Within this project, PeptoMiktoStars were realized through an orthogonal protecting group strategy and should be investigated further regarding their potential as drug delivery systems in the field of drug delivery to inflamed areas in cancer, bacterial infections or autoimmune diseases.

Promotor: Prof.dr. T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier

The lipid matrix in the stratum corneum (SC), the upper layer of the skin, plays a critical role in the skin barrier. The matrix consists of ceramides (CERs), cholesterol (CHOL) and free fatty acids (FFAs).

Promotor: Prof.dr. M. Danhof

Structure-affinity relationship (SAR) and structure-kinetics relationship (SKR) studies were combined to investigate a series of biphenyl anthranilic acid agonists for the HCA2 receptor.

Timely, adequate and optimal treatment of infectious diseases is essential for the survival of patients with bacterial infections (Surviving Sepsis campaign).

The barrier function of the skin is primarily provided by the stratum corneum (SC), the outermost layer of the skin. Skin barrier impairment is thought to be a primary factor in the pathogenesis of atopic eczema (AE).

A new research line is the development of liquid biopsy fingerprints to predict early Alzheimer’s disease (AD) stage in human in readily accessible body fluids in human (in collaboration with: Dr. Geert-Jan Groeneveld, CHDR; Prof. Elga de Vries, Free University Medical Center; and others).

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

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Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.

Pancreatic ductal adenocarcinoma (PDAC) is among the cancers with the highest mortality rate, despite a relatively low incidence.

Antimicrobial resistance is one of the biggest threats to human health worldwide in the coming decennia.

Breast cancer (BC) is a clinically and biologically heterogeneous disease.

The Chemical Biology & Immunology (CBI) group is headed by Prof. Sander van Kasteren and Prof. Kim Bonger.

The skin barrier function is provided by the stratum corneum (SC). The lipids in the SC are composed of three lipid classes: ceramides (CERs), cholesterol (CHOL) and free fatty acids (FFAs) which form two crystalline lamellar structures. In the present study, we investigate the effect of CER chain length…

A consortium of research groups, including that of LACDR professor Erik Danen, will use an NWO Perspective grant of nearly five million euros to build a universal standard for organ-on-chip models. They aim to stimulate the application of these chips in the biomedical and pharmaceutical industry. Danen…

Though tuberculosis can be cured today, new resistant strains of the bacteria are becoming a growing problem in the medical world. Biologist Annemarie Meijer and her colleagues are studying resistance to this disease. Their research is already yielding several interesting clues that could help the development…

In this thesis, we describe the potential of cell mechanical phenotyping for immune cell characterization, diagnosis, drug testing, as well as treatment of disease.

In vitro disease models play a fundamental role in drug research. They enable the systemic identification and validation of disease mechanisms and the discovery of possible drug targets. However, more than often, drug candidates that are identified in vitro fail in the later clinical stages of drug…

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The objective of the Next Generation ImmunoDermatology project (funding NWO, program NWA-ORC) is to deep profile the immune-mediated inflammatory diseases: i) atopic dermatitis (AD), ii) cutaneous lupus erythematosus (CLE) iii) chronic spontaneous urticaria (CSU) iv) hidradenitis suppurativa (HS) v)…

Chronic inflammatory skin diseases such as psoriasis and atopic dermatitis affect both the physical and psychological well-being of millions of patients, leading to persistent symptoms like itchiness and sleeplessness. These conditions often result in decreased productivity and quality of life overall,…

Pharmacogenetics is nowadays increasingly incorporated in the clinic to better predict pharmacokinetics and optimize dosing regimens of drug treatments. While this approach has been successful and improved our prediction of drug metabolism, drug levels within patients may still commonly deviate between…

On this page you can find information about previous CCLS events.

Lecture

Leiden Professor of Translational Rheumatology Hans Ulrich Scherer has one foot in the clinic, where he helps patients, and the other in the lab, where he supervises researchers. He bridges these two worlds in his hunt for autoimmune rheumatic diseases.

Leiden University, the LUMC and Janssen have signed a partnership agreement stating that they will collaborate in different areas, including infectious disease prevention, clinical tests, drug production and e-health. By joining forces, the three partners will be able to provide better, more innovative…

Methods of treatment for chronic illnesses are limited. Doctors and researchers at Leiden University Medical Center (LUMC) and Leiden University are working on new therapies as an alternative for organ transplants. The goal is to cure the illnesses by restoring organs to their original function. Stem…

This is an Erasmus+ International Credit Mobility project of the Faculty of Science with the Taras Shevchenko National University of Kyiv.

From black holes to artificial intelligence and from drug research to data science: welcome to the fascinating world of the Faculty of Science. Our researchers, students and guests regularly give public lectures about their work. You are welcome to attend.

Exploring metabolomics-based biomarkers for diagnosis and treatment response monitoring of community-acquired pneumonia

There are eight institutes at the Faculty of Mathematics and Natural Sciences:

This project is part of the Next Generation ImmunoDermatology (NGID) consortium, which focuses on the comprehensive phenotyping of six different immune-mediated inflammatory skin conditions. A common factor contributing to these diseases is a dysfunctional skin barrier. The skin barrier function is…

This thesis describes our search to identify and understand possible regulatory mechanisms of integrin α6β4 in cell-matrix adhesion and intracelular signaling.

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