Supervisor: Anna Vlachodimou

Chemotherapy that does nothing until you irradiate it with light. Sylvestre Bonnet receives a Vici grant of 1.5 million euros for the development of this treatment. The Leiden chemist wants to build a new molecule to fight tumours that are at the time still difficult to treat.

Some people are predisposed to develop cancer. Mutations in genetic material that increase a person’s chances of developing cancer can already be present at birth. Researchers are closely examining these mutations to learn more about how cancer begins to develop.

Cognitive decline (amongst other problems with attention, concentration, memory) is a common symptom in patients with a variety of brain disorders and has been related to healthy ageing as well. People suffering from cognitive deficits are often significantly hampered in their day-to-day functioning…

Fundamental research teaches us how our brain decides to eat one more sweet, instead of doing exercise. A public information campaign about healthy lifestyle has little impact on the decision, as Professor of General Psychology Bernard Hommel is aware. However, he does know what works. But the question…

Leiden has a long history in the treatment of blood cell cancer. Research to find better therapies never stands still. One of the potential treatments currently being worked on is a ‘living medicine’.

More and more medicines are becoming available that target a tumour’s specific traits. The use of chemotherapy is continually undergoing improvement.

The majority of scientists, from archaeologists through to zoologists, collect huge volumes of data. Their massive databases contain large amounts of information which is difficult for humans to filter. With a solid grounding in statistics, we can develop algorithms for analysing and identifying patterns…

Providing each cancer patient with the right treatment remains a challenge. Oncode Accelerator aims to change this by innovating the way we develop cancer treatments, thus ensuring the patient is at the heart of the process. Leiden University, the LUMC and other partners will implement this new way…

Since itch and pain can be very burdensome, especially when individuals suffer from (either of) these symptoms chronically, it is important to know the factors by which these sensations are influenced. It becomes more and more clear that psychological factors play an important role in the experience…

The Access & Support Platform is a network of disability experts by experience, i.e. staff and students, at Leiden University.

Treatment with special stem cells seems to be a good option for suppressing the immune system in organ transplants. Researchers are trying to learn from processes that take place in the human body during pregnancy.

Does the political context (e.g., democracy vs. authoritarianism) influence what makes people perceive authorities as legitimate?

Master Health, Ageing and Society: tackle ageing population, innovating and improving elderly care, care for ageing population, health systems, wellbeing & policy. Prepare for future healthcare and societal challenges.

Role models are key to inspiring the next generation. Fifteen female professors therefore celebrated International Women's Day with girls aged between 12 and 16. Because although the number of women at the (academic) top is increasing, we're not there yet.

Promotor: S.M. Verduyn Lunel

Health Data Science Leiden University

Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

How can mentors and social workers foster the vocational identity of at-risk youth and improve their prospects?

A major goal of ABS research is to overcome one of the major bottle-necks in metabolomic research: the lack of a high-throughput infrastructure in which thousands of samples can be processed in a standardized and cost-effective way (max. a few tens of Euro’s per sample for a full metabolome profile).…

The group Clinical Neurodevelopmental Sciences has expertise in individual differences in child development, in particular the development of psychopathology, ranging from mild to severe neurodevelopmental disorders.

Would you like to know more about our research using laboratory animals or our studies on alternatives to animal testing? If so, take a look at the news articles on the right-hand side of the page (for mobile users, see the bottom of the page).

On 1 April 2020, Ivan Romashchenko defended his thesis 'Related Party Transactions and Corporate Groups: When Eastern Europe Meets the West'. The doctoral research was supervised by Prof. S.M. Bartman en Prof. A. Radwan (Kaunas, Lithuania).

Promotores: J. Jonkers, K.E. de Visser

Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.

The goal of the research presented in this thesis was to explore the chemical space of ruthenium(II) photocages, investigate their ability to host potent chemotherapy drugs, and to red shift the activation wavelength of the most promising PACT candidates to conduct biological studies.

Promotores: Prof.dr.G.R. de Snoo and Dr. R. Heijungs

The main aim of this dissertation was to provide insight into possible subtle forms of bias in youth socialization by various socializing agents in the Netherlands, and exploring new ways to document bias. Additionally, it addresses the importance of using sound statistical methods for calculating effect…

Vinasse is a major by-product generated by the sugarcane biofuel industry. It is a source of microbes, nutrients and organic matter and often it is recycled as fertilizer.

I want to understand the overlap between physical health, mental health, and healthy aging and whether/how stress (behaviorally and biologically) may tie these concepts together.

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

Prostate cancer (PCa) is one of the most prevalent cancer in males.

This is the first full-scale reference grammar of Classical Greek in English in a century.

Breast cancer is the most common cancer in women worldwide. Metastasis, the process by which cancer cells spread to other parts of the body, makes treatments less effective. It is important to unravel the mechanism of metastasis.

The Supramolecular & Biomaterials Chemistry group comprises the PIs Alexander Kros, Roxanne Kieltyka, Gregory Schneider and Sander Wezenberg, and is active in the field of self-assembly of amphiphilic peptides and applying them in supramolecular chemistry.

Argumentation and rhetorics is the study of how we convince people verbally. In other words, what do people say and how do they say it?

Develop a prototype combined chemical-microbial enzymatical process for the sustainable, green recycling and revalorization of polyamides and polystyrene

Source: Org Biomol Chem, Volume 13, Issue 8, pp. 2407-22 (2015)

Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh

Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…

In this thesis, the role of mast cells in atherosclerosis and novel therapeutic strategies to inhibit atherosclerosis progression are discussed. The first part of the thesis specifically focuses on the relation between mast cells and advanced human atherosclerotic plaque characteristics.

This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.

Growth and development affect the metabolism of drugs administered to neonates, infants, and children.

If you wish to know exactly what is going on in a healthy or sick human body, and at various levels such as molecule, cell, tissue, organ, larger systems and a person as a whole? Do you wish to learn how to do research which contributes to diagnoses, treatment and prevention of diseases? Then the bachelor…

Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea

Promotores: C.A.J. Knibbe; J.N. van den Anker, Co-promotores: H.P.A. van Dongen; B. van Ramshorst

English The purpose of this research is to identify and examine the challenges faced by African States in the field of foreign investment with a view to contribute not only to the academic debate, but also to foster awareness and develop the capacities of these States with regard to the drafting, negotiation…