Supervisor: Natalia Ortiz Zacarías

The Institute of Biology Leiden (IBL) is an internationally oriented institute for research and education in biology. We are part of the Faculty of Science at Leiden University.

Born in Europe roughly 100 years ago, quantum physics brought forth a veritable technological revolution through semiconductors, lasers, fibre optics, and many other technologies that are today ubiquitous in our lives. Now, during the second quantum revolution, Europe can take the lead once more in…

The close interaction between organic chemi stry and biology goes back to the late 18th century, when the modern natural sciences began to take shape. After synthetic organic chemistry arose as a discipline, organic chemists almost immediately began to pursue the synthesis of naturally occurring compounds,…

Education & outreach

PhD defence

PhD defence

On this page the programme and sessions can be found.

Lecture, Global Questions Seminar

Chromatin is an ubiquitous protein-DNA complex that forms the structural basis of DNA condensation in all eukaryotic organisms.

The aim of this thesis was to develop novel treatment strategies for different types of eye melanoma utilizing zebrafish models. We first establish orthotopic and ectopic xenograft models for uveal and conjunctival melanoma by engraftment of the immortalized cells derived from these tumors into zebrafish…

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: J.D.C. Codee

Cardiovascular diseases are still a major concern for the global health.

Promotor: M. Ubbink, Co-Promotor: R. T. Dame

Our group operates at the cross-roads of different disciplines: molecular and cellular microbiology, biochemistry, structural biology and biophysics. The group harbors expertise in a multitude of molecular and cellular approaches including:

Promotor: Prof.dr. E.J.J. Groenen

With an ageing population it is becoming increasingly important to find means to repair cells, tissue and organs through regenerative medicine.

A selection of recent publications from the Plant BioDynamics Laboratory.

In this thesis we investigated the ability of two-photon multifocal microscopy for single-molecule microscopy in live cells and organisms.

Promotor: J.G.E.M.Fraaije, Co-promotor: A. Kros

The research group of Silke Henkes at Leiden University. Part of the Leiden Institute of Physics (LION). The group studies the physics opf active materials.

The aim of this thesis is to explore the use of Bioorthogonal Antigens to study the cross-presentation pathway.

Mechanisms fro drug resistance

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

The group Theoretical Physics of Life Processes, led by Helmut Schiessel, focuses on the physics of chromatin, the DNA-protein complex that fills the nuclei of eukaryotic cells.

This thesis advance our understanding and the application of molecular catalysts relevant to the reduction of oxygen as well as reduction of nitrite.

An objective of this research was to achieve direct, well-defined and non-rate-limiting electron transfer between respiratory enzymes and the electrode surface by means of 'Q-wires'.

This thesis focuses on the design and synthesis of activity-based probes and inhibitors targeting enzymes involved in the degradation of specific plant glycans.

Promotor: Prof.dr. B. van de Water, Co-promotor: E.H.J. Danen

The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…

Assistant Professor at the Department of Analytical Chemistry, Radboud University Nijmegen, the Netherlands

Autopaghy is an intracellular degradation system which targets cytosolic components to lytic compartments for degradation and recycling of the building blocks of the cell.

Source: J Med Chem, Volume 57, Issue 8, pp. 3213-22 (2014)

SBB research focuses on the complex operational, organisational dynamics of technology-intensive sectors.

Promotor: A.P.IJzerman Co-promotor: A. Bender

Promotor: J.M. Memelink

The research groups within the biological, soft and complex systems research area study the physics of a broad range of biological and soft materials. This spans both experimental and theoretical research.

MHC class I and MHC class II molecules present peptides to the immune system to drive proper T cell responses. Pharmacological modulation of T-cell responses can offer treatment options for a range of immune-related diseases.

This thesis explores squaramide-based supramolecular polymers and hydrogels, enhancing their mechanical strength for 3D cell culture.

During the course of drug discovery translational steps are made.

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: Dr. L.H. Heitman

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.