Authoritative and cutting-edge, Bacterial Chromatin: Methods and Protocols, Second Edition aims to be a useful up-to-date reference work for researchers currently in the field and to those entering the field.

Dynamic nuclear polarization with paramagnetic agents can enhance nuclear magnetic resonance signals by orders of magnitude. The mechanism of enhancement depends a.o. on the magnetic resonance properties of the agents used. Electron spin relaxation times at NMR relevant magnetic field/microwave frequencies,…

Endocannabinoids are lipid messengers that modulate various physiological functions by activating the cannabinoid CB1 and CB2 receptors. While the metabolism of endocannabinoids and their action at the CB receptors is fairly well studied, the molecular mechanisms governing their release and transport…

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

The Faculty of Science is housed in various buildings situated in the Bio Science Park Leiden.

Source: J Med Chem, Volume 57, Issue 8, pp. 3213-22 (2014)

Promotor: A.P.IJzerman Co-promotor: A. Bender

Given the accelerating appearance of antimicrobial resistance, there is an urgent need for more fundamental research into novel antibiotic strategies. The work in this thesis helps to address this global problem by developing new antibiotic compounds, inspired by the antibacterial mechanisms of the…

The thesis focuses on synthesis strategies in oligosaccharide campaigns, and the influence of protecting groups.

This thesis covers various applications of topology in condensed matter physics and quantum information.

This thesis tackles the urgent challenge of antimicrobial resistance (AMR) through the design of novel antibacterial agents.

Promotor: Prof.dr. M. Ubbink

N-acylethanolamines (NAEs), including N-arachidonoylethanolamine (anandamide, AEA), N-palmitoylethanolamine (PEA) and N-oleoylethanolamine (OEA), are signaling lipids that play an important role in different physiological process.

The studies described in this thesis deal with glycosidases, in particular alpha-galactosidases.

Many biological processes occur by biomolecules coming together and organizing into specific clusters without being bound to each other. These interactions range from clustering, transiently interacting (kiss and run), or assembling to multimeric units that can only function in conjunction. The hydrogen…

Promotor: Prof. dr. A.G.G.M. Tielens

Authoritative and cutting-edge, Bacterial Chromatin: Methods and Protocols aims to be useful as an up-to-date reference work for scholars in the bacterial chromatin field, those entering the field from adjacent research fields, and scientists in the eukaryotic chromatin field.

What do scholars do when they talk about virtues (impartiality, accuracy) or vices (dogmatism, prejudice)?

This specialisation combines advanced training in mathematics at a world-class institute with interdisciplinary courses on high-tech instrumentation and design and an industrial placement, preparing you for a career in which you develop and apply sophisticated mathematical techniques to innovations…

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

Diacylglycerol lipases (DAGLα and DAGLβ) convert diacylglycerol to the endocannabinoid 2-arachidonoylglycerol. Our understanding of DAGL function has been hindered by a lack of chemical probes that can perturb these enzymes in vivo.

Astronomers want to understand the Universe, from the Big Bang to the present day, and what the future will hold. In Leiden they focus on two key questions: ‘How did stars and planets originate’ and ‘How were galaxies and black holes formed in the young Universe?’ A new generation of telescopes – just…

Improved molecular knowledge of the mechanisms of processes in the cell can lead to better medicines and new or advanced methods for combating diseases. Our MSc students in Life Science and Technology (LST) specifically learn to understand the molecular and structural chemical and biological aspects…

Interested in the BSc Science for Sustainable Societies at Leiden University? Please check our admission requirements.

In 2022, many of our staff and students won fantastic prizes and were awarded important research grants.

The greatest challenges facing humanity today have significant global dimensions that require substantial policy responses at a planetary scale. In this context, the Multistakeholder Global Governance (MGG) project aims to understand to what extent and under what circumstances multistakeholder global…

This year, the International Institute of Air and Space Law (IIASL) attended the first days of the 41st Assembly of the International Civil Aviation Organization (ICAO).

Leiden University is demolishing a number of old laboratories of the Faculty of Science in a sustainable way. The Dutch Green Building Council, an organisation that seeks to ensure sustainable construction and demolition, awarded this approach four stars.

Read about experiences of former students.

This research focuses on the (Quantum) Dynamics (QD) of the reactive scattering of H2 from metal surfaces.

He’s a fast and animated speaker, which is only logical because Gerard van Westen is driving an express train. His destination? A virtual human, consisting of algorithms that predict what an administered substance will do in the body. The train is already a long way down the line and the pharmaceutical…

Biological chemist Nathaniel Martin is going to test an alternative antibiotic that can combat common resistant bacteria such as MRSA. For this purpose, he will receive 350,000 euros from the NWO's NACTAR programme. ‘We want to know how safe and effective our antibiotic is in a realistic situation.’

Dr Bela Bode receives a Feodor Lynen research fellowship for postdoctoral researchers by the Alexander von Humboldt-Foundation for development of new methods for signal enhancement in solid state NMR. He aims to create a specific analytical tool for surface studies and research on membranes and membrane…