This is an Erasmus+ International Credit Mobility project of the Leiden University Medical Center with Nagasaki University.

This is an Erasmus+ International Credit Mobility project of Leiden Law School with the University of Rwanda.

This is an Erasmus+ International Credit Mobility project of the Faculty of Humanities with the University of Hyderabad.

The ambition to have flexible learning pathways is about creating possibilities to improve the content and form of students’ learning process, and to link learning to students’ needs. Students who have access to a flexible range of learning pathways can align their university career with their own personal…

An international research consortium led by Bob van de Water, Professor of Toxicology at Leiden University, has been awarded a prestigious Horizon2020 grant of 30 million euros.

Supervisor: Anna Vlachodimou

The research conducted at the Leiden Academic Centre for Drug Research is clustered within the divisions of BioTherapeutics, Cell Systems and Drug Safety, Medicinal Chemistry and Systems Pharmacology and Pharmacy, and the Metabolomics and Analytics Centre.

The Leiden Science Young Talent Award is awarded yearly to a student who completed their bachelor’s degree with an excellent thesis.

At the division of Biopharmaceutics, we aim to develop and test new therapeutic approaches to limit or even prevent the development of atherosclerosis in order to reduce the number of acute cardiovascular syndromes such as myocardial infarction or stroke.

Throughout all domains of life, from bacteria and archaea to eukaryotes, genomes adopt well-organized three-dimensional structures that can change in space and time to accommodate preferred transcriptional programs for environmental adaptation, the maintenance of cellular identity and differentiation…

1. What is the exact role of PIN proteins in PAT? 2. How is PIN polarity established, and how is it modulated by AGC kinase-mediated phosphorylation? 3. What is the role of the AGC kinase, as modulators of PAT, in translating environmental signals, such as gravity, light or mechanical stress, to plant…

To get a feeling of how we operate at LED3 when it comes to Early Drug Discovery, please browse through our case studies. When you select a case study you’ll find relevant contacts.

PBDL favors multidisciplinary research. Depending on the problems under investigation, PBDL establishes collaborations between experts from for example molecular genetics, molecular and electro cell physiology, biochemistry, organic chemistry, analytical mathematics, mathematical statistics and computational…

Microbes influence and respond to other organisms. This theme explores the dynamic relationships within plant and animal microbiomes, and the immune responses that govern host defense. Using model systems such as zebrafish, insects, and plants, we investigate fundamental processes and engineer microbes…

What are key regulators of plant ageing that can reverse ageing in plants (rejuvenation), and how can we use this knowledge to improve crop plants?

This is an Erasmus+ International Credit Mobility project of the Faculty of Science with the Ethiopian Space Science and Technology Institute in Ethiopia.

This is an Erasmus+ International Credit Mobility project of Leiden University’s Faculty of Science with two Colombian universities, Universidad Nacional de Colombia and Universidad de Antioquia.

This is an Erasmus+ International Credit Mobility project of Leiden University Medical Center with the University of Havana.

This is an Erasmus+ International Credit Mobility project of Leiden University Medical Center and the Faculty of Science with two universities in Indonesia.

PhD defence

Promotor: A. Doelman, Co-promotores: P.J.A. van Heijster; A. Zagaris

The CIGR brings together a diverse range of unique expertise in genome research rooted in biology, chemistry and physics. Members of the CIGR investigate genome folding and genome transactions. An important aspect is direct as well as long term relevance for medicine. The available expertise extends…

High throughput microscopy

We use DNA strands to stabilize few-atom silver clusters, which show unique optical and chemical properties. This thesis involves the study of these constructs for various applications.

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

The LUMC iPSC Hotel offers the generation of research grade human induced pluripotent stem cells (hiPSCs) from different tissue sources using state of the art reprogramming techniques.

The Therapeutic Immunomodulation Group is led by Prof. Johan Kuiper. In this group we aim to identify novel immunologic targets and apply immunotherapy to inhibit or even prevent the development of atherosclerosis.

Chemical tools to monitor drug-target engagement of endogenously expressed protein kinases are highly desirable for preclinical target validation in drug discovery. Here, we describe a chemical genetics strategy to selectively study target engagement of endogenous kinases.

This thesis focuses on the synthesis, characterization and performance towards CO2 electroreduction of mono and bi-metallic particles based on p-block metals

In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

Promotor: Prof.dr. W. Jiskoot, Co-promotor: A. Kros

X-Ray Diffraction (XRD), Nuclear Magnetic Resonance (NMR) and Cryo-electron microscopy (Cryo-EM) are the three main methods for solving structures of macromolecules.

The Aging and Immunity group is led by Dr. Amanda Foks. In this group we aim to investigate how aged immune cells contribute to atherosclerosis and identify novel therapeutic targets and strategies to extend health span and inhibit cardiovascular disease.

Agrobacterium-mediated transformation (AMT) has abundantly been used for scientific research for identifying valuable traits.

Key publications of the Aging and Immunity group

MT3 is a globally unique programme led by professors and expert authors that covers the most up-to-date knowledge possible in the area of Classical Transfusion Medicine and Cellular and Tissue Therapy. It provides access to high quality knowledge and skills via a completely online system.

The Division of BioTherapeutics at the Leiden Academic Centre for Drug Research (LACDR) is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.

We are interested in understanding the mechanics of soft materials, of which biological materials are prominent examples.

The Leiden Institute of Chemistry (LIC) is the basis for research and collaborations of the Leiden chemistry groups. Chemistry is the central science enabling a healthy future in a sustainable society. Chemistry researchers at Leiden University take a fundamental approach in finding tailored solutions…

Source: Mol Psychiatry (2015)

Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

Living systems scale from unicellular microbes to complex multispecies communities that constantly change over time. Within the theme Development & Disease, we enhance our fundamental understanding of development and homeostasis of living cells and systems. We analyze the normal situation and how stresses…

How can we develop new chemical biology tools and approaches to understand and interfere with glucosylceramide metabolism in relation to Gaucher disease?

The Microscopy Unit houses, maintains and coordinates most of the microscopy equipment of the IBL. The available equipment ranges from conventional light and fluorescence microscopes, to confocal laser scanning and electron microscopes. In addition, infrastructure is available for histology, including…

Honorata Mazepus and Jaroslaw Kantorowicz are assistant professors at the Institute of Security and Global Affairs. Mazepus and Kantorowicz are one of the authors of this article in Nature on the role of national identity on public health support during global pandemics.

This is an Erasmus+ International Credit Mobility project of the Faculty of Science with Sichuan University in Chengdu.

On 16 January 2020, Maaike Wensveen defended her thesis 'Eigen haard is goud waard?'. The doctoral research was supervised by Prof. P. Nieuwbeerta and Dr. J.M.H. Palmen.

This is an Erasmus+ International Credit Mobility project of Leiden University’s Faculty of Governance and Global Affairs with Fukushima University.

This is an Erasmus+ International Credit Mobility project of the Faculty of Sciences with one partner in Ukraine.