Uncover novel antimicrobials with prospective health benefits for sea turtles.

Can furan-based resisn be degraded by microbial enzymes in combination with mild pre-treatment?

What is the effectiveness of two school-based skills-training programs in promoting mental health?

Previous research has found important inter-individual differences in the pharmacokinetics (PK) of morphine in special populations such as children, the morbidly obese or the critically ill.

This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.

Cell-based medicinal products (CBMPs) show great promise when it comes to the treatment of genetic disorders. However, there is limited knowledge about CBMP stability during their production, storage, and administration to patients. The main focus of my research is the characterization of CBMPs using…

The project aims at highlighting and strengthening Dutch research into the diversity of the world’s languages from a historic and a cognitive perspective.

The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

In this thesis chemical and physical processes in the ice mantles on interstellar dust grains are studied.

Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

The current dissertation presents a review study and three empirical studies, focusing on the understanding of the state of the art of research about PjBL in higher education and the investigation of the relation between PjBL and student outcomes in the context of Chinese higher education.

Human skin equivalents (HSEs) can be a valuable tool to study aspects of human skin, including the skin barrier, or to perform chemical or toxicological screenings.

Although it is often assumed that the stereochemistry in Ugi multicomponent reactions is determined in the final Mumm rearrangement step, experimental and computational evidence that Ugi reactions on hydroxylated pyrrolines proceed under kinetic control is reported.

This study helped to identify and summarize how value-based healthcare (VBHC) is conceptualized in the literature and implemented in hospitals. Furthermore, an overview was created of the effects of both the implementation of VBHC and the implementation strategies used.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

In this project we investigate how the professional development around the theme of inquiry based teaching of teachers from three international schools takes place.

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

To what extent can contingent, formative feedback in lectures, facilitated by web-based ICT, increase students’ self-efficacy and (academic, behavioral, and cognitive) engagement? And how are self-efficacy and engagement influencing students’ performance and course evaluations?

Over the last decades, aviation safety has improved strongly. As a downside, airline pilots do not have as many opportunities to develop through experience the competencies that they need in critical situations.

Tin electrodeposition applications have rapidly evolved in the past 25 years.

New and reemerging infectious diseases call for innovative and efficient control strategies of which fast vaccine design and development represent an important element.

Cell-based medicinal products (CBMPs), such as CAR T cells, are highly complex biopharmaceutical products offering various treatment options for serious illnesses such as cancer or autoimmune diseases.

Promotor: Prof.dr. B.R. Katzy, Co-promotor: R. Ortt

Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh

What are the key technical, social, regulatory, economic, and ethical considerations for scaling up ocean-based Carbon Dioxide Removal (CDR) approaches, and what integrated assessment frameworks and governance structures are needed to facilitate their implementation at scale?

Promotores: W. Jiskoot, F. Ossendorp

Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk

Why does one person radicalize to involvement in terrorist violence within a group-based context, while another engages in this form of violence alone?

Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.

Activity-based protein profiling (ABPP) is a functional proteomics technique for directly monitoring the expression of active enzymes in cell extracts and living cells. The technique relies on irreversible inhibitors equipped with reactive groups (warheads) that covalently attach to the active site…

Seasonal influenza vaccines provide protection against matching influenza A virus (IAV) strains mainly through the induction of neutralizing serum IgG antibodies. However, these antibodies fail to confer a protective effect against mismatched IAV. This lack of efficacy against heterologous influenza…

We describe certain birational modifications of nodal relative curves over a regular base of arbitrary dimension.

ERC StG SAFE and SOUND has the ambition to connect the policy cycle with data generated in robot testing zones to support evidence-based policymaking for robot technologies.

Does the δ-machine have higher accuracy than the other feature-based classifiers in some conditions?

This dissertation is concerned with the development of grammar. Starting from a usage-based perspective, which holds that children use domain-general learning mechanisms to acquire the grammatical patterns of their mother tongue, Beekhuizen shows how to operationalize various concepts from this tradition…

Building a Deep Cross-media Transfer Network to extract visual relations that relieve the problem of insufficient training data for visual tasks.

uman skin equivalents (HSEs) are in vitro 3D-skin models that mimic many aspects of the native human skin (NHS) and can be a valuable tool.

Hydrogen peroxide (H2O2) is an important bulk chemical that is used in various industrial processes. More than 95% of the H2O2 used in industry is made via the anthraquinone process during which a large amount of energy is going to waste.

Can a newly developed, app-based, personalized maintenance program enhance the effectiveness of the exposure-based one-session-treatment for children with a specific phobia?

In design optimization problems, engineers typically handcraft design representations based on personal expertise, which leaves a fingerprint of the user experience in the optimization data. Thus, learning this notion of experience as transferrable design features has potential to improve the performance…

Sprayable plant-based adhesives for crop protection against thrips Some plants, such as sundew and tomato, protect themselves with sticky hairs that repel or even trap arthropod herbivores.

In this dissertation, we study partition-based models that can be used both for interpretable predictive modeling and for understanding data via interpretable patterns.

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

Analysis of drug adversity

With the emergence of online social networks (OSNs), the way people create and share information has changed, which becomes faster and broader than traditional social media.

What is students’ engagement in problem-based learning (PBL) and case-based learning (CBL) in teacher certification programs?

The surface and the edges of graphene are expected to provide higher sensitivity and specificity in detecting and characterizing single molecules. However fundamental physical limits exist in reaching an ultimate precision in detecting the dynamics of chemical and biological systems. The research in…