Assistant Professor at the Department of Analytical Chemistry, Radboud University Nijmegen, the Netherlands

This thesis focuses on the synthesis, characterization and performance towards CO2 electroreduction of mono and bi-metallic particles based on p-block metals

Hydrogen peroxide (H2O2) generation via electrochemical oxygen reduction is a sustainable production method for this bulk chemical. However, the selectivity of molecular catalysts for electrochemical H2O2 generation has hardly been investigated in a systematic manner, and it is unknown if their stability…

Promotor: Prof.dr. M. Ubbink

We report new computational and experimental evidence of an efficient and astrochemically relevant formation route to formaldehyde (H2CO). This simplest carbonylic compound is central to the formation of complex organics in cold interstellar clouds and is generally regarded to be formed by the hydrogenation…

Before the large scale use of renewable energy sources can be implemented in our society, the storage of electrical energy needs to be tackled. Storage the energy as hydrogen via the reduction of protons is a good option.

This perspective addresses four challenges facing theorists whose aim is to make quantitatively accurate predictions for reactions of molecules on metal surfaces, and suggests ways of meeting these challenges, focusing on dissociative chemisorption reactions of H2, N2, and CH4.

Pancreatic ductal adenocarcinoma (PDAC) is the deadliest common cancer, with only 8% of patients surviving for five years. One reason for this poor outcome is that current chemotherapy treatments are highly toxic, often leaving patients too sick to receive treatment or forcing doctors to lower the dose…

In surface science there is great effort to move from studying simple, flat model surfaces in vacuum to investigating more complex model catalysts in gas environments (in situ). This thesis gives three examples of such studies using microscopy and spectroscopy.

Promotor: Prof.dr. G.J. Kroes

Promotor: E. Bouwman, Co-Promotor: S. Bonnet

Promotor: E. Bouwman, Co-promotor: S. Bonnet

Promotor: E. Bouwman, Co-promotor: S. Bonnet

On this page you can find information about previous CCLS events.

Hermen Overkleeft and his colleagues Gideon Davies (University of York) and Carme Rovira (University of Barcelona) will receive a 9.1 million euros Synergy Grant from the European Research Council. Together, they will form the Carbocentre Synergy team for research into enzymes that work on glycans:…

Over 170 SUNRISE’s stakeholders gathered on June 17-18 at the Academy Palace of Brussels, in connection with the EU Sustainable Energy Week, as one of the Energy Days. Renewable energy experts from Academia, Industry and Policy addressed the current state of the initiative and its priority research…

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

Activity-based protein profiling (ABPP) is a functional proteomics technique for directly monitoring the expression of active enzymes in cell extracts and living cells. The technique relies on irreversible inhibitors equipped with reactive groups (warheads) that covalently attach to the active site…

This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.

This thesis focuses on developing new chemical synthesis strategies to produce native ADP‑ribosylated biomolecules with precise structural control.

This thesis investigates innovative and classical strategies in glycoconjugate vaccine development to address the growing threat of multidrug-resistant bacterial infections.

This thesis aims to investigate the effect of tripartite interaction between microbial inoculants, the plant, and herbivore insects on the rhizosphere microbiome and volatilome. We investigated the rhizosphere microbiome and volatilome of tomato plants exposed to insect herbivory and/or inoculated with…

The Role and Effectiveness of the G20. In this article, published in The Changing Global Order part of the United Nations University Series on Regionalism book series, author Jaroslaw Kantorowicz discusses the evolution of the G20.

This is an Erasmus+ International Credit Mobility project of the Faculty of Science with the Taras Shevchenko National University of Kyiv.

The Data-Driven Drug Discovery Network (D4N) is an initiative by researchers from Leiden University and collaborators to join efforts in applying and developing novel techniques from data science to drug discovery and related topics from bioinformatics.

Did he dare take a gamble with his PhD research? Jeroen Methorst didn’t have to think long about it. It could fail or turn out very well. The latter is the case. Methorst developed a computer system that helps researchers find the protein they need. ‘Our whole group is now using this program.’ Methorst…

The National Roadmap for Large-Scale Research Facilities programme of NWO enables the building or renovation of research facilities with international allure. Leiden NMR groups take part in the uNMR-NL consortium coordinated by Marc Baldus (Utrecht University) that has been awarded almost 18 million…

Lecture

Conference

Twenty years from now, the world population is estimated to be around 9 billion people (now 8 billion). In combination with the improvements in living standards and the corresponding growth in consumption, this population will result in an enormous increase in the demand for food, consumables, water…

Which teacher did an outstanding job in not only transferring knowledge in novel ways but also in getting students enthusiastic and connecting a course to current research themes? Meet the nominees for the Teacher of the Year Award 2024!

How do pathogenic mycobacteria alter lipid metabolism in human cells and patients, and which disrupted pathways could be targeted for new antibiotics?

Meet the scientists within the LED3 community

Source: International Journal of Cosmetic Science, Volume 37, Number 1, pp. 148-148 (2015) ISBN: 0142-5463

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

In the emerging field of small-molecule RNA targeting, there is a growing demand for new high-throughput screening methods.

Are you the scientist of the future? Come experiment with science at the Experiments Square! Make your own slime, discover how rubber can count, play along with the antibiotics game, discover the power of light and much more!

Lecture

Developing safer alternatives to harmful PFAS filters and seeking new enzymes for medical applications. Two projects with Leiden researchers have been awarded funding through the Dutch Research Council's (NWO) Open Technology programme.

Are you interested in taking up an extra challenge during your master’s programme?

Jacques Waisvisz (98) is one of our oldest living alumni. As a Jewish student in the Second World War, he was forbidden from completing his studies. How does he look back at that time, and what was life like afterwards? ‘No one thought that the situation here would become so bad.’

Plants use sunlight to perform photosynthesis, but with too much light they have to dim their activity and protect their cells against photo damage. The protein PsbS acts as a light-stress sensor and plays a key role in this process. Article in Nature’s Scientific Reports.

Promotor: Prof.dr. G.P. van Wezel

In 2024, many of our students and staff won great prizes and secured important research grants.

Many researchers of the Faculty of Science are members of a research school related to their area of expertise. Research schools aim at collaboration of researchers from different faculties in the same university (interfaculty schools) or in different universities (interuniversity schools).

All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).

Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.

The mechanism of the electrochemical reduction of dioxygen by a mononuclear pyridylalkylamine copper complex was investigated (see picture). It was shown that in neutral aqueous solution dioxygen undergoes stepwise reduction, wherein hydrogen peroxide plays a key role. The rate constants determined…

Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.