What are the principles of genome folding and dynamics in bacteria?

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.

Extending our current arsenal of antibiotics is key to staying ahead in the arms race between humans and resistant bacteria.

How do lipases in Mycobacterium tuberculosis help the bacteria survive, and can we target them to create new antibiotics?

Parasitic worms and stomach bacteria suppress immune reactions such as allergic responses. Parasitologist Hermelijn Smits and lung specialist Christian Taube from the LUMC are trying to learn from these micro-organisms.

Global healthcare is on the verge of an antibiotic availability crisis as bacteria have evolved resistance to nearly all known antibacterials. Identifying new antibiotics that operate via novel modes-of-action is therefore of high priority.

In an unpredictable environment bacteria evolve the same strategy as shareholders who try to protect themselves against unpredictable swings in the stock market. Experimental evolution biologist Dr Bertus Beaumont published an article on this discovery on 5 November in the journal Nature.

Bacteria use antibiotics as a weapon and even produce more antibiotics if there are competing strains nearby. This is a fundamental insight that can help find new antibiotics. Leiden scientists Daniel Rozen and Gilles van Wezel published their research results in the authoritative Proceedings of the…

How do bacteria sense and adapt to their environment? Ariane Briegel, Professor of Ultrastructural Biology, is intrigued by this question. Using new techniques, she produces three-dimensional images of bacteria that provide us with new clues about their sensory system.

Ariane Briegel wants to use bacteria to detect cancer at an early stage. Together with postdoc Alise Muok, she is developing a method to quickly and cheaply test the urine of patients for the presence of suspicious molecules. They receive a grant of approximately 150,000 euros from the Dutch Cancer…

Soil bacteria can produce a wealth of antibiotics that are new to us, claims Gilles van Wezel, Professor of Molecular Biotechnology at the Institute of Biology Leiden. His research group has developed a method that can rapidly identify and produce these unknown compounds.

Imagine that you need to travel, but you don’t have a car and you’re dead broke. What do you do? Hitchhiking, of course! Leiden biologists found that certain bacteria use this very same tactic: their spores hop on motile bacteria and use them as a taxi, ensuring they reach the right environment to f…

Freezing bacteria super fast to gain a true-to-nature image of the internal and external structure. Ariane Briegel Professor of Ultrastructural Biology came to Leiden specially to carry out this research. Leiden University is one of the few institutes in the world to have the necessary equipment. Inaugural…

With the rise of multi-drug resistant bacterial pathogens, the possibility of a post-antibiotic world is quickly becoming reality.

This ecological community has long been known to affect host biology, and their diverse roles have been further clarified in recent years following numerous studies of animal:microbiota interactions in diverse systems.

What is the relation between the experience and the act of exclusion?

Bacteria found in soil specialise in the colony by division of labour. Some of the bacteria produce antibiotics, even when it comes at the expense of their individual reproduction success, to defend their colony against competitors. Publication in Science Advances.

Streptomyces are prolific producers of enzymes and secondary metabolites, including more than 50% of all clinical antibiotics. This makes them highly attractive for medical, biotechnological, and industrial purposes.

On 1 August, Lars Jeuken started work as Professor of Biophysical Chemistry at the Leiden Institute of Chemistry (LIC). His research is at the intersection of biology and chemistry, but also involves physics and nanotechnology. Jeuken: ‘By linking nanoparticles to proteins and bacteria, we want to convert…

Gubbens

Specific fatty acid-sugar molecules allow leprosy bacteria, among others, to hide from our immune system. How exactly is not entirely clear. Hessel van Dijk, who received his PhD on 13 October, replicated the molecules, helping to solve a piece of the puzzle. Van Dijk's dissertation is titled: Synthesis…

Plants love favourable microbes such as bacteria and fungi: they grow better and become healthier. Jos Raaijmakers, Professor of Microbial Ecology, is in search of the right microbes to be used in agriculture. Inaugural lecture 13 November.

The consequences of social tendencies for the legislation and institutions in the fields of social security, the labor market policy and pension reform are examined in this multdisciplinary research program..

The overall objectives of my thesis are to investigate the dynamics of the sorghum root microbiome and to explore the beneficial effects of the root microbiome on sorghum growth and stress tolerance.

The investigation into the bidirectional communication between the gut and its host is a rapidly growing area of research, attracting considerable attention for its potential to provide crucial insights into health and disease.

Macrophages – the front line of our immune system – protect us from infections. But in the case of the tuberculosis bacteria, this often goes wrong. The group of Annemarie Meijer from the Leiden Institute of Biology has now discovered that macrophages in zebrafish are better able to eliminate tuberculosis…

Though tuberculosis can be cured today, new resistant strains of the bacteria are becoming a growing problem in the medical world. Biologist Annemarie Meijer and her colleagues are studying resistance to this disease. Their research is already yielding several interesting clues that could help the development…

Like ants, termites and bees, some bacteria work together as a multicellular group. There is a strict division of labour in such colonies, to make the group more resilient to the outside world. Now researchers have found that some parts of the bacterial colony can take ‘for the greater good’ to a whole…

Why does social anxiety increase in adolescence and how does it grow out of control in some adolescents?

Biological chemist Nathaniel Martin is going to test an alternative antibiotic that can combat common resistant bacteria such as MRSA. For this purpose, he will receive 350,000 euros from the NWO's NACTAR programme. ‘We want to know how safe and effective our antibiotic is in a realistic situation.’

More than 1.3 million people worldwide die of tuberculosis (TB) each year, making research on its prevention and control essential. Researchers from various disciplines in Leiden are studying TB. A symposium on 24 March will highlight different activities in the hope of boosting nationwide collabora…

This project aims at studying the social media reception of African publications as covered by the most important “altmetric” sources.

This thesis, conducted in the framework of ERC Starting grant project BABYLON (PI: Caroline Waerzeggers), presents an investigation into Babylonian society, focusing on the city of Borsippa during Neo-Babylonian and early Persian rule (c. 620-484 BCE).

This dissertation takes an important step in understanding the phenomenon of non-take-up of social support and what it means for contemporary social policies.

The aim of this thesis is to study cell-cell interactions and the development of an assay to explore and quantify the exchange of membrane compounds.

Why do some children confront social challenges with confidence, whereas others experience difficulties? What is the role of child temperament and child emotional dispositions? What is the role of parenting? This project aims to shed light on the mechanisms explaining shyness and confidence in response…

Are there any differences in gaze behavior between high and low socially anxious individuals? What factors influence the relation between social anxiety and gaze behavior?

A neurobiological perspective on individual differences in social competence

The studies outlined in this volume explore how connectedness continues to change Africa and how Africa continues to shape the social life of connections.

Do you have to be able to say everything on Twitter and Facebook? Is Instagram morally obliged to remove photos from attacks? Should we allow the terrorist group to recruit new members on the internet?

At the Young Academy Leiden, we care deeply about fostering social safety at our university. Increasing social safety is of particular importance to early career scholars as they often find themselves in a vulnerable position without a permanent contract, or with a dependence on superiors for progressing…

Helping people, groups and policymakers navigate the social transitions of our time.

The intestinal bacterium E. coli can adapt to changes in its surroundings. Leiden scientists have discovered how the H-NS protein makes this possible. This new knowledge can be an important starting point in combatting bacteria and diseases such as peritonitis. Publication 2 October in the journal e…

At FGGA, we want our staff to feel safe in all respects. We therefore strive to create a work environment where we treat each other with respect, where we promote inclusion and where we speak up if we experience or witness unsafety.

Pieter de la Court, Wassenaarseweg 52, 2333 AK, Leiden

Social Science Matters is an online variant on London’s famous Speakers’ Corner – a platform for the researchers in the various disciplines in the Faculty of Social and Behavioural Sciences to react to the news. This soapbox gives our social scientists an opportunity to voice their opinions on current…

Efficiently responding to others’ emotions has great survival value, especially for social species, such as primates, who establish close, long-term bonds with group members. The closest living relatives to humans are the chimpanzee and the bonobo. Studying these species, and comparing them on the exact…