Persistent somatic symptoms are long term symptoms that lack a clear medical explanation. These symptoms have a high prevalence where most people know someone who experiences such symptoms or they experience such symptoms themselves. Symptoms can vary greatly in and between people. While one person…

To investigate the effectiveness of an online self-help programme for people with HIV and depressive symptoms.

Begin oktober vond de eerste Psychology Connected van dit nieuwe academische jaar weer plaats. Met de vallende herfstbladeren voelen velen zich ook somberder. Onderzoekers delen hoe je een winterdepressie verzacht, en hoe je als ouder het beste kunt omgaan met de depressieve klachten van je kind.

What is the effectiveness of (booklet or online) self-help programmes for people with somatic stressors and depressive symptoms? What works best for whom? How to improve motivation and adherence?

Pharmacometrist Bas Goulooze has won the prestigious Lewis Sheiner Student Session award. He received the prize of 300 euros at the annual conference of the Population Approach Group Europe (PAGE) in Stockholm, where he presented his research for 800 people.

A new therapy for the serious Graft-versus-Host disease

Somatic symptoms, such as pain, itch, and fatigue have been shown to have a bidirectional relationship with mental symptoms. Although acute somatic symptoms serve some adaptive properties, chronic symptoms can instead lead to interference in daily activities and lower quality of life.

Veel vrouwen in een opvanghuis kampen met een posttraumatische stressstoornis (PTSS). Deze PTSS-klachten herkennen en direct behandelen biedt volgens het Leids Universitair Behandel en Expertise Centrum (LUBEC) de meeste kans op succes. Daarom werkt LUBEC per 1 september samen met vrouwenopvangorganisatie…

We found that, next to the effectiveness of the intervention, it’s also very likely that the intervention is cost-effective compared to attention only.

Medical psychologist Willeke Kitselaar developed a model that helps identify patients with persistent somatic symptoms earlier, based on an extensive large medical database. ‘I advise GPs to ask patients to fill in a questionnaire about both physical and mental symptoms at an earlier stage.’ PhD defence…

CERQ is a questionnaire measuring cognitive coping strategies developed by Dr. Nadia Garnefski and Dr. Vivian Kraaij.

In the MS Cognitietour, psychologists and neuroscientists from Leiden University discuss the latest scientific knowledge with MS patients and their loved ones. This leads to insights: 'One lady told how much stress she felt from all those caregivers around her bed.'

People already diagnosed with a mental disorder before the COVID-19 pandemic did not show a disproportionate increase in symptoms afterwards. This is one result from the first systematic review of longitudinal studies following their study population from before to during the first eighteen months of…

Scientists in Leiden are looking for signals in blood samples to predict whether patients will develop serious COVID-19 symptoms or not. Based on that knowledge, they will be able to propose targeted therapies to prevent serious symptoms. They hope to come up with the first results within the week.

PhD defence

Our mission is to improve the description, prediction, understanding and the prevention and treatment of mood disorders, including unipolar and bipolar depression, as well as suicidal thoughts, feelings, and behaviors. To tackle this ambitious mission, we focus on several research streams.

Can positive peer feedback break the cycle of negative self-relevant cognitive processes and reduce self-reported anxiety in early adolescents?

Our vision of stress is starting to change fundamentally. We can suffer stress without even being aware of it, while sleeping as wall as during the day. Professor of Psychology Jos Brosschot will discuss this phenomenon in his inaugural lecture on 2 December.

This longitudinal study is focused on neurodevelopmental problems in young children with XXY, XXX and XYY, aged 1 to 6 years.

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

In a longitudinal study, Eichengreen and colleagues explored how the certain aspects of emotional intelligence impact the development of adolescents’ mental health, thus identifying potential warning signs and targets for intervention programs. Despite a higher risk for mental health issues and lesser…

The key question addressed in this family study is whether the psychophysiological and neurocognitive abnormalities often reported in SAD patients are heritable and can thus be found in family members of SAD patients as well. Determination of heritability of these deficiencies is essential for endophenotyping.…

Optimization, mechanisms of action and predictors of the outcome of light therapy in depression: A multicenter randomized trial

Elk jaar organiseert het LIBC in samenwerking met de gemeente Leiden een Publieksdag over hersenonderzoek.

How do parents communicate anxiety to their child via body language and words? Psychologist Cosima Nimphy studied this question for her PhD research. Experiments show that children of anxious parents are not more sensitive to their parents’ signs of anxiety.

Members of our research team give different types of presentations and lectures.

Imagine getting a notification on your mobile phone with your personal code for impending mental health problems or even depression: yellow, orange, or red. Science fiction? Not for scientist Eiko Fried. 'There is a real chance we can prevent some mental health problems before they occur.' Want to participate…

ADHD & ME aims to explore how enhancing self-esteem can break the relation between ADHD symptoms and comorbid disorders, such as anxiety and depression. In this study we assess the effectiveness of a Cognitive Behavioural Therapy (CBT) program called Competitive Memory Training (COMET) for improving…

Programs that aim to reduce symptoms of social anxiety in children generally include multiple components, such as exposure and cognitive restructuring. It is unknown if separate components yield positive intervention effects in children or whether a combination of components is required.

The ability to collect and interpret huge quantities of data has become indispensable to society and academia. Leiden University is a knowledge and expertise centre for data science that places the emphasis on interdisciplinary collaboration and innovation.

Adolescents with good friendships experience fewer anxiety and depression symptoms, PhD student Iris Koele discovered in her research on high school students' social relationships. 'As a psychologist, I include friends in the treatment plan: who do you call when things are not going well?'

Exploring the synergy of light therapy and exposure psychotherapy to enhance PTSD treatment outcomes.

Disclaimer: Manuscripts related to the Resilience Center are for academic purposes only and are not intended for mass distribution or copying. Please refer to applicable laws for fair use, including copyright holders' restrictions on publications.

We investigate the molecular basis underlying health and disease and provide answers to existing and emerging health problems. Within this theme, we study diseases ranging from rare genetic disorders to cancer and infectious diseases. We make use of a wide variety of model systems and pursue diverse…

Inaugural lecture

The ‘Leer te Durven!’ program (Learn to Dare) is a preventive training program for children with mild anxiety symptoms (Simon & Bögels, 2014). The program has been developed for children between the ages of 8 and 12 who feel or behave anxiously, avoid situations, are afraid of doing things wrong, appear…

Our mission is to recognise and treat stress and anxiety in children as early as possible, by connecting scientific research, clinical practice and education.

Gravitation programme grant Co-applicants Bernet Elzinga en Andrea Evers are two of the captains of the six teams, all led by main applicant Anita Jansen, Maastricht University.

The effects of many treatments are determined, to a significant degree, by factors other than the medicine or treatment itself. For example, placebo effects can be equal to the effect size of for example antidepressants or painkillers. Contributing factors are the trust placed in the doctor, the expectation…

Children and young people who are victims of emotional abuse at the hands of their parents often report the symptoms of severe post-traumatic stress. These are generally even worse than after other forms of child abuse, such as physical abuse. These are the results of research by Leiden psychologists,…

The overarching aim of this theme is to increase our understanding of the mechanisms underlying altered cognitive, affective, and social behavior in relation to mental health problems.

What role do parent-child interactions play in the development, maintenance and treatment of depression in young people?

Josien de Klerk and Tennessee Miller examined the interplay between students’ illness and recovery experiences and academic work culture in this context.

Chronic inflammatory skin diseases such as psoriasis and atopic dermatitis affect both the physical and psychological well-being of millions of patients, leading to persistent symptoms like itchiness and sleeplessness. These conditions often result in decreased productivity and quality of life overall,…

It may seem as though adolescents do as they please, but they are more sensitive to their parents’ opinions than they would appear. The adolescent brain reacts strongly to parental criticism or praise. These are the results of a study by an interdisciplinary research group of psychologists and neuroscientists…

What are the social and neural mechanisms that contribute to fluctuations in self-esteem in healthy adolescents and adolescents with depression?

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

To make the right clinical decisions or develop effective diagnostic tests and treatments, it is important to understand the underlying mechanisms of a condition or behavior.

Promotor: Prof.dr. J. den Hertog

The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterise and predict variation in treatment response and enhance translational drug development strategies.