Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

PhD defence

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

How do macrophages and neutrophils contribute to metastatic onset?

What are the biological and biophysical mechanisms that control chemokine gradient sensing and migration of immune, endothelial, and tumour cells in tumour development?

This dissertation combines the use of defined microenvironments, high-resolution fluorescence microscopy, and time-resolved analysis, to study intracellular and cellular motility.

Promotor: T. Schmidt, Co-Promotor: B.E. Snaar-Jagalska

This thesis tackles the difficulty of predicting the liver’s clinical response to novel therapies, a challenge arising from interspecies differences and limitations of existing in vitro models.

PhD defence

The Hazelhoff Centre for Financial Law team regularly publishes in both Dutch and international academic journals and book series.

Susanna Lindberg(ed.), Artemy Magun (ed.), Marita Tatari (ed.) With this book, we would like to resume the passionate conversation that Jean-Luc Nancy was engaged in throughout his life, with philosophers and artists from all over the world. Now that he has passed away, it is not enough for us to…

Bispecific antibodies with one Fab arm binding to effector cells, such as T-cells and NK-cells, while the other Fab arm recognizing a tumor associated antigen (TAA) can be used to redirect these effector cells for tumor specific killing. Using bispecific antibodies to treat hematological cancers is…

Prostate cancer (PCa) is one of the most prevalent cancer in males.

Promotor: J.A. Bouwstra Co-promotor: A. El Ghalbzouri

Enabling volume-restricted metabolomics using next-generation microscale analytical tools.

Microbial rhodopsins are photosensitive pigments implemented in the growth and adaptation of a large population of microorganisms.

G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.

In this research project, we aimed to obtain more insight in the role of mast cells in the immune driven disorders rheumatoid arthritis and atherosclerosis.

Can Cyanobacteria be engineered to convert the greenhouse gas carbon dioxide into the valuable chemical isoprene?

PhD defence

PhD defence

Indigenous Pasts and the Roman Present

Plants, algae and cyanobacteria have the amazing capacity to perform delicate photophysical and photochemical processes of light capture, excitation transfer, charge separation and catalysis in fluctuating living environments. As a consequence, photosynthetic proteins and membranes form dynamic architectures.…

Below you will find a collection of books, other than those in the BLRN book series, to which members of BLRN have contributed.

PhD defence

Can we bring novel treatment options to the clinic for UM patients with liver metastases?

The group of Dr. Roxanne Kieltyka designs and synthesizes molecules that self-assemble into polymeric materials using specific non-covalent interactions. These substrates can be used for numerous applications in medicine ranging from disease detection to cell delivery depending on the (bio)molecular…

The Immune Activation and Tolerance group is headed by Dr. Bram Slütter. Vaccination is an experimental, but promising, treatment strategy for atherosclerosis. Previous work has shown that immunization of mice with modified LDL particles can reduce atherosclerotic lesion development, however such vaccines…

Op zaterdag 27 februari organiseert Stichting Zenobia het Vijftiende Zenobiacongres, met de titel Van de Levant tot de Lagune: Venetië en het Oosten. Het congres zal online plaatsvinden en is vrij toegankelijk.

Het project heeft plaats gevonden in de KM3NeT Nikhef Amsterdam groep onder begeleiding van Dr. D.F.E. Samtleben en Prof.dr.ir. T.H. Oosterkamp. De titel van de presentatie is:

Het project heeft plaats gevonden in de Gorter LUMC groep onder begeleiding van Dr. J.W.M. Beenakker en prof.dr.ir. T.H. Oosterkamp . De titel van de presentatie is:

Op vrijdag 4 april 2025 organiseert de werkgroep Stedengeschiedenis een bijeenkomst bij de Rijksdienst voor het Cultureel Erfgoed onder de titel ‘Archeologie en de stad’. De studiedag is gratis en voor iedereen toegankelijk.

Het project heeft plaats gevonden onder begeleiding van Prof.dr.ir.Tjerk Oosterkamp. De titel van de presentatie is:

Het project heeft plaats gevonden in de QMO groep onder begeleiding van Dr. Michiel de Dood en Dr.ir. Sense Jan van der Molen. De titel van de presentatie is:

Tussen 14 en 30 september 2022 wordt Het Land van Belofte gespeeld door Theatergroep De Kale. Het Land van Belofte neemt u mee naar de groteske verhaalwereld van middeleeuwse pelgrims naar het Heilig Land. Het Land van Belofte is gebaseerd op het zestiende-eeuwse tafelspel Schipper, Pelgrim en Post.…

Op donderdag 17 april 2025 neemt prof. dr. Marco Mostert, Hoogleraar Middeleeuwse Geschiedenis aan de Universiteit Utrecht afscheid.

How have human-environmental entanglements changed in the Gulf of San Miguel, Darien, Panama, from the first traces human practices through to the present?

Exploiting metabolic vulnerabilities to identify anticancer compounds in zebrafish synthetic lethality screens.

The last two months of 2016 were a very productive time for the ACPA. We had no less than 6 promotions!

Within the ICM 2018 project, Leiden University cooperated with 25 partner universities from 14 countries. In total, 97 mobilities were granted to this project - 65 mobilities were realised (some mobilities had to be ended prematurely due to covid-19, others were finished online).

On Monday the 8th of December, the annual symposium of the IBL will be organized at the main building of the LUMC Leiden. This year’s theme is “Integrative Biology towards Healthy Communities”.

The Oncode Institute is a new international network organisation that focuses on making sure that new scientific findings on cancer are implemented in patients as rapidly as possible. Two young female researchers at Leiden University have been selected to join Oncode: Laura Heiman (Leiden Academic…

Zebrafish-human communication shows that cancer cells lacking a signaling protein are less able to develop aggressive metastatic properties. This discovery has been made by molecular cell biologist Claudia Tulotta. PhD defence 14 June.

As of April 1, 2018, Erik Danen has been appointed as Professor of Cancer drug target discovery at the Leiden Academic Centre for Drug Research (LACDR). His discipline is cell biology of cancer, in which he focuses on the mechanisms underlying metastasis and therapy resistance.

Ewa Snaar-Jagalska, Shuning He and colleagues from IBL, LION and LACDR reported on a new zebrafish study to understand micrometastasis of human cancer cells. They discovered a novel role for neutrophils in assisting metastasis formation, which provides critical insights for anti-cancer therapies.

Met groot plezier heeft de Universiteit Leiden van 1 tot 4 november het X Congreso Internacional de la Asociación de Hispanistas del Benelux (AHBx) georganiseerd, met het thema Transhispanismos: contactos y contagios (Transhispanismes: contact en besmetting). De AHBx is een platform in de Benelux dat…

As of 1 November, Laura Heitman has been appointed full Professor of Molecular Pharmacology at the Leiden Academic Centre for Drug Research (LACDR). Heitman has been working on the understanding and improvement of drug-receptor interactions in early drug discovery. ‘My ultimate aim is to make medicines…

PhD defence

PhD defence

Upcoming activities by docARTES PhD candidates Shaya Feldman, Anne Veinberg, Ned McGowan and Nizar Rohana, PhDArts candidates Brigitte Kovacs, Eleni Kamma, Danne Ojeda, Andrea Stultiens and K.G.Guttman and ACPA PhD candidate Henri Bok.