Main challenges in skin vaccination are overcoming the stratum corneum (SC) barrier and targeting the antigen presenting cells (APC) in the epidermis and the dermis.

The work in this thesis has been focused on two subjects. The first is the assembly of alginate oligosaccharides and the generation of building blocks for the enzymatic synthesis of alginate, and the second is the total synthesis of large fragments of the zwitterionic SP1 polysaccharide.

Promotor: A.P.IJzerman Co-promotor: A. Bender

Monthly PhD Labs offer COI PhD researchers an opportunity to present their work and receive specific feedback about their projects in a supportive and collegial environment.

The work in this thesis demonstrates how to obtain an atomic-scale picture of a diverse set of complex surface structures observed using STM, under disparate conditions.

Nonadiabatic energy transfer from the translational motion (T) of a molecule impinging on metal surface to the metal’s electrons may determine whether the molecule can lose enough energy to adsorb or react.

Cities need to become greener, more biodiverse, and climate-resilient. However, many organisms that are vital for the functioning of urban green spaces and the wellbeing of urban citizens remain largely unknown.

Another research line is the development of a spatial CNS drug distribution model, by ultimately including the 3-dimensional anatomical organization of the CNS.

Gorlaeus Building, Einsteinweg 55, 2333 CC, Leiden

Our call for workshop proposals was met enthousiastically by various people, and we are happy to announce that the following four workshops were unanimously selected by the organising committee.

The directorate of Leiden Observatory consists of the Scientific Director, the Director of Education and the Director of Operations.

In this thesis, we developed new ways to use a technique called electroextraction (EE) to extract charged molecules from one liquid into another using an electric field.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

This book celebrates Maarten Mous, professor of African Linguistics at Leiden University.

The aim of this thesis is to explore the use of Bioorthogonal Antigens to study the cross-presentation pathway.

This is the team of LAPP:

Deficiency of glucocerebrosidase (GBA) underlies Gaucher disease, a common lysosomal storage disorder. Carriership for Gaucher disease has recently been identified as major risk for parkinsonism. Presently, no method exists to visualize active GBA molecules in situ. We here report the design, synthesis…

The thesis focuses on synthesis strategies in oligosaccharide campaigns, and the influence of protecting groups.

One of the main research focuses of the Hortus botanicus Leiden is to study how the current biodiversity we see today, has originated, changed, and developed over time. The Hortus wants to study the relationship between species in specific focal taxa and see how they have diverged over time.

Transcutaneous vaccination is attractive because it is non- or minimally invasive, pain free and the site of administration (skin) is easily accessible. What’s more, transcutaneous immunization can lead to a strong immune response owing to the presence of immune-competent cells in the skin.

Whispering Wind (Fluisterende wind), a sound artwork by Edwin van der Heide, is situated in the passage that cuts right under the P.J. Veth building of Leiden University.

Homicide followed by the suicide of the perpetrator often leads to shock and incomprehension. It has been suggested that media reporting on such cases could lead to an imitation effect.

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

In this article, Joris Larik and Richard Ponzio grasp the importance of the Summit of the Future to overhaul and strengthen multilateral cooperation in an age of deepening rifts and increasing competition between the great powers. This article argues that a failure to convene a meaningful and ambitious…

In this thesis we have discussed several parameters that affect the electrochemical conversion of enviromentaly harmful molecules such as nitrates and carbon dioxide to more valuable and less deleterious compounds, in order to cast light onto the mechanism of the reaction to achieve an efficient and…

Academy Building, Rapenburg 73, 2311 GJ, Leiden

Aluminium-based adjuvants, such as aluminium hydroxide and aluminium phosphate, are well-known for their immune-stimulating properties.

The RNA guided endonuclease based on the CRISPR/Cas system of Streptococcus pyogenus is a potent new tool for genome engineering in plants.

Appropriate animal models for intradermal vaccine delivery are scarce. Given the high similarity of their skin anatomy to that of humans, minipigs may be a suitable model for dermal vaccine delivery.

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Within this archive you find the collection of all LUC Newsletters published by the Communications Team of Leiden University College The Hague.

More than 500,000 students and nearly 100,000 university employees across Europe are part of our Una Europa community.

Together we can make science open. Find the next step that fits your journey here.

We teach several courses in the domain of Mind, Brain, and Education.

Oude UB, Rapenburg 70, 2311 EZ, Leiden

Promotor: Prof.dr. H.A.G. Wijshoff

Promotores: Prof.dr. G.F.A Kersten, Prof dr. J.A. Bouwstra

This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…

The database research community has made tremendous strides in developing powerful database engines that allow for efficient analytical query processing.

Errors are everywhere, and mechanical failures are especially common: buckled grain silos and cracked support columns are, justly, seen as an issue to be avoided.

In this Ph.D. thesis we study the interaction of low energy electrons with thin materials, namely layered materials (graphene, hexagonal boron nitride, molybdenum disulfide) and organic films. At these low energies the quantum mechanical wavelength of the electron wave function is in the order of a…

Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.

Promotor: K.H. Kuijken

This project aims at determining the market value of hydrogen peroxide (HP) that is produced via our electrochemical methods that have been developed as part of the ERC-StG Cu4Energy project.

FSW building, Wassenaarseweg 52, 2333 AK, Leiden

Promotor: Prof.dr. B. van de Water, Co-promotor: E.H.J. Danen

In

Our centre seeks to form a community which connects a network of academics of various disciplines, with organisations interested in public governance.

The Royal Academy of Art and the Royal Conservatoire together with the Academy of Creative and Performing Arts (ACPA) at Leiden University are developing a new platform for research in and with the arts, with an emphasis on collaboration.