What happens if a Member State decides to withdraw from the European Union? The “Brexit Charts” aim to provide information on the withdrawal procedure under Art. 50 TEU, on the legal consequences of leaving the EU and on the future relationship of the withdrawing state with the European Union.

Are you a British citizen currently studying or working at Leiden University? Or are you a Leiden University student (thinking of) studying abroad in the UK? Find out about the effects of Brexit.

Joris Larik, Assistant Professor at Leiden University, wrote about the topics of the Brexit, the EU-UK Withdrawal Agreement, and Global Treaty (Re-)Negotiations.

Ending the United Kingdom’s (UK) forty-seven year European Union (EU) membership has fundamentally transformed its relationship with the EU. After years of tumultuous negotiations, international law now once again governs the UK’s relationship with the EU. This has resulted in a sophisticated body of…

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

This study investigates how two social and political developments, in the UK and Germany, impacted on the experiences of minorities and the attitudes of majorities vis-à-vis tolerance in those two countries. The results provide a thought-provoking picture of the views of minority and majority groups…

In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

How can zebrafish research help to understand and fight human cancer?

Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm

Some people are predisposed to develop cancer. Mutations in genetic material that increase a person’s chances of developing cancer can already be present at birth. Researchers are closely examining these mutations to learn more about how cancer begins to develop.

With cancer, a person’s body cells grow uncontrollably. Putting together a detailed picture of how this comes about makes it possible to develop efficient therapies. Researchers at the Leiden University Medical Centre (LUMC) and Leiden University are working together to gain a better understanding…

Cancer represents a formidable current and future global health challenge. The LUMC medical research profile Cancer Pathogenesis and Therapy charges this challenge by developing and implementing innovative patient-tailored, multimodal diagnostic methods and treatment modalities.

We focus on a better understanding of the mechanisms of cancer drug resistance and metastasis.

In this research group, headed by Prof. Erik Danen, the aim is to unravel cellular signaling mechanisms in normal and diseased cells, with a long-standing interest in cell adhesion signaling. In complex multicellular organisms such as ourselves, a division of labor emerges where different tissues and…

The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.

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Promotor: Prof.dr. B. van de Water, Co-promotor: E.H.J. Danen

In this research group, headed by Bob Van de Water, cell signaling programs that underlie adverse drug reactions as well as cancer development and progression are unraveled. Adverse drug reactions involve cell injury in critical target organ cells which leads to the activation of cellular stress response…

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

Mechanisms fro drug resistance

Breast cancer is the most common cancer in women worldwide. Metastasis, the process by which cancer cells spread to other parts of the body, makes treatments less effective. It is important to unravel the mechanism of metastasis.

To improve treatment of breast cancer patients it is important to understand all stages of breast cancer from initiation to in situ disease and progression to invasive disease. In this thesis we use intraductal injections of patient derived tissue to model ductal carcinoma in situ and invasive breast…

Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.

What distinguishes a tumour cell from a healthy cell? Researchers are trying to answer this question as precisely as possible. Certain differences could eventually lead to new therapies.

Promotores: J. Jonkers, K.E. de Visser

Can the conditioning paradigm be used for checkpoint inhibition cancer treatment?

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

The Maastricht Journal of European and Comparative Law has published an article by Christa Tobler, entitled ‚One of Many Challenges After ‚Brexit’. The Institutional Framework of an Alternative Agreement – Lessons from Switzerland and Elsewhere?’ (Maastricht Journal of European and Comparative Law 23…

The 9th Network Europe Conference in Edinburgh was held at June 2017 in Edinburgh and organized by the Europa Institut Zurich. The contributions of the conference are now published.

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

On 5 December, Armin Cuyvers gave a lecture on the legal complications surrounding Brexit for Clingendael, the Netherlands Institute for International Relations.

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

Rector Magnificus Carel Stolker will retire on 8 February. If there’s one theme running through his career, it’s the links between the University and society. In this series of pre-retirement discussions, Stolker will talk one last time to people from within and without the University. This time he…

Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

Cancer is the leading cause of death in the Netherlands, and, with over 100 different types of cancer, it’s not a simple disease. Today, skin, breast, lung, prostate and colon cancer are the most diagnosed forms. Therefore, the discovery and development of new drugs has the ability to significantly…

Promotores: Wim Jiskoot; Ferry Ossendorp

Exploiting metabolic vulnerabilities to identify anticancer compounds in zebrafish synthetic lethality screens.

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

In the hunt for a vaccine against cervical cancer, fundamental knowledge about the immune system and organic chemistry have been brought together and have already resulted in a vaccine that is now being tested in clinical trials. Scientists are now working hard on an improved variant.

In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…

How to identify patients at risk of developing devastating, metastatic disease and facilitate the development of personalised treatment for prostate cancer patients?

On 8 November 2017, The Law Societies Joint Brussels Office of the UK organised a seminar on the subject of ‘Brexit: Where & How to Enforce: Building Blocks for a New Dispute Settlement System’. The seminar was held in the building of the European Parliament in Brussels.

In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

On 18 October, Armin Cuyvers, Associate Professor of European Law at the Europa Instituut, spoke at the Law School of Sydney University on reconciling political drama and legal realities in Brexit.

Armin Cuyvers was interviewed for the weekly science page of local newspaper Leidsch Dagblad, about Brexit and its legal complications in relation to Norther Ireland.

In the last few weeks Armin Cuyvers was several times in the news on Brexit. He was a studio guest during the new years episode of Legal Affairs on BNR national radio and he was a studio guest in the news programme EenVandaag.

On 11 November, Armin Cuyvers, Assistant Professor at the Europa Institute in Leiden, was one of the speakers on Brexit during the autumn meeting of the Netherlands Association for European Law (NVER).

The Common Market Law Review is proud to present a Special Issue on legal issues relating to Brexit following the lustrum conference on Brexit and the Future of the European Union that was held in Leiden in 2017 to mark the 60th Anniversary of the Europa Institute of Leiden University.

The August issue of the CML Rev., Vol. 53 No. 4, is now available online.