Multiple Sclerosis, Parkinson’s and Alzheimer’s disease are the most common neurodegenerative disorders. Unfortunately, no effective treatments are currently available to halt the progression of these neuroinflammatory diseases [1].

How can we develop new chemical biology tools and approaches to understand and interfere with glucosylceramide metabolism in relation to Gaucher disease?

An important hormone excreting gland in the human body is the pituitary

Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.

Focus in skin research

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

Alzheimer's disease (AD) is the most frequent neurodegenerative disorder and the primary cause of dementia. The neuropathological features of AD include the occurrence of senile plaques, neurofibrillary tangles, decreased synaptic density, and loss of neurons. An obstacle in the study and treatment…

The modification of risk factors and related health behaviors lies at the very core of adequate cardiovascular risk management, yet evidence shows that the majority of people with cardiovascular disease (CVD) fail to achieve a healthy lifestyle in the long term. The main objective of this project is…

Nanoparticles can be used as delivery systems for both small molecules and macromolecules such as proteins, peptides or oligonucleotides. This thesis focuses on the use of liposomes, nanometric vesicles formed by a lipid bilayer enclosing an aqueous core. Liposomes are highly versatile delivery syst…

A new research line is the development of liquid biopsy fingerprints to predict early Alzheimer’s disease (AD) stage in human in readily accessible body fluids in human (in collaboration with: Dr. Geert-Jan Groeneveld, CHDR; Prof. Elga de Vries, Free University Medical Center; and others).

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

Accelerating the diagnosis and personalising the management of inherited metabolic diseases.

A main goal of MSBB research is to address the major bottle-necks in combatting viral diseases: the lack of experimental models that are representative of human pathology and are cost effective and versatile. Viral diseases such as those that cause viral hemorrhagic syndromes or severe acute respiratory…

To explore the potential of marine microorganisms as producers of novel antimicrobial agents and as bioprotectants in aqua- and agriculture, using an integrative, ecology-based strategy for bioprospecting.

Improving health, enhancing well-being and reducing health disparities across society.

As far as Daniël Pijnappels, Professor of Cellular Electrophysiology, is concerned, both researching and inventing are essential for a scientist.

How are the epidermal lipid pathways involved in health and disease.

The master’s programme of Bio-Pharmaceutical Sciences at Leiden University examines the research area of bio-pharmaceutical sciences and drug research. It offers seven specialisations ranging from BioTherapeutics to Industrial Pharmacy.

PhD defence

PhD defence

PhD defence

The ambition of the Metabolomics and Analytics Centre led by Thomas Hankemeier is to develop innovative analytical strategies for metabolomics-driven health monitoring and systems biology studies. Understanding the intricate balance between health, disease and adaptation to challenges relies on the…

At Leiden University, in both our biomedical and biological research, we use laboratory animals. Learn more about these specific areas of research and the goals we aim to achieve through these studies.

The Leiden Academic Centre for Drug Research (LACDR) is a centre of excellence for multidisciplinary research on drug discovery and development.

We know this, but we don’t act on it: eat healthily, move more, address our stress levels and sleep well. Internist and Professor of Diabetology Hanno Pijl is fascinated by the effect that a healthy lifestyle can have on health. He researches how this lifestyle is achievable and satisfying, for patients…

Promotor: H.J.M. de Groot, Co-Promotor: A. Alia

Leiden University researchers and their collaborators report the development of new research frameworks that use day-to-day smartphone behavior gathered from a large sample of healthy people to help understand aging, and how aging alters with epilepsy and stroke. These reports occupy two back-to-back…

The emergence of complex diseases resulting from abnormal cell-cell signaling and the spread of infectious diseases caused by pathogens are significant threats to humanity. Unraveling the dynamic mechanisms underlying cell-cell signaling and infectious disease spreading is crucial for effective disease…

PhD defence

In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof. dr. A.H. Meijer

Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

To make the right clinical decisions or develop effective diagnostic tests and treatments, it is important to understand the underlying mechanisms of a condition or behavior.

Exploring the landscapes of mental health and cardiometabolic research.

Health workers have always sought ways to fight disease in vulnerable groups in the population. It is now clear that such research also benefits more prosperous countries. African worm infections and innovative thermometers have shown Leiden researchers how to fight diseases of affluence and keep health…

Up to 50% of individuals with Parkinson's disease develop cognitive impairment over time; this study explores the use of 'practice effects' on neuropsychological tests as an early predictor of cognitive decline.

Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…

We aim to gain a better understanding of the natural disease progression of ALS in order to improve clinical trial design and analysis and to support drug discovery and clinical development of new drugs.

Each year on or around International Women’s Day, the university hosts the Annie Romein-Verschoor Lecture. You are welcome to attend − even if you wouldn't call yourself a feminist, says professor and organiser Nadine Akkerman. ‘You get the best discussions with a diverse audience.’

Which brain cell does what, when Parkinson's disease arises? It won't be long before this jigsaw is solved piece by piece. Ahmed Mahfouz, computational biologist, combines bio-knowledge from Leiden with algorithms from Delft and is getting closer to finding the key.

The Delivery of Biotherapeutics research group is led by Prof. Matthias Barz and focusses on the synthesis and characterization of polypept(o)ids and their application in nanomedicine to improve existing therapies or enable novel diagnostic or therapeutic approaches.

The ideas underlying this thesis are that lipidomics may improve the diagnosis of liver metabolic diseases, and can provide further insights into the underlying pathophysiology of these diseases.

Cardiovascular diseases are a leading cause of death worldwide, and better models are urgently needed for disease progression studies and drug development.

The aim of this project is to explore the use of statistical interaction models to quantify cross-omics and omics-drug interactions in large-scale clinical and experimental datasets

What does it mean to eat healthily and responsibly? This question is gaining a new urgency now that in many countries undernourishment is being overtaken by diseases of affluence, such as obesity, and we are also becoming more aware of the environmental impact of our eating habits. It’s time to take…

kiem grant: Investigating the anti-inflammatory potential of the PRG4 protein in preventing and alleviating rheumatoid arthritis