2,460 search results for “een lacdr” in the Public website
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Bestraffing
Leids onderzoek naar bestraffing komt tot stand uit verschillende disciplines. Het onderzoeksproject kent een juridische, criminologische, sociaalwetenschappelijke en filosofische invalshoek.
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Admission requirements
The master’s degree programme Education and Child Studies is an academic, not a vocational programme. It offers research-based knowledge about education and child development.
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Online library
Immerse yourself: read books, listen to podcasts and watch films about racism, discrimination and the colonial past.
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Lespakket over sterren en hun vele betekenissen
Gratis te downloaden voor het onderwijs: een inspiratie- en lespakket over stervormen hun symbolische betekenis en hun rol in verschillende culturen en godsdiensten.
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Scanning mutagenesis in a yeast system delineates the role of the NPxxY(x)(5,6)F motif and helix 8 of the adenosine A(2B) receptor in G protein
Source: Biochem Pharmacol, Volume 95, Issue 4, pp. 290-300 (2015)
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Immunotherapy to limit atherosclerosis
Atherosclerosis is a chronic inflammatory disease, and vaccination may be an attractive method to induce long lasting protection against endogenous factors that contribute to the development of atherosclerosis. We have shown that for example vaccination against modified LDL or interleukin-12 limits…
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Proteochemometric modelling coupled to in silico target prediction
An integrated approach for the simultaneous prediction of polypharmacology and binding affinity/potency of small molecules.
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Kinetic profiling of positive allosteric modulators of the mGlu2 receptor
Supervisor: Maarten Doornbos
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Pharmacometabolomics; prediction of system-wide multi-biomarker drug response
The lack of success of new CNS drugs in clinical development is in part due to the complexity of the CNS, unexpected side effects, difficulties for drugs to penetrate the brain, but also by the lack of biomarkers.
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Cancer Drug Target Discovery
We focus on a better understanding of the mechanisms of cancer drug resistance and metastasis.
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Covalent inhibitors of G protein-coupled receptors: the case of adenosine receptors
Supervisor: Xue Yang
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Polypept(o)ide-based nanostructures for therapeutic and diagnostic application
Nanoparticles exhibit a number of adjustable properties, e.g., their size, shape, and surface and core chemistry, which can be further diversified with different functional moieties. This opens a broad field for application in diagnostic and therapy. In this respect, the use of a polymeric hybrid material,…
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Research with animals
At Leiden University, in both our biomedical and biological research, we use laboratory animals. Learn more about these specific areas of research and the goals we aim to achieve through these studies.
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Proteochemometrics
Research question
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Quantitative Systems Pharmacology
This research area is focused on the development and application of novel concepts and models in the emerging area of quantitative systems pharmacology (QSP).
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Leiden2022
Leiden was European City of Science in 2022: for a year Leiden was the capital of European science. Leiden University was a proud partner of Leiden2022.
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Kinetics for Drug Discovery: a Case for the Adenosine A3 receptor
Supervisor: Lizi Xia
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Sheathless capillary electrophoresis-mass spectrometry as a new approach for analyzing the polar metabolome
Metabolomicshas emerged as an important discipline to study molecular and cellular processes in living cells and organisms with the ultimate aim to obtain an answer to a given biological/clinical question.
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Delivery of Biotherapeutics
The Delivery of Biotherapeutics research group is led by Prof. Matthias Barz and focusses on the synthesis and characterization of polypept(o)ids and their application in nanomedicine to improve existing therapies or enable novel diagnostic or therapeutic approaches.
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United States
This is an Erasmus+ International Credit Mobility project of Leiden University’s Faculty of Science with University of California.
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Participants
The CIGR comprises research groups from the Leiden Institute of Chemistry (LIC), the Leiden Academic Centre for Drug Research (LACDR) and the Leiden Institue of Physics (LION).
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SALTSWAT Project
SALTSWAT -- a project which combines the Spaces for Active Learning & Teaching and the Support wtih Active Teaching -- began in Mid-2019 and is running in pilot until the summer of 2020. The purpose of the project is to find answers to the question of how to systematically accelerate 'active teaching…
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Physicochemical analysis of allosteric binding pockets
Supervisor: Gerard van Westen
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Sodium ion binding pocket mutations and adenosine A2A receptor function
Source: Mol Pharmacol, Volume 87, Issue 2, pp. 305-13 (2015)
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Prediction of binding kinetics
Supervisor: Gerard van Westen
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Intracellular allosteric modulators for human CC chemokine receptors
Supervisor: Natalia Ortiz Zacarías
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PKPD and disease modelling in therapy development for amyotrophic lateral sclerosis (ALS)
We aim to gain a better understanding of the natural disease progression of ALS in order to improve clinical trial design and analysis and to support drug discovery and clinical development of new drugs.
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Bio-Pharmaceutical Sciences (MSc)
The master’s programme of Bio-Pharmaceutical Sciences at Leiden University examines the research area of bio-pharmaceutical sciences and drug research. It offers seven specialisations ranging from BioTherapeutics to Industrial Pharmacy.
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The aging B cell landscape in atherosclerosis
In this thesis, single-cell approaches were applied to characterize the impact of aging on the immunological B cell landscape in different models of atherosclerotic cardiovascular disease, with the goal to identify and study new B cell-associated biomarkers and therapeutic targets to halt atherosclerosis…
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Drug safety Sciences
Our research in the area of safety sciences aims to increase the mechanistic understanding of cellular toxicity of drugs and, in a broader sense, chemicals.
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Mutation-Driven Modulation of GPCR Pharmacology: Insights from Adenosine and Serotonin Receptors
This thesis seeks to investigate how cancer-associated mutations affect the pharmacological properties of selected GPCRs—primarily A2AAR and 5-HT2CR—through a combination of ligand binding assays, signaling readouts, kinetic profiling, and cellular functional assays.
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Synthesis and biological evaluation of spirocyclic antagonists of CCR2 (chemokine CC receptor subtype 2)
Source: Bioorg Med Chem, Volume 23, Issue 14, pp. 4034-49 (2015)
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Gut Microphysiological Systems for Toxicology: Scalable Assays for Industry Implementation
PhD defence
- Research output
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Flexibilisation, globalisation and technological change: consequences for labour markets and social security.
This research project is funded by a subsidy from Instituut Gak.
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About the Programme
During the two-year History Research Master's programme you will learn from inspired academics and learn how to conduct high quality research.
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Funnelbeaker Material Practices
Ongoing microwear analysis of the flint artefacts from the Funnelbeaker period suggests that flint had a pivotal role in the representation and structuration of the cosmological order of Funnelbeaker society.
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Probing the darkness: the link between baryons and dark matter
Promotor: Prof.dr. J. Schaye, Co-promotor: Marcello Cacciato
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A good start: Early prevention of anti-social behavior
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Education
The programme group Parenting, Child Care and Development carries out general courses within the field of Education and Child Studies and specialised courses within the field of Child and Family Science.
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Education
The bachelor's programme in Psychology in Leiden covers the full breadth of psychology. Our bachelor's students have the opportunity to specialise. Our master's students prepare themselves for a career as a ‘scientist - practitioner'. In the one year master's programme the emphasis is on practise; in…
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Broadening Youth Participation in STEM Learning
How can we broaden youth participation in STEM Learning
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Required documents
Along with your application, you will need to submit a variety of documents. This information only applies to students who need to submit an admission application. If you have a bachelor’s degree from Leiden University that grants you automatic admission to a master’s degree in the same field, you don’t…
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Awards and Grants 2025
On this page you will find an overview of awards and prizes granted to our staff and students in 2025, as well as special appointments at Leiden University and other institutions.
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Organisational & Entrepreneurial Behaviour
The research group Organizational & Entrepreneurial Behavior investigates the behavior of individuals and groups who start, work in, or lead organizations, in order to inform organizational practice. By focusing on the behavior of (groups of) employees, entrepreneurs and leaders, the main levels of…
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Moleculair mysterie in de ruimte
Tussen de sterren is niet alleen leegte. Er zweven ook stoffen als methanol en koolstofdioxide. Chemische theorieën kunnen nog niet verklaren hoe die zijn ontstaan onder omstandigheden die dat juist onmogelijk zouden moeten maken. Fedor Goumans gaat met een Veni-beurs proberen die vraag te beantwoor…
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Gebruiker proof of concept toegang Digitaal Magazijn KB
Voor deze use case zoeken wij een gebruiker die voor onderzoeksdoeleinden interesse heeft in de auteursrechtelijk beschermde collectie van de KB en ons kan helpen met het opstellen door wensen, noden en ervaringen te delen.
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Jenny AudringFaculty of Humanities
j.audring@hum.leidenuniv.nl | 071 5272247
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Roosje PeetersFaculty of Humanities
r.m.m.peeters@hum.leidenuniv.nl | 071 5272699
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Marieke AdriaanseFaculty of Medicine
m.a.adriaanse@lumc.nl | 071 5279500