In Slaving Zones: Cultural Identities, Ideologies, and Institutions in the Evolution of Global Slavery, fourteen authors—including both world-leading and emerging historians of slavery—engage with the ‘Slaving Zones’ theory.

Psycho-physiological studies for health and disease.

Labbe

Lecture

This dissertation focused on computational methods based on first principles calculations using the Density Functional Theory (DFT) framework. Emphasis was laid on affordable methods that can provide a tradeoff between computational expense and accuracy.

The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.

The studies described in this thesis deal with glycosidases, in particular alpha-galactosidases.

There are different ways in which the faculties of Leiden University keep in touch with their alumni.

Promotors: Prof.dr. E. Bouwman, Prof.dr. E. Drent

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: Dr. L.H. Heitman

Lipid signaling is an essential biological event/process in a plethora of pathophysiological conditions. The underlying idea of this thesis is that many of the roles and the complex interplay of the individual signaling lipids in inflammatory processes and related conditions in health and disease is…

Find out where you as a staff member or manager can turn for support or a good chat.

This thesis mainly focuses on cross-modal retrieval and single-modal image retrieval via deep learning methods, i.e. by using deep convolutional neural networks.

Welcome to StatiCS: the Statistical Consultation Service. The goal of the service is to provide statistical support to PhD candidates and other researchers.

Promotor: Prof.dr. M. Ubbink

The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments.

When a star is born in our Galaxy, it is quite likely that it has formed within a massive cluster, which hosts numerous high-mass stars bathing their lower mass neighbours in UV radiation.

Essays in archaeology, ethnohistory and ethnography of the Amerindian circum-Caribbean

The aim of current study was to develop a dried inactivated polio vaccine (IPV) formulation with minimal loss during the drying process and improved stability when compared with the conventional liquid IPV.

Promotor: M.A.G.J. Orrit

The Early Upper Palaeolithic (EUP) record throughout Europe is characterized by major changes in human behaviour.

In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

Autopaghy is an intracellular degradation system which targets cytosolic components to lytic compartments for degradation and recycling of the building blocks of the cell.

The MicroSOS project is designed to bring together academic and industrial partners with different expertises to address challenges that agriculture is facing due to climate change and invests in the development of microbiome-based solutions towards more sustainable agricultural practices.

This thesis focuses on the synthesis, characterization and performance towards CO2 electroreduction of mono and bi-metallic particles based on p-block metals

Promotor: Prof.dr. W. Jiskoot, Co-promotor: A. Kros

Diacylglycerol lipases (DAGLα and DAGLβ) convert diacylglycerol to the endocannabinoid 2-arachidonoylglycerol. Our understanding of DAGL function has been hindered by a lack of chemical probes that can perturb these enzymes in vivo.

University Lecturer Ahab Bdaiwi:

Atopic eczema is a skin disease with increasing incidence currently affecting 25% of the paediatric population. In atopic eczema the skin barrier function is reduced. This barrier is formed by the outermost layer of the skin called the stratum corneum (SC). The SC consists of terminally differentiated…

In this thesis, we consider various (electro)chemical phenomena at surfaces and nanoparticles and their underlying atomistic processes, which we studied using first-principles methods such as density functional theory.

Reinforcement learning is a framework that enables agents to learn in a manner similar to humans, i.e. through trial and error. Ideally, we would like to train a generalist agent capable of performing multiple tasks and achieving various goals.

The KLM Urban Trail Series is a hugely popular series of running trails in the Netherlands that are a unique way to explore a city centre. This year Wijnhaven is opening its doors to the runners. Join in with the fourth edition of the KLM Urban Trail in The Hague on Sunday 7 July.

Promotor: Prof.dr. M. Ubbink

The programme group Forensic Family and Youth Care Studies is one of the six programme groups within the department of Child and Education Studies at Leiden University.

Patients share valuable advice and experiences with their peers in online patient discussion groups.

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

Projects within the theme ‘Computational Biology’ aim to employ mathematical or computational dynamical modelling approaches to discover novel concepts that are important for drug development.

This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars.

Promotor: Prof.dr. H.V.J. Linnartz, Co-Promotores: S. Ioppolo, H.M. Cuppen

Studies in current archaeological applications of remote sensing and non-invasive prospection methods edited by Hans Kamermans, Martin Gojda and Axel G.

Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. D. Tibboel (EMC, R’dam)

Despite being the second largest transmembrane protein family after GPCRs, the SLC superfamily has only gained significant attention in early drug development over the past decade.

Promotor: J.M. Memelink

The demolition of the high-rise building is ready. The remaining debris are removed and the area is cleared. For the demolition, the University applied the BREEAM evaluation method at the level of ‘Excellent’, which means that the demolition operations were carbon neutral and did not cause any form…

Promotor: J.G.E.M.Fraaije, Co-promotor: A. Kros

This thesis introduces the concept of

We investigate how radiation pressure can be used to influence the mechanical motion of a micro-mirror suspended from springs.

Human vocal communication and music perception represent advanced cognitive skills, seemingly innate and universal. These faculties encompass a range of perceptual and cognitive abilities. Cross-species research sheds light on the origins of musicality by investigating whether these traits are shared…

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.