The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.

Find out more about our national and international research collaborations.

Pathways of toxicity

Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.

Ecotox is a stimulating top-facility that provides an integrative research environment around the topic of ecotoxicological testing and experimental research. Research focus: Dose-response modelling Mode-of-actions and mechanism-of-actions Test method development, in view of targets in AOPs (adverse…

Microbial Sciences' contribution to the Biodiversity & Evolution research theme focuses on understanding how bacteria sense and respond to their environment, and how bacterial diversity and evolution is influenced by cooperative and antagonistic interactions taking place between microbes.

Gold nanorods are biocompatible nanoparticles that present an excellent two-photon signal that can be used to get high spatial resolution inside living cells. Gold nanorods are photostable and therefore can be followed inside cells for long time, with possible applications as trackers in live cells.

Source: ChemMedChem (2015)

This thesis presents the first synthetic peptides ADP-ribosylated on serine, threonine, tyrosine, arginine and cysteine.

In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.

Cancer represents a formidable current and future global health challenge. The LUMC medical research profile Cancer Pathogenesis and Therapy charges this challenge by developing and implementing innovative patient-tailored, multimodal diagnostic methods and treatment modalities.

PhD defence

The main aim of this research is to understand the dynamics of identity within indigenous Caribbean communities as expressed through the practice of intentional cranial modification. A multidisciplinary approach will be applied to achieve this aim, combining current anthropological and sociological…

Subjects Barbarian, Monstrous, and Wild responds to a contemporary political climate in which historically invested figures of otherness—barbarians, savages, monsters—have become common discursive currency.

If you can't make it to Leiden University to visit us, don't worry. Our virtual tours take you around the cities of Leiden and The Hague, show you around on campus and into our classrooms.

In late medieval and early modern times, books, as well as the people who produced and read (or listened to) them, moved between regions, social circles, and languages with relative ease. Yet, in the multilingual Low Countries, francophone literature was both internationally mobile and firmly rooted…

Leiden University is working on a green, circular campus, with a significant reduction in energy consumption by 2050 as its goal, as elaborated in the Route Map Energy Transition Buildings, published in 2022.

Both on a personal and institutional level, the staff of Leiden CADS collaborates with:

Publications resulting from the AFITE project

The miniaturization of machines towards the micron and nanoscale requires the development of joint-like elements that enable and constrain motion. We developed a facile method to create colloidal joints, that is, anisotropic colloidal particles functionalized with surface mobile DNA linkers that control…

Essays in archaeology, ethnohistory and ethnography of the Amerindian circum-Caribbean

A convolutional neural network (CNN) is a biologically inspired algorithm, highly capable at processing images and videos.

The Una Europa Clusters bring together leading experts and experienced staff from numerous academic and professional service departments across the Una Europa institutions.

The mobile lab, the Psychology Lab on Wheels, brings science to the general public!

The International Institute of Air and Space Law’s (IIASL) Research in Aerospace Law & Policy series features early-stage research, policy analysis and position papers. Published work includes preliminary findings, policy recommendations and institutional reports through which the IIASL aims to inform…

If you can't make it to Leiden University to visit us, don't worry. Our virtual tours take you around the cities of Leiden and The Hague, show you around on campus and into our classrooms.

Who had a say in making decisions about the natural world, when, how and to what end? How were rights to natural resources established? How did communities handle environmental crises? And how did dealing with the environment have an impact on the power relations in communities?

The main aim of the project is to collect and update on a regular basis bibliometric and patent indicators that can be used to underpin and inform analyses pursued at the European Commission (EC) to assess European and national scientific and technological performance.

The elderly accept may minor discomforts like stiffer muscles and getting tired more quickly, but they do want to go to their children's birthdays independently. Preventive elderly care helps people with that. The goal is to let people grow old while maintaining their self-reliance and independence…

Metal-containing molecules combine geometrical features and a reactivity that are inherently different from that of organic molecules. My research focuses on light-activatable metal-based anticancer drugs and metal-functionalized liposomes. Light is a very selective way to activate photosensitive drugs…

Promotor: P.M. Brakefield

Research at the Macromolecular Biochemistry group is comprised of the following research themes:

PhD defence

Turbulent times in Italy: Deputy prime minister Matteo Salvini wants new elections so that he can become prime minister himself. He is campaigning on social media, including photos of himself posing in his swimming trunks.

On Friday 23 February Jorrit Rijpma spoke at the Roundtable “Whispering in the Prince’s Ear?” at the University of Amsterdam.

On 19 and 20 February 2018, Melanie Fink and Jorrit Rijpma were invited to discuss questions of fundamental rights accountability at the Frontex headquarters in Warsaw.

Denmark, Poland and Germany are a few of the countries that have closed their borders, entirely or certain sections, in response to the continued advancement of coronavirus. Normally, this is only possible when there is a threat to public order or national security.

Seminar

On Wednesday 27 February, a group of around 30 Leiden Law students visited the EU’s Agency for the coordination of cooperation between police authorities, the European Police Office (Europol) in the world’s legal capital: The Hague.

On 28 and 29 June researchers from across the EU came together at Leiden Law School for the first MOSE Young Researcher Workshop.

On November 16th 2018 Jorrit Rijpma visited the European Parliament and the European Commission with students of the LDE Master on the Governance of Migration and Diversity.

On Thursday 7 March, a group of around 40 Leiden Law students visited the EU’s Agency for the coordination of cooperation between law enforcement authorities, the former European Police Office (Europol) in the world’s legal capital: The Hague.

Leiden researchers are helping develop safe COVID-19 vaccines.

The central theme of Rik Mom’s research group is to identify what the electrode-electrolyte interface looks like when electrocatalysis is taking place. Using specialized forms of Raman and X-ray spectroscopy, we study the chemical state and bonding environment of the electrode surface and near-surface…

The Delivery of Biotherapeutics research group is led by Prof. Matthias Barz and focusses on the synthesis and characterization of polypept(o)ids and their application in nanomedicine to improve existing therapies or enable novel diagnostic or therapeutic approaches.

In order to gain insight into the structure and function of the molecular complexes involved in chemotaxis, we use electron cryotomography (ECT). This technique allows us to directly study microbes in their native state at resolutions capable of visualizing individual proteins.

The CIGR comprises research groups from the Leiden Institute of Chemistry (LIC), the Leiden Academic Centre for Drug Research (LACDR) and the Leiden Institue of Physics (LION).

The Biomedical Metabolomics Facility Leiden (BMFL) is the core metabolomics facility of Leiden University and the Metabolomics and Analytics Centre (MAC). We offer a highly structured environment for advanced MS-based metabolomics studies and build on fully validated, state-of-the-art assays that each…

The first photo of a black hole and measuring anxiety in the brain... From 13 until 22 May we're serving a free slice of science with your pizza.