Transport inspectorates are looking for novel methods to identify dangerous behavior, ultimately to reduce risks associated to the movements of people and goods. We explore a data-driven approach to arrive at smart inspections of vehicles.

Archaeozoology is the study of faunal remains that are recovered at archaeological sites.

Software development is a complex process. It is important that software products become stable and maintainable assets.

Promotores: Prof.dr. M. Franx, Prof.dr. M. Kriek (Univ. of California at Berkeley)

The dissociative chemisorption of methane on metal surfaces is of fundamental and practical interest, being a rate-limiting step in the steam reforming process. The reaction is best modeled with quantum dynamics calculations, but these are currently not guaranteed to produce accurate results because…

Microbial Sciences'contribution to the Development & Disease research theme is to perform world-class research to understand cellular morphogenesis, growth, development and virulence of microbes.

Formulation of biopharmaceuticals

In this dissertation, we work towards an experiment in which we aim to bring a micrometer sized magnet at the tip of a soft cantilever into a superposition.

This project aims to develop advanced data analysis methods for monitoring and increasing our understanding on biodiversity dynamics in nature reserves such as the Oostvaardersplassen.

This thesis investigates the relations between metabolism and anatomy through the use of Magnetic Resonance Imaging (MRI).

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

Radio jets are important to the evoultion of galaxies. However, it is still not fully understood how a radio jet can be triggered.

Snellius, Niels Bohrweg 1, 2333 CA, Leiden

During the course of drug discovery translational steps are made.

In this work the reconstruction of a tau neutrino signal in the KM3NeT detector is discussed.

Within the FSW, we have put together a core team with contacts in the individual Institutes and at the Faculty level.

The origin and evolution of galaxies are closely linked to many different physical phenomena.

In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.

In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…

Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov

The aim of this research area is to be able to predict human drug response on the basis of mathematical models that are developed using preclinical experiments and prior knowledge.

Leiden University is working on a green, circular campus, with a significant reduction in energy consumption by 2050 as its goal, as elaborated in the Route Map Energy Transition Buildings, published in 2022.

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

Promotors: Prof.dr. J. Zaanen, Prof.dr.ir. H. Hilgenkamp

Authoritative and cutting-edge, Bacterial Chromatin: Methods and Protocols, Second Edition aims to be a useful up-to-date reference work for researchers currently in the field and to those entering the field.

EnSMiRT seeks to harness expertise within the Una Europa alliance and foster collaborations between leading researchers working on several stages of the mineral value chain to address these pressing challenges head-on.

Chemical tools to monitor drug-target engagement of endogenously expressed protein kinases are highly desirable for preclinical target validation in drug discovery. Here, we describe a chemical genetics strategy to selectively study target engagement of endogenous kinases.

From now on, you can listen to the intriguing stories of our staff any time you wish! On this page you can find out more about the new podcast series of the faculty of Humanities.

Open Science and Recognition & Rewards come together in this university-wide programme.

Promotor: G. J. Kroes

The use of N fertilizers has increased worldwide in the past century. While this increased input of N has increased food productivity, it has also contributed to decreases in biodiversity, soil quality and environmental health, including increases in greenhouse gas emissions.

Southern Africa has a rich tradition of social history, one inspired by the tumultuous changes that have regularly convulsed the region from the 1780s onwards. Scholars have always sought to understand what these changes meant for everyday life and emphasised a perspective of marginal groups, how these…

For more information regarding ongoing research projects, please contact Dr. Ilze Bot.

Book Launch

In this PhD project, we focus on improving the effectiveness and efficiency of LMs with narrative data.

This book celebrates Maarten Mous, professor of African Linguistics at Leiden University.

This thesis advances automata learning, a key area in computer science, with applications in software verification, biological analysis, and autonomous technologies. It explores three main themes: first, it introduces a passive learning algorithm for generating compact probabilistic models from positive…

The goal of the LIACS Media Lab (LML) at Leiden University is to conduct state-of-the-art research in the areas of deep learning, artificial intelligence and computer vision.

The Public Policy and Innovation department of the Institute of Public Administration focuses on shaping, implementing, and evaluating policy through innovative approaches. Our goal is to tackle complex societal challenges by exploring technological advancements and creative policy tools.

In this thesis, we focus on novel proteins/mechanisms that regulate integrin-adhesion mediated mechano-transduction.

Dissochaeta Blume (Melastomataceae, tribe Dissochaeteae) is well-known as a scrambling plant genus found in Southeast Asia, where it is an inhabitant of the tropical rainforests or evergreen forests.

Evidencing academic policy to everyday practice from the Erasmus COALITION project

Dit proefschrift beschrijft een collectie aan alternatieve strategieën voor het begrijpen, ontwerpen en toepassen van lipide nanosystemen, waarin de rol van de bio-nano interacties centraal staan. In het bijzonder wordt gekeken naar de interactie van RNA-lipide nanosystemen, bekend van de toepassing…

In the past decade many population studies have been performed with the Atacama Large Millimeter/submillimeter Array (ALMA) to understand the bulk properties of protoplanetary disks around young stars. These population studies mostly consisted of low mass stars, with relatively few of the disks around…

MHC class I and MHC class II molecules present peptides to the immune system to drive proper T cell responses. Pharmacological modulation of T-cell responses can offer treatment options for a range of immune-related diseases.

Mechanisms fro drug resistance

In the traditional theory of linear elasticity, superposition dictates that the response of a material does not depend on the sequence of the applied mechanical actuations.

In this thesis, I studied the origin and evolution of the non-thermal radiation in merging galaxy clusters.

This thesis describes the importance of being able to control the selectivity of potential drug candidates.

A structural investigation of coiled coil peptides used as membrane fusogens, mimicing naturally occuring coiled-coil fusion proteins. Synthetic modifications have been made to alter lipid attachment, secondary structure and to insert photoactive azobenzene moieties for active control over coiled coil…