Source: International Journal of Cosmetic Science, Volume 37, Number 1, pp. 148-148 (2015) ISBN: 0142-5463

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The barrier function of the skin is primarily provided by the stratum corneum (SC), the outermost layer of the skin. Skin barrier impairment is thought to be a primary factor in the pathogenesis of atopic eczema (AE).

Atopic eczema is a skin disease with increasing incidence currently affecting 25% of the paediatric population. In atopic eczema the skin barrier function is reduced. This barrier is formed by the outermost layer of the skin called the stratum corneum (SC). The SC consists of terminally differentiated…

OBJECTIVES: To determine whether the lipid/protein ratio and the total dry SC mass per surface area are related with the skin barrier function of controls and AE patients.

Pharmacologist Walter Boiten developed a new method to determine the amount of lipids in a person's skin. With this method he tested the effects of a new cream he developed for eczema patients. The first results are promising. Boiten defends his dissertation on 15 January.

An important feature of atopic eczema (AE) is a decreased skin barrier function. The stratum corneum (SC) lipids - comprised of ceramides (CERs), free fatty acids (FFAs) and cholesterol - fulfill a predominant role in the skin barrier function.

Are you in the final stage of your bachelor or master program? And do you want to research a topic that has to do with sustainability? Then, this document is the right one for you. In this document, several sustainability related topics from a variety of studies is coming together which can give you…

Source: Journal of Investigative Dermatology, Volume 135, pp. S59-S59 (2015)

In our research and education, we focus on the following topics:

The research connected to this topic is related to Work and health.

Our everyday life consists of all sorts of spatial processes: we find our way to work, remember where we left our keys, and are able to pick up our cup of coffee. We study how the human brain processes such spatial processes. From a clinical perspective, we are interested in how acquired brain damage…

The research connected to this topic is related to E-health.

Music can affect how we feel, think, and behave. But how do we learn about the specifics of people's responses to music so that we can apply this to health and well-being? By looking at characteristics of the music, as well as the differences between listeners, we hope to better understand as well as…

One of the most crucial aspects of our behaviour is our motivation to explore novel environments and interact with new people. This became painfully clear during the COVID-19 lockdowns, when many people suffered from lack of new experiences and real-life social interactions. The relevance of novelty…

The effects of many treatments are determined, to a significant degree, by factors other than the medicine or treatment itself. For example, placebo effects can be equal to the effect size of for example antidepressants or painkillers. Contributing factors are the trust placed in the doctor, the expectation…

Persistent somatic symptoms are long term symptoms that lack a clear medical explanation. These symptoms have a high prevalence where most people know someone who experiences such symptoms or they experience such symptoms themselves. Symptoms can vary greatly in and between people. While one person…

This research line is part of the living lab of the University’s Population Health interdisciplinary program, located at the LUMC Campus The Hague, where the Leiden University Medical Center collaborates with the Faculty of Governance and Global Affairs and the Faculty of Social and Behavioral Sciences…

Our ability to learn and control movements is essential for engaging in goal-directed behaviour. From buttoning your shirt and driving a car, to cooking dinner and brushing your teeth -- our actions in daily life rely on this ability.

Cognitive decline (amongst other problems with attention, concentration, memory) is a common symptom in patients with a variety of brain disorders and has been related to healthy ageing as well. People suffering from cognitive deficits are often significantly hampered in their day-to-day functioning…

The precise psychobiological mechanisms leading to chronic physiological stress responses have not been sufficiently explained, although stress is a major risk factor for disease and early death. A problem for conventional stress theory is that most of these responses seem to occur in situations without…

In case of serious illness, treatment in the Intensive Care Unit (IC) may be necessary. Intensive care treatments has improved over the years and more and more seriously ill patients are surviving admission to the ICU. This favorable development however has a downside since long-term consequences of…

In this research line, the role pharmacological agents and neurochemcial processes play in behavior and cognition is examined with a particular focus on pain, placebo and nocebo effects and intensive care treatments.

Since itch and pain can be very burdensome, especially when individuals suffer from (either of) these symptoms chronically, it is important to know the factors by which these sensations are influenced. It becomes more and more clear that psychological factors play an important role in the experience…

Having a chronic somatic condition can result in a variety of impairments in patients’ daily lives, including not only physical complaints such as pain, itch, and fatigue, but also problems of negative mood and impairments in social relationships. Next to disease characteristics, individual difference…

Promotor: A.W. van der Vaart

We are all aware of the importance of a healthy lifestyle. However, at the same time we also experience many difficulties when we are trying to change our behavior to become more healthy. For example, more often than not our good intentions to exercise more or to eat fewer unhealthy snacks fail miserably…

Imagine that you have a chronic skin condition, characterized by red patches of itchy, scaly skin. You regularly notice people staring at your skin and sense their reluctance to shake your hand. Or imagine that you have Parkinson's Disease, causing your hands to tremble and making it difficult for you…

We study how communication can heal and harm when patients are confronted with an illness. Most of our studies focus on serious illnesses such as advanced cancer. Communication lies at the heart of medicine, yet we do not always know which specific communication helps patients. Moreover, many complaints…

How are the epidermal lipid pathways involved in health and disease.

On the 12th of May, Rita Barrera Virhuez-Eloranta successfully defended a doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Rita Barrera Virhuez-Eloranta on this achievement.

Igor Boog, lecturer of Cultural Anthropology and Development Sociology, received the Casimir Award for most inspiring lecturer of the Faculty of Social and Behavioural Sciences. The jury praised Boog's enthusiasm and his innovative vision on education.

AstroEDU is one of the world's most inspiring education innovations, according to the experts at HundrED. It is a recognition for a place where educators can discover, review, change, and share astronomy- and space-related activities for primary and secondary education, and where they can have their…

Promotor: J. A. Bouwstra

To an algebraic curve C over the complex numbers one can associate a non-negative integer g, the genus, as a measure of its complexity.

This thesis is is made of three parts. The first part describes a generalization of the Chabauty's method, that can be used to determine the rational points of a curve such that s+g>r+1, where g is the genusof the curve, r is the rank of the Mordell-Weil group of the jacobian of the curve and s is…

Promotores: P. Stevenhagen, L. van Geemen (Università degli studi di Milano), Co-Supervisor: Ronald M. van Luijk

Promotor: Prof.dr. A. Achucarro

Are you writing your thesis this semester? Choose a sustainable topic! To help you get started, Leiden University Green Office has made a guideline to write your thesis about a sustainable topic. Find examples, a step-by-step plan to follow and our reasoning behind this project! Or, did you recently…

A memorable farewell symposium and a royal distinction: Professor Joke Bouwstra could not have completed her career at Leiden with more pleasure. On Friday, 14 June, she received a Royal Honor from Leiden Mayor Peter van der Velden, who appointed Bouwstra as a Knight in the Order of the Dutch Lion for…

The key questions posed in this dissertation centre on the interaction between spectator and artwork. What happens between a spectator and an artwork? How do we experience ‘meaning’ in an artwork? How may the process of interpretation be understood and articulated?

Lecture

This year the King’s Speech, read out loud by King Willem-Alexander, was analyzed live again at Leiden University. Scientists, students, and even a hat designer came to discuss the ceremony after the speech.

The Leiden Inclusion Blog is a forum to share experiences and discuss current issues related to diversity and inclusion at Leiden University. Members of Leiden University are welcome to share news, activities, and stories with the wider University community. Everyone can to contribute a blog, or suggest…

On 10 June 2022, a conference on topical issues in Dutch subsidy law was held at the Old Observatory building of Leiden University. With almost 90 enthusiastic participants, it was a huge success!

The Platform for Postcolonial Readings brings together researchers, especially junior researchers, in Belgium and the Netherlands interested in issues of globalization, inter/transculturality, diversity and inclusivity, intersectionality, and postcoloniality. We are an open group (do join us!) and meet…

The organisation of the Platform for Postcolonial Readings is a collaboration of main organisers and occasional guest organisers.

Methodology & Statistics offers bachelor's courses and a master's specialisation.

Didactics