The HOPES study is one of the largest investigations of this kind to date! By studying existing brain scans and data collected form over 4,000 14-25 year olds, the project team hopes to identify specific changes in the brain that make young people vulnerable to suicidal thoughts and behaviours.

Exploiting the Ecological Role of Natural Products as Novel Biocontrol Agents (LIPQUORUM): The central aim of LIPQUORUM is to unravel the intricate interkingdom signaling mechanisms between the Bacillus subtilis species complex and the devastating fungal pathogen Sporisorium scitamineum.

The aim of the research programme Systems Pharmacology lies in the development of personalised medicine strategies, and development of new systems-based approaches in translational and clinical pharmacology.

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.

At the initiative of several of its professors, Leiden University has joined the international Healthy Universities network. Surrounded by space hoppers, the initiators of this move and those present exchanged experiences and tips at the kick-off meeting on 17 October. ‘I don't miss my chauffeur'…

Burnout is on the increase. It is caused by group pressure, being ‘on’ all the time and asking too much of ourselves. Clinical psychologist Bart Verkuil advises lowering our expectations.

Farmers do not love them all. Microbes can cause tragic consequences for crops. Even the presence of just one pathogenic fungus or bacterium can drastically reduce yields. Still, there are exceptions. In that case, a pathogenic microbe is present in the soil, but does not cause any harm. Adam Ossowicki…

Which genes are involved in woodiness and associated traits such as drought tolerance, flowering time, stem elongation, life span, and plant herbivory, and how do these gene regulatory pathways overlap?

What is the effect of pesticides, fertilizers or plastic on water quality? And how do wind and rain affect the data? These are just some of the things that Leiden environmental scientists study in the 32 ditches of the Living Lab.

In the research theme ‘Animal Sciences and Health’, we work with various animal species to gain insights into fundamental biological processes in both animals and humans.

LED3 is the combined effort of three excellent institutes of Leiden University. Through joined hands, we are able to give rise to a more effective early drug discovery pipeline. Let us briefly introduce the three institutes.

This thesis describes our search to identify and understand possible regulatory mechanisms of integrin α6β4 in cell-matrix adhesion and intracelular signaling.

The new project INFLANET will train young scientists in Europe to become experts in inflammation research. Professor Annemarie Meijer from the Institute of Biology Leiden coordinates the training.

PhD defence

The major aim is to determine the psychophysiological responses to stress and stress-management interventions and to examine the role of stress and stress-related psychophysiological mechanisms (e.g., cognitions, behaviors, and physiological stress responses) in both healthy and medical populations.

What are the genes and molecular mechanisms involved in bacteria-mediated plant drought tolerance?

Supervisor: Andrea Martella

The Leiden Institute of Chemistry organises and participates in several programmes for high school students and teachers.

Antimicrobial resistance (AMR) is the phenomenon that pathogens become insensitive to the antibiotics that we use against them. A growing number of pathogens is becoming resistant, with methicillin-resistant S. aureus (MRSA) as the most famous example. But while the threat of AMR represents a slow-moving…

The Leiden Institute of Chemistry (LIC) is the basis for research and collaborations of the Leiden chemistry groups. Chemistry is the central science enabling a healthy future in a sustainable society. Chemistry researchers at Leiden University take a fundamental approach in finding tailored solutions…

In this research group, headed by Prof. Erik Danen, the aim is to unravel cellular signaling mechanisms in normal and diseased cells, with a long-standing interest in cell adhesion signaling. In complex multicellular organisms such as ourselves, a division of labor emerges where different tissues and…

All research at Leiden University is organised into institutes. To do justice to the wide spectrum of research (and consequently teaching) that comes from these, you will find descriptions of all the Leiden institutes on these pages.

The Netherlands X-omics Initiative is a new facility as part of the National Roadmap for Large-Scale Research Infrastructures. It is partly funded by NWO with a total budget of 40 million euro. The project started on September 2018 and will last for ten years.

M. Danhof, Co-promotor: O.E. Della Pasqua

The Division of BioTherapeutics at the Leiden Academic Centre for Drug Research (LACDR) is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

Supervisor: Indira Nederpelt

The theme 'Health and well-being in a healthy society' is one of the focal points of the Faculty of Social and Behavioural Sciences (FSW). We are committed to promoting health and well-being for people of all ages.

Microbial Sciences' contribution to the Bioactive Molecules research theme is to discover new bioactive molecules and enzymes and unravel their mechanisms of action, regulatory networks, and the (bio)synthetic pathways required for their production.

Health psychologist Aleksandrina Skvortsova has made clever use of the Pavlov effect to link the ‘cuddle’ hormone oxytocin with the placebo effect. This effect can alter the level of oxytocin in the body, making it possible for people to reduce the amount of medicine they need while still feeling good.…

Leiden biologists have shown that a gene present in plants, animals and yeasts does play an important role in plants, although for years the gene was considered unimportant. It turns out the gene plays a crucial role in the development of vascular tissue in plants. Publication in Nature Plants on 11…

It is becoming increasingly clear that the placebo effect has a great influence on medical treatment. An international, interdisciplinary team of researchers led by Professor of Health Psychology Andrea Evers from Leiden University has now written a first set of guidelines on how to apply the placebo…

Harvesting rice from the same field, without planting new rice plants? A discovery may bring this scenario closer. Leiden scientists have discovered a gene that allows annual plants to grow after flowering, instead of dying. Publication on 13 April in Nature Plants.

The Royal Netherlands Academy of Arts and Sciences has elected five Leiden professors from different disciplines as new members. Two of the new members are women.

All living systems are assembled from nature’s repertoire of small, medium, and large organic molecules. This theme focuses on the study, discovery and development of novel bioactive compounds obtained from biodiversity. We aim for new insights into the role of these molecules in the natural environment,…

As a student of Bio-Pharmaceutical Sciences, you have a strong interest in drug development: from the onset of diseases to the effects of individual drugs in the body. Is that true for you? Then, Bio-Pharmaceutical Sciences might be the right study programme for you!

PhD defence

PhD defence

How humans and rats cohabit the cityscape and what consequences this has for both sides of the conflict?

The opportunistic bacterium Burkholderia cenocepacia is feared by cystic fibrosis patients and is emerging in hospital-acquired infections. An international study sheds new light on the infection mechanism of this opportunistic pathogen that may have large implications for treatment strategies.

Suddenly getting lost, failing to recognise family members, or forgetting words and names are well-known symptoms of Alzheimer's disease. Psychologists have now discovered that the disease also manifests in more subtle ways: through the rhythm of finger tapping.