Primary Objective: The primary aim of the proposed RCT is to evaluate whether LF-TLP in blended form as an indicated prevention for anxiety complaints is more (cost-) effective than TAU according to the NHG guideline Anxiety. We hypothesize that in comparison to TAU, LF-TLP will result in a significantly…

When and how does social anxiety develop? How can it go astray in some adolescents? How can we help troubled young people to attend school regularly and return to a normal developmental pathway?

Is blended care a feasible and effective treatment method for social anxiety in adolescence?

What are the circadian disturbances underlying depression vulnerability? How are they related to mood, cognition and sleep ?

Why does social anxiety increase in adolescence and how does it grow out of control in some adolescents?

Optimization, mechanisms of action and predictors of the outcome of light therapy in depression: A multicenter randomized trial

How effective is eye movement desensitization and reprocessing therapy in targeting epilepsy-related anxiety?

Together with researchers from over the world, the ENIGMA-Anxiety Working Group endeavors to unravel the neurobiology of anxiety disorders and related constructs.

Social anxiety disorder is one of the most common disorders in children and young people. Social anxiety is characterized by excessive fear and avoidance of social situations. The primary fear in children with social anxiety is that they will be negatively judged by others. To date, the most frequently…

Welcome to the Social Anxiety and Specific Phobia (SASP) Research Group!

Our mission is to recognise and treat stress and anxiety in children as early as possible, by connecting scientific research, clinical practice and education.

Our mission is to improve the description, prediction, understanding and the prevention and treatment of mood disorders, including unipolar and bipolar depression, as well as suicidal thoughts, feelings, and behaviors. To tackle this ambitious mission, we focus on several research streams.

Parents may pass anxiety onto their offspring by exposing them to anxious behaviors in novel situations. Just as the parents’ anxious signals lead to anxiety, parents’ confident signals can ward off anxiety in the offspring. This project is seeking a new way to break anxiety transmission in the family…

The Leiden Index of Depression Sensitivity (LEIDS) measures cognitive reactivity (CR) to sadness, an aspect of cognitive vulnerability to depression, conceptually similar to rumination.

Serious forms of anxiety concerning other people’s opinions can hinder teenagers at school in social interactions or carrying out tasks. Psychologist Anne Miers is looking for ways to reduce this so-called ‘social anxiety’.

Social anxiety runs in families, but the neurobiology underlying this genetic vulnerability is until now largely unknown. The unique Leiden Family Lab study on Social Anxiety Disorder (LFLSAD) aims to broaden our knowledge with respect to this genetic susceptibility.

To investigate the effectiveness of an online self-help programme for people with HIV and depressive symptoms.

The key question addressed in this family study is whether the psychophysiological and neurocognitive abnormalities often reported in SAD patients are heritable and can thus be found in family members of SAD patients as well. Determination of heritability of these deficiencies is essential for endophenotyping.…

How can we facilitate the early recognition of stress and anxiety in the classroom and collaborate with schools in providing low-threshold interventions?

From basic science to real-world interventions

Do general practitioners recognize children with or at risk of problematic anxiety and is there a pattern that might help differentiate those with and without anxiety disorders in general practice?

We found that, next to the effectiveness of the intervention, it’s also very likely that the intervention is cost-effective compared to attention only.

How do genetic and environmental factors make us vulnerable to depression?

What is the effectiveness of (booklet or online) self-help programmes for people with somatic stressors and depressive symptoms? What works best for whom? How to improve motivation and adherence?

The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.

What are the developmental pathways to social anxiety (disorder), the causal processes and maintaining factors? How do these factors interact in the development of social anxiety disorder? How can this knowledge be used to design and implement effective preventive intervention programs for youth?

Does the public speaking anxiety that many youngsters experience originates from specific characteristics in their earlier development?

How does stress influence cognitive performance? What is the role of selective attention to threatening information in this effect? Could we prevent stress-induced decline of cognitive performance with pharmacological interventions? Could we use resting state theta/beta ratio as a biomarker for cognitive…

Which adolescents are more at risk of developing social anxiety disorder later in life?

This is an Erasmus+ International Credit Mobility project of the Faculty of Social and Behavoriural Sciences with Macquarie University in Australia.

A step-by-step approach to building confidence in anxiety-prone young children.

Predictors of work functioning in persons with multiple sclerosis

What are the social and neural mechanisms that contribute to fluctuations in self-esteem in healthy adolescents and adolescents with depression?

My ERC Starting Grant, funded with €1.5 million for 5 years as part of the Horizon 2020 research and innovation program, is focused on building the early warning system WARN-D to reliably forecast depression in young adults before it occurs. Why depression, and why prediction?

ADHD & ME aims to explore how enhancing self-esteem can break the relation between ADHD symptoms and comorbid disorders, such as anxiety and depression. In this study we assess the effectiveness of a Cognitive Behavioural Therapy (CBT) program called Competitive Memory Training (COMET) for improving…

Depression has traditionally been linked to increased inflammation. Innovative research by psychologist Eiko Fried refutes this popular assumption. He shows that specific depression symptoms such as sleeping problems explain this relationship. Publication in Psychological Medicine .

The overarching aim of this theme is to increase our understanding of the mechanisms underlying altered cognitive, affective, and social behavior in relation to mental health problems.

Programs that aim to reduce symptoms of social anxiety in children generally include multiple components, such as exposure and cognitive restructuring. It is unknown if separate components yield positive intervention effects in children or whether a combination of components is required.

Some people are more sensitive to depression than others. But why is that the case? Clinical psychologist Niki Antypa studied how vulnerability to depression is influenced by cognition. She also found a first careful indication that a treatment with omega-3 fatty acids might provide a solution.

Is EEG theta\beta ratio predictive towards the negative effects of stress on cognitive performance in individuals suffering from performance anxiety? Can we improve resilience to performance anxiety by using a theta\beta ratio neurofeedback intervention?

I want to understand the overlap between physical health, mental health, and healthy aging and whether/how stress (behaviorally and biologically) may tie these concepts together.

Toward optimal measurement and greater understanding of youth cognition in school refusal and cognitive behavioural therapy outcome

Up to 45% of patients with Parkinson's disease experience impulse control disorders, characterised by a loss of voluntary control over impulses, drives or temptations. This study aimed to investigate whether previously identified genetic and psychiatric risk factors interact towards the development…

Building cultures of legality: lawmaking and anxiety in the office of the Governor General.

What is the role of stress and stress-related hormones in emotion regulation?

Can zebrafish larvae be used as a behavioural model for screening natural products as potential neurotropic drugs?

The aim of our research program is to better understand the etiology and course of mood, anxiety and stress-related disorders, such as depression and posttraumatic stress disorder (PTSD). We investigate both the transdiagnostic mechanisms underlying these disorders and work on improving the treatments…