991 search results for “breast cancer” in the Public website
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Cell Systems and Drug Safety
The research within the Division of Cell Systems and Drug Safety, headed by Prof. Bob van de Water, is focused on novel therapeutic modalities and novel concepts in early drug discovery, in order to develop more effective and safer therapeutic strategies. We generate advanced cell and computational…
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Computational modeling of cellular dynamics in tumor cell migration
Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.
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Classical conditioning to improve immunotherapy in cancer
Can the conditioning paradigm be used for checkpoint inhibition cancer treatment?
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Science for Society
By carrying out fundamental research and providing excellent education, universities become a breeding ground for innovation and entrepreneurship.
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Discovery of metastasis promoting candidate drug targets
Discovery of metastasis promoting candidate drug targets
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Borderline between cancer and thrombosis
Winning a prestigious award for PhD researchers, even before you have your doctorate: that's what Yascha van den Berg managed to do with his research proposal on alternatively spliced tissue factor, a protein that may be involved in tumour growth. Van den Berg: ‘It all started as a Friday afternoon…
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3D-printed mini-tumours: a leap forward in improving cancer immunotherapy
Leiden researchers have developed a groundbreaking model to advance cancer immunotherapy. Using a 3D printer, they create mini-tumors within an environment that closely mimics human tissue. They have also developed a method to monitor real-time interactions of these mini-tumours with immune cells during…
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Liposome-based synthetic long peptide vaccines for cancer immunotherapy
Promotores: Wim Jiskoot; Ferry Ossendorp
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Risk assessment tools and adjuvant therapy for breast cancer
PhD defence
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Breaking barriers: unraveling response mechanisms to immunotherapy in breast cancer
PhD defence
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Predicting outcomes of breast cancer treatment in older patients
PhD defence
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Risk assessment tools and adjuvant therapy for breast cancer
PhD defence
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The immune system in action against cervical cancer
In the hunt for a vaccine against cervical cancer, fundamental knowledge about the immune system and organic chemistry have been brought together and have already resulted in a vaccine that is now being tested in clinical trials. Scientists are now working hard on an improved variant.
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A community effort to assess and improve drug sensitivity prediction algorithms
Source: Nature Biotechnology, Volume 2014, Issue June (2014)
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Regulation of signal transduction pathways by hypoxia in breast cancer subtypes
PhD defence
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Key publications
Key publications of the Cancer Drug Target Discovery group
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Cell-autonomous and host-dependent CXCR4 signaling in cancer metastasis: insights from a zebrafish xenograft model
Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska
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Topic: The placebo and nocebo effects of communication
We study how communication can heal and harm when patients are confronted with an illness. Most of our studies focus on serious illnesses such as advanced cancer. Communication lies at the heart of medicine, yet we do not always know which specific communication helps patients. Moreover, many complaints…
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Supporting women with breast cancer in making an informed decision about immediate breast reconstruction
PhD defence
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LED3 Lecture: Cancer Drug Discovery
Lecture
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Systemic Immune Dynamics in Cancer
PhD defence
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Accelerated Partial Breast Irradiation in elderly patients with early-stage breast cancer
PhD defence
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Cancer patients want a doctor who shows empathy and doesn’t make vague promises
Patients with incurable cancer want their oncologist to be clear but to show empathy too. They find hard and vague communication harmful. These are the results of a study by psychologists from Leiden that has been published in the American journal Cancer.
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Monitoring Cytoskeletal Conductance Variation for Sensing Cancer Drug Resistance
Actin and microtubules form cellular cytoskeletal network, which mediates cell shape, motility and proliferation and are key targets for cancer therapy. Changes in cytoskeletal organization correlate with proliferative capacity and invasiveness of cancer cells. These changes expectedly lead to altered…
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Upconverting nanovesicles for the activation of ruthenium anti-cancer prodrugs with red light
Promotor: E. Bouwman, Co-promotor: S. Bonnet
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Acquired resistance in pancreatic cancer: characterization and exploration of actionable targets of a multifactorial disease
PhD defence
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Unlocking the secrets of DNA repair: Sarah’s curiosity might lead to new cancer treatments
How do cells repair their damaged DNA—and what happens when that process is hindered and cancer arises? Sarah Moser has taken a closer look during her PhD, uncovering surprising insights that could help improve future cancer treatments.
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Multifaceted Roles of Grainyhead-like Transcription Factor- 2 in Breast Cancer
PhD defence
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Development of a universal delivery system for tailor-made cancer vaccines
The potential of liposomal cancer vaccines
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The good? The bad? The mutant! Characterization of cancer-related somatic mutations and identification of a selectivity hotspot in adenosine
G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.
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Video lecture: What is cancer?
Cancer is still one of the most common diseases in the world. What exactly is cancer and will we one day be able to cure everyone? In a video from the Universiteit van Nederland Noel de Miranda (Tumour Immunology, LUMC) tells you about his research on new treatments.
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PLGA-based particulate vaccine delivery systems for immunotherapy of cancer
Promotores: W. Jiskoot, F. Ossendorp
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Molecular Pharmacology
In this research group, headed by Laura Heitman, novel receptor concepts in drug discovery are studied, aiming to increase the effectivity of medicines. Many drugs act via so-called G protein-coupled receptors (GPCRs) and therefore our research is mainly focused on understanding and improving drug-receptor…
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Phenotypic screening with 3D cell-based assays
Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.
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Psychology student starts crowdfunding for cancer PhD research
'We believe that developing a protocol to help people fight cancer is extremely valuable, given that cancer is such a prevalent and devastating disease. If you believe so too, you can support us in realising this mission.' Master's student in Psychology Saskia Heijnen starts crowdfunding to make her…
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xenograft model: identification of novel mechanisms driving prostate cancer metastasis
Prostate cancer (PCa) is one of the most prevalent cancer in males.
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Using Liposomes; Opportunities for Treatment of Atherosclerosis and Cancer
This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.
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Healthy ageing
The elderly accept may minor discomforts like stiffer muscles and getting tired more quickly, but they do want to go to their children's birthdays independently. Preventive elderly care helps people with that. The goal is to let people grow old while maintaining their self-reliance and independence…
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BRCA1-associated breast cancer: finding new weapons for an old villain
PhD defence
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Attitude Switch: unraveling breast cancer cell-intrinsic mechanisms that manipulate the immune system
PhD defence
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Patient-derived models of breast cancer: A breakthrough story of the duct
PhD defence
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Disrupting the transcriptional machinery to combat triple-negative breast cancer
PhD defence
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Immunosuppression in breast cancer: a closer look at regulatory T cells
PhD defence
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Is a cancer pill a matter of time?
A cancer pill, preferably without severe side effects, is something we’d all welcome. Is it a matter of time before such a pill is a reality? We put this question to three Leiden researchers and asked how they themselves are contributing to new cancer treatments.
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Aggressiveness of cancer cells halted
Zebrafish-human communication shows that cancer cells lacking a signaling protein are less able to develop aggressive metastatic properties. This discovery has been made by molecular cell biologist Claudia Tulotta. PhD defence 14 June.
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Specialised immune cells have potential for new cancer immunotherapies
Researchers from Leiden University Medical Center (LUMC) and Netherlands Cancer Institute (NKI) have discovered how specialised immune cells can detect and remove cancers that are ‘invisible’ to the conventional defence mechanisms of the immune system. Their work has been published in Nature. The findings…
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Stefano Coppola Receives AXA RF Fellowship to Study Pancreatic Cancer
Leiden biophysicist Stefano Coppola has received the prestigious AXA Research Fund postdoctoral fellowship. With this grant he can work for two years on a project to research the role of mechanical factors in the development of pancreatic cancer.
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Light and nanoparticles against cancer
Leiden PhD student Xuequan Zhou has designed a new promising molecule that efficiently kills cancer cells, but does not harm healthy tissue. The trick: the drug is only active when irradiated with light. Zhou’s new compound does this extra efficiently by cleverly self-organising into nanoparticles.…
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Helping cancer patients with treatment choices
Researchers at the Leiden Institute of Advanced Computer Science (LIACS) are collaborating on the development of a conversation tool for patients with breast, prostate and skin cancer. The aim is to create a conversation tool that can support cancer patients in their care and help them make decisions.…
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Leiden Science Young Talent Award
The Leiden Science Young Talent Award is awarded yearly to a student who completed their bachelor’s degree with an excellent thesis.