5 search results for “optimise drug dosing” in the Public website
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The role of glomerular filtration and active tubular secretion in predicting renal clearance in children using population pharmacokinetic and
In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.
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Major study offers practical guidance on antibiotic dosing in patients with obesity
Leiden researcher Anne-Grete Märtson brought together a large number of studies to better understand antibiotic dosing in patients with obesity. The publication in a renowned medical journal has already garnered much positive reactions, Märtson says. ‘It’s high time researchers started sharing more…
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How do children's kidneys eliminate drugs?
What dose of medicine do you give a child? That depends to a large extent on how quickly their kidneys remove the drug from the blood. For ethical reasons it is impossible to measure this directly in little patients. PhD candidate Sinziana Cristea combined different types of modelling and lots of data…
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Improving painkiller dosing in the clinic
Children, cardiac surgery patients or people who are obese. How can we improve the dosing of painkillers for these patients? Hospital pharmacist Sjoerd de Hoogd of the St. Antonius Hospital in Utrecht investigated this. He combined data from the hospital with the knowledge and expertise of the Leiden…
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How to determine medication dosages for premature babies
Premature babies almost always require treatment with medication. Doctors usually determine the dosages based on data from children who were not born prematurely, while preterm infants often develop differently. Medication researcher Aline Engbers investigated three commonly used drugs, focusing on…