This volume sheds light on the role played by progeny in maintaining dynasties in early modern royal courts as well as the horizontal and vertical interplay between the actors. It attempts to break through the narrative of older research that saw dynasties as a series of male rulers. Instead, these…

What is the Fine Mechanical Department?

Tracing the residues of Neolithic activities through the study of stone artefacts

Promoting sustained physical activity through tailored incentive-based interventions for diverse cardiovascular disease patient groups.

On 14 December 2022, students of the course Social and Ecological Activism in the Visual Arts (as part of the Creative Strategies for a Society in Change minor) presented and performed their final collective project at BAK, basis voor actuele kunst, Utrecht: the Water Cultures Institute group role-playing…

While bioinformatics methods deal with the analysis of sequence information (be it proteins or DNA), the field of cheminformatics is concerned with the analysis of small-molecule datasets.

New or improved treatments for chronic and acute illness.

Als gevolg van de grote technologische vooruitgang in de gezondheidszorg worden in toenemende mate gegevens verzameld tijdens de uitvoering van klinische onderzoeken.

Source: J Cheminform, Volume 6, Issue 1 (2014)

NimbleAI aims at solutions for ultra-energy efficient and secure neuromorphic sensing and processing at the edge.

Supervisor: Indira Nederpelt

Can the offering of host community compensation help to prevent or solve siting controversies, and if so, why and under which conditions?

This editorial to RHCPP discusses how COVID-19 can be seen as a 'creeping crisis' according to the authors of its lead article (Boin et al, 2020) and how resilience may depend on the real heroes behind the scenes of response to disaster and adversity.

The Pharmacy research group focusses on the development of predictive models to improve clinical drug efficacy and safety. We work on clinical problems that require further mechanistic understanding and strive for ultimate benefit to patients.

In the near future oral polio vaccine (OPV) will be replaced by inactivated polio vaccine (IPV) as part of the eradication program of polio. For that reason, there is a need for substantial amount of safe and more affordable IPV for low-income countries. Bioneedles, which are biodegradable mini-implants,…

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M.R.V. Chaudron, Co-Promotor: M.T.M. Emmerich

Promotor: A.P. IJzerman

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman

The Division of BioTherapeutics at the Leiden Academic Centre for Drug Research (LACDR) is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.

The project seeks to develop an eco-design framework for single-use medical devices and packaging

Multi-objective optimization is an effective technique for finding optimal solutions that balance several conflicting objectives. It has been applied in many fields of our world, because practical problems usually have more than one desired goal. For example, developing a new vehicle component might…

Supervisor: Andrea Martella

The financial sector is an appealing target for hackers. For that reason, lawmakers and regulators are going to great lengths to make the sector more resilient to cyber attacks. One recent measure was the introduction of the Digital Operational Resilience Act (DORA). This new EU regulation is extremely…

Source: Mol Psychiatry (2015)

Source: Eur J Med Chem (2015)

Source: Biosens Bioelectron, Volume 74, pp. 233-42 (2015)

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

Source: Br. J. Pharmacol., Volume 172, Issue 3, pp. 940-55 (2015)

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

Organisation of the Leiden Institute of Physics.

Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…

This dissertation looks into the role of discretion granted by EU directives (Article 288 Treaty on Functioning of the European Union) in legislative decision-making and national transposition processes of these directives.

In an increasingly complex and security-challenged society, the CSM programme, Cybersecurity Governance, provides you with the theoretical and practical skills to understand the issues underlying security challenges and develop solutions for crisis and security management.

Source: Purinergic Signal., Volume 10, Issue 3, pp. 441-53 (2014)

n an increasingly complex and security-challenged society, the CSM programme, Governance of Violence, provides you with the theoretical and practical skills to understand the issues underlying security challenges and develop solutions for crisis and security management.

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In an increasingly complex and security-challenged society, the CSM programme, Governance of crisis, provides you with the theoretical and practical skills to understand the issues underlying security challenges and develop solutions for crisis and security management.

Source: PLoS ONE, Volume 10, Issue 3 (2015)

In an increasingly complex and security-challenged society, the CSM programme, Intelligence and National Security, provides you with the theoretical and practical skills to understand the issues underlying security challenges and develop solutions for crisis and security management.

In an increasingly complex and security-challenged society, the CSM programme, Terrorism and Political Violence, provides you with the theoretical and practical skills to understand the issues underlying security challenges and develop solutions for crisis and security management.

Promotores: A.P. IJzerman, H.W.T. van Vlijmen

The Executive Board is responsible for the management and administration of the entire University.

Are you curious about how science and technology contribute to a sustainable and innovative future? At Leiden University, you’ll explore the world of data, natural laws and living systems. From mathematics to artificial intelligence, from climate challenges to high-tech innovation: you’ll learn to analyse…

Are you curious about how science and technology contribute to a sustainable and innovative future? At Leiden University, you’ll explore the world of data, natural laws and living systems. From mathematics to artificial intelligence, from climate challenges to high-tech innovation: you’ll learn to analyse…

Many students receive their first job offer during or right after their Business Studies internship. After graduating you can also aim for a career in Bio-Pharmaceutical research.

Covid year 2021 might have felt somewhat less strange than the year before, but the virus still left its mark on University life and our students and staff. Fortunately there was also room for research, visiting dignitaries and in-person classes. And our social media accounts weren’t only about covid…

2024 has been an eventful year, and this is reflected in our social media posts. An overview of the most liked, most shared or most impressive posts.

If you know a crime is about to occur, should you be able to prevent it before it has even happened? This was one of the questions that was posed in light of predictive policing as a form of mass surveillance during the debate in the elective Governance of Crime and Social Disorder class of the Crisis…