progression of these neuroinflammatory diseases [1].

We are confronted on a daily basis with news about the Corona virus and its consequences. We read alarming headlines like 'Dutch becoming increasingly anxious about Corona virus' or 'Huge fears and stress about Corona crisis'.

In cities, parks take the blame for mosquito problems. However, the real issue is usually a few streets away. Drains and standing rainwater create ideal breeding grounds for larvae. As a result, controlling adult mosquitoes in parks makes little sense, says environmental scientist Louie Krol in his…

How can we develop new chemical biology tools and approaches to understand and interfere with glucosylceramide metabolism in relation to Gaucher disease?

It is becoming increasingly clear that the placebo effect has a great influence on medical treatment. An international, interdisciplinary team of researchers led by Professor of Health Psychology Andrea Evers from Leiden University has now written a first set of guidelines on how to apply the placebo…

Promoting sustained physical activity through tailored incentive-based interventions for diverse cardiovascular disease patient groups.

Promotor: J. Kuiper

A continuous learning pathway in suicide prevention equips psychology students with essential knowledge and skills to recognise suicidality effectively and to initiate the conversation about it.

An important hormone excreting gland in the human body is the pituitary

Health psychologist Aleksandrina Skvortsova has made clever use of the Pavlov effect to link the ‘cuddle’ hormone oxytocin with the placebo effect. This effect can alter the level of oxytocin in the body, making it possible for people to reduce the amount of medicine they need while still feeling good.…

Focus in skin research

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.

In the Netherlands, 1.55 million people suffer from cardiovascular diseases. Yet, acute cardiovascular events, such as a heart attack or stroke, often occur unexpectedly. That is because many people do not know they are at risk for such an event. Immunological researcher Amanda Foks and her colleagues…

Alzheimer's disease (AD) is the most frequent neurodegenerative disorder and the primary cause of dementia. The neuropathological features of AD include the occurrence of senile plaques, neurofibrillary tangles, decreased synaptic density, and loss of neurons. An obstacle in the study and treatment…

Promotor: Prof.dr. J. Kuiper

On 11 November Professor of Gastroenterology and Hepatology, Monique van Leerdam will deliver her inaugural lecture entitled, ‘Aiming for Prevention’. Van Leerdam, who specialises in hereditary tumours, was appointed professor in July 2020. In her inaugural lecture she will discuss the importance of…

The Violence and Violence Prevention research group at Leiden University focuses on understanding and preventing violence in modern societies. The group offers two key educational programmes: the Minor Violence Studies and the Governance of Violence specialisation within the Master’s in Crisis and Security…