The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

The more opportunities a child has to learn and develop, the stronger his or her future position in society. Leiden University investigates how the brain picks up information, and how learning processes can be influenced positively.

Can effective synergists be identified to enhance the effect of antibiotics against Gram negative pathogens?

How does stress influence cognitive performance? What is the role of selective attention to threatening information in this effect? Could we prevent stress-induced decline of cognitive performance with pharmacological interventions? Could we use resting state theta/beta ratio as a biomarker for cognitive…

Is translocation of nucleases possible via Agrobacterium T4SS and is it efficient enough for mutagenesis?

On 1 April 2020, Marc Broekema defended his thesis 'Cognitive Bias in the Judgment of Business Valuations and Valuators'. The doctoral research was supervised by Prof. J.I. van der Rest.

On May 3rd, Varun de Castro Arrazola succesfully defended his doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Varun on this great result.

The work presented in this thesis addresses the role of the locus coeruleus (LC) - norepinephrine (NE) system in various aspects of human cognition, and the modulation of brain state.

On May 17th, Arthur Crucq succesfully defended his doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Arthur on this great result.

To develop a new generation of brain science (and train scientists) focused on explaining complex real-world behavioural patterns.

On the 12th of October, Fatemeh Tabassi Mofrad successfully defended a doctoral thesis. The Leiden University Centre for Linguistics congratulates Fatemeh on this achievement!

The recently published book 'Tense-Switching in Classical Greek A Cognitive Approach' by Arjan Nijk provides classicists and linguists in general with a complete account of the 'historical present' in Classical Greek.

Knowledge and culture subproject 4:

To investigate the effectiveness of an online self-help programme for people with HIV and depressive symptoms.

Sarah Giest, Assistant Professor at Leiden University, and Ishani Mukherjee researched the topic of 'Behavioural Insights Teams (BITs) and Policy Change: An Exploration of Impact, Location, and Temporality of Policy Advice'.

Sanne Kellij and colleagues systematically reviewed 142 articles, examining evidence for three hypotheses on the relation between victimization and social information processing.

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

We aim to gain a better understanding of the natural disease progression of ALS in order to improve clinical trial design and analysis and to support drug discovery and clinical development of new drugs.

Ontwikkeling van resistentie tegen antibiotica kan optreden als patiënten onnodig of te lang met antibiotica behandeld worden. Diagnostiek waarmee snel een bacteriële infectie vastgesteld kan worden, of de response op antibiotica bepaald kan worden, zijn daarom belangrijk om therapie te optimaliseren…

Researchers at Leiden study group behaviour. One of their findings is that when people make sacrifices for another member of their group, it is probably instinctive. Insights of this kind enable us to better understand and influence the social processes in a neighbourhood or company.

This dissertation investigates Extended Lexical Units (ELUs), elements that are bigger than just one word and which are stored in the Lexicon.

A warm welcome to the Graduate School of Social and Behavioural Sciences at Leiden University.

How to identify patients at risk of developing devastating, metastatic disease and facilitate the development of personalised treatment for prostate cancer patients?

Some MPs are very active, while others are not. The number of proposals and questions that MPs in the Netherlands put forward is determined in part by the level of activity of their fellow committee members rather than by electoral incentive, which is the case in other countries.

Up to 50% of individuals with Parkinson's disease develop cognitive impairment over time; this study explores the use of 'practice effects' on neuropsychological tests as an early predictor of cognitive decline.

Bernard Bernards examines constraints on innovation by focusing on cognitive uncertainty as a personal state that may affect innovative work behavior.

What are the manifestations, antecedents and consequences of the cognitive uncertainty experiences of social care professionals?

The collaboration between Leiden University (Medical Center) and the Autonomous University of Barcelona forms one of the most powerful international alliances for the creation and transmission of knowledge in the field of transfusion medicine.

Programs that aim to reduce symptoms of social anxiety in children generally include multiple components, such as exposure and cognitive restructuring. It is unknown if separate components yield positive intervention effects in children or whether a combination of components is required.

Leiden University researchers and their collaborators report the development of new research frameworks that use day-to-day smartphone behavior gathered from a large sample of healthy people to help understand aging, and how aging alters with epilepsy and stroke. These reports occupy two back-to-back…

Can socioeconomic differences in health behaviour be explained by competing goals and demands in everyday life?

At Leiden University’s Faculty of Social and Behavioural Sciences we keep in touch with our alumni in various ways.

The Faculty of Social and Behavioural Sciences (FSW) aims to play a leading role in gaining insights on current developments in society.

There are five institutes at the Faculty of Social and Behavioural Sciences:

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

In 2021, the National Cyber Security Centre (NCSC) asked Leiden University to conduct a rapid review of best practices and possibilities for follow-up research on the integration of behavioral sciences in security by design methodologies and projects. This academic field is called security by behavioral…

How do humans control their thoughts and actions, and what can high-field brain scanning reveal about the underlying processes?

The research group Organizational & Entrepreneurial Behavior investigates the behavior of individuals and groups who start, work in, or lead organizations, in order to inform organizational practice. By focusing on the behavior of (groups of) employees, entrepreneurs and leaders, the main levels of…

The research question is that unconscious perseverative cognition (UPC) is responsible for a considerable part of cardiovascular (CV) activity that occurs even in the absence of threats and other stressors that one may encounter in one’s daily life.

The Faculty of Social and Behavioural Sciences brings together high-quality research and outstanding teaching in the disciplines of cultural anthropology, education and child studies, political science, psychology, science and technology studies, as well as in multidisciplinary approaches.

This GUTS Special Issue focuses on the dynamic relationship between neurobiological development and social experiences in shaping young people's engagement and contributions to society. It explores how young individuals grow up in an increasingly complex world and how various factors – such as family…

How do cognitive, motivational, and affective processes interact to select actions?

A key challenge in neuroscience is understanding how neurons in hundreds of interconnected brain regions integrate sensory inputs with previous expectations to initiate movements and make decisions.

The master's specialisation Health and Medical Psychology consists of three main parts: the mandatory and elective courses, a thesis and an internship.

Cancer is the leading cause of death in the Netherlands, and, with over 100 different types of cancer, it’s not a simple disease. Today, skin, breast, lung, prostate and colon cancer are the most diagnosed forms. Therefore, the discovery and development of new drugs has the ability to significantly…