Despite the history of studies on methanol formation from CO2, the dominant elementary reaction steps that constitute the chemical mechanism for this catalyzed process are not determined.

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

Vibrating carbon monoxide molecules adsorbed at the surface of a salt crystal stop moving after a few milliseconds. Scientists now discovered this is dominantly due to the emission of electromagnetic waves. The role of the chemical bond at the surface thereby appears to be less important than previously…

The increasing resistance of pathogenic bacteria to antibiotics necessitates the discovery of new medicines.

Promotor: P.G.L. Klinkhamer, Co-Promotores: K. Vrieling, P.P.J. Mulder

Is the quality of the current supervision and enforcement by the government such that companies that work with large quantities of hazardous substances are brought into compliance with legislation and regulations?

Global healthcare is on the verge of an antibiotic availability crisis as bacteria have evolved resistance to nearly all known antibacterials. Identifying new antibiotics that operate via novel modes-of-action is therefore of high priority.

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Testing chemical substances without using animals. It seems a utopia, but a European team is going to develop a way to make this a reality. The RISK-HUNT3R project, led by Leiden professor Bob van de Water, received 23 million euros from the European Commission for this purpose. The project was launched…

An international team of researchers, including Federico Calle-Vallejo of Leiden University’s Institute of Chemistry, have taken the atomic-scale design of catalysts to the next level. Their research contributes to the quest for a method to generate or store energy more efficiently. The report is published…

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Plant exudates appeared long time ago in the history line of life in the early Devonian. They are typical saps produced by specialized cells.

A group of chemists, that includes Sander van Kasteren and Hermen Overkleeft, has discovered that azides, a certain type of chemical compound, can determine whether or not T cells respond to or ignore a vaccine. Their discovery is set to be published in Angewandte Chemie.

Thomas Bakkum en Tom van der Wel, two PhD candidates from the Leiden Institute of Chemistry, have both won poster prizes at the EMBL Chemical Biology Conference 2018 in Heidelberg.

Toxys, Leiden University and Leiden University Medical Center have agreed immediately to commercialise and also develop further the ToxProfiler technology invented at the two institutions. ToxProfiler allows for rapid toxicity hazard identification of novel and existing drugs, chemicals, and other substances.…

What chemicals do plants have available, and what happens if they use them when faced with bacteria or fungi? That is what PhD candidate Luis Salomé Abarca is keen to learn. He studies plants’ survival and their use of chemical components in communication and defence. Salomé Abarca works at the Natural…

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If you could convert CO2 into building blocks for other molecules with the help of electricity, you could make the chemical industry considerably more sustainable. Leiden chemists have unravelled a fundamental part of this process and applied this knowledge in a real device, as they write in Nature…

The American Chemical Society’s Publication Division (ACS) and Dutch universities represented by the VSNU have reached agreement on including open access publication as part of the contract with publishers. From 2017, all new articles submitted by an author associated with a Dutch university or participating…

Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.

Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…

Promotor: J.G.E.M.Fraaije, Co-promotor: A. Kros

De positie van kunst en kunstenaars in de westerse samenleving

The Dick Stufkens Prize 2018 for the best PhD thesis of the Holland Research School of Molecular Chemistry (HRSMC) will be awarded to Dr Stefan Vuckovic. In his thesis, Vuckovic presents a new and innovative approach to the quantum mechanical calculation of atomic and molecular energies. It lays the…

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

The bacterium Vibrio cholerae is a serious threat to our health because it is the causative agent of cholera. Worldwide, over a billion people per year are at risk of cholera infection. New strains of V. cholerae are resistant to the multiple drugs used to treat cholera, meaning that new types of drugs…

This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…

A difficulty of studies on chemical kinetics are the reaction time scales and detection of their intermediates.

Tackling key challenges of Chemical Biology and Medicinal Chemistry to aid drug discovery is one of the focus areas of Leiden University. To this end, the Leiden Early Drug Discovery & Development network (LED3) was established by the Leiden Institute of Chemistry (LIC), the Institute of Biology Leiden…

De decentralisaties van de zorg aan langdurig zieken en ouderen, jeugdzorg, en werk en inkomen die vanaf 2015 zijn doorgevoerd in Nederland hebben geleid tot een transitie van een centraal naar een lokaal stelsel van zorg en welzijn. Deze transitie beoogt zorg en ondersteuning dichter bij de inwoners…

In Democratie en totalitarisme zijn de invloedrijkste opstellen van de Franse denker Claude Lefort samengebracht. Lefort laat overtuigend zien dat de kwetsbaarheid van de democratie juist ook haar kracht is. Voor democratie is essentieel dat de macht als ‘lege plaats’ verschijnt. Zij mag slechts tijdelijk…

BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

This thesis investigates the relations between metabolism and anatomy through the use of Magnetic Resonance Imaging (MRI).

This thesis investigates the evolution and fate of gaseous exoplanets, which are continuously shaped by stellar activity across both short and long timescales.

This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

By growing in a soil plants change the biotic and abiotic properties of the soil in which they grow.

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

The Leiden Leadership Centre is an international and interdisciplinary network organisation connecting people and perspectives.

Systematisch geordend naslagwerk voor alle stadsrechten in Nederland

HZ Kenniscentrum Zeeuwse Samenleving doet op vraag van regionale overheden en maatschappelijke organisaties onderzoek naar actuele en maatschappelijke thema’s in de provincie Zeeland. De uitkomsten van onderzoeken en analyses worden gebruikt voor kennisopbouw en als basis voor beleidsopbouw en -ontwikkeling.…