We consider the propagation of electrical signals through nerve fibres.

Didactics

How can teachers be motivated by their students’ data in making stepwise changes to their teaching practices?

This thesis develops a method for direction dependent calibration of the ionosphere in radio interferometric data.

The thesis is about the study of shell evolution of the Hydrocenidae of the genus Georissa. This thesis started with a general overview on the evolutionary process of animals due to ecological changes.

The research specialisation offers you the opportunity to spend two full years on training in applied mathematics to become an independent scientist with a strong theoretical basis.

Promotores: P. Stevenhagen, L. van Geemen Co-promotor: R.M. van Luijk

Chemical tools to monitor drug-target engagement of endogenously expressed protein kinases are highly desirable for preclinical target validation in drug discovery. Here, we describe a chemical genetics strategy to selectively study target engagement of endogenous kinases.

Collaborative linguistic research on indigenous languages of Ecuador: description, documentation & materials

This study examined the effects of a classroom-focused intervention on different domains of early literacy. The intervention consisted of shared e-book reading combined with a print referencing technique done via a SMART board. The specific goal of the study was to examine whether children could be…

In this thesis, we address two problems concerning the tautological rings of the moduli space of curves.

In this thesis, topics relating to the optimization of high-throughput pipelines used for imaging are discussed. In particular, different levels of implementation, i.e., conceptual, software, and hardware, are discussed and the thesis outlines how advances on each level need to be made to make gains…

The subject areas covered encompass functional genomics, signal transduction, cellular differentiation, development, host-microbe interactions and animal behaviour.

This is an Erasmus+ International Credit Mobility project of Leiden University Medical Center with Boston Children’s Hospital in the USA.

In this research group, led by Dr. Joost Beltman, the aim is to employ mathematical and computational dynamical modelling approaches in order to quantitatively and mechanistically understand the dynamical behaviour and regulation of intracellular networks of genes, proteins and metabolites as well as…

Managing Diversity: Supervising Functions in Managing Colonial Workplaces

When to launch a next-generation product in a competitive market and how much capacity should be allocated to it

1. What is the exact role of PIN proteins in PAT? 2. How is PIN polarity established, and how is it modulated by AGC kinase-mediated phosphorylation? 3. What is the role of the AGC kinase, as modulators of PAT, in translating environmental signals, such as gravity, light or mechanical stress, to plant…

The central aim is to systematically study differences in gendered crime patterns in the records of different types of courts in various Dutch cities in the early modern period.

This Research project is funded by the 7th European Community Framework Programme, with additional funds from NWO Aspasia grant, and in collaboration with University of California, Berkeley.

Brain development in children with an extra X chromosome as compared to children with autism: evidence from MRI

This paper provides an initial answer to the question regarding eco-labels: ‘How can we make the development of eco-labels more structured and transparent?’

Abrupt Climate Change and Cultural Transformation

This thesis presents a detailed description of the phonology, the tone system and the grammar of Liko, a Bantu language spoken by about 70,000 people in the northeastern part of the Democratic Republic of the Congo. It provides numerous examples.

This collection of seventeen essays takes its inspiration from the scholarly achievements of the Dutch historian Jan Lucassen. They reflect a central theme in his research: the history of labor.

Do recent developments in the European security architecture signal the end of multilateral cooperation, or the beginning of a new era with emerging forms of international security collaboration?

Whilst government’s ability to design ‘context-specific’ regional innovation policy is generally assumed to depend on the region’s decision-making power, the aim of this study is to investigate how regional government matters. In order to open up the black box of policy design, the study develops a…

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

This thesis investigates the application of deep learning techniques in image analysis across various domains, focusing on four main themes: feature extraction, classification, segmentation, and integration, demonstrating the transformative potential of these technologies.

In this article, Madeleine O. Hosli and Wen Pan examine how intergovernmental dynamics shaped the European Stability Mechanism, using Liberal Intergovernmentalism to assess negotiation phases, the influence of major member states, and which theoretical assumptions hold or need qualification.

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

The research of the Applied Mathematics cluster is concerned with such diverse topics as dynamical systems, representation theory, differential equations and pattern recognition.

As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.

Source: Mediators Inflamm (2014)

This dissertation explores matters of collectivity, drawing from the experience of working with the Amsterdam-based collective Hackers & Designers (H&D).

Promotor: Prof.dr. F. den Hollander

Patterned detectors are an existing technology that can be found in almost all color cameras.

The central inquiry of this thesis revolves around how ontology can adequately accommodate the existence of necessary physical relations. Initially, the thesis demonstrates the imperative acknowledgment of necessary physical relations by showcasing the failure of Neo-Humean theories.

Research and design are two activities that are becoming increasingly important in the Dutch subjects O&O (‘research and design’) and NLT ('nature, life and technology’). The dissertation of Tessa Vossen (ICLON and Faculty of Science) indicates that teachers and students understand the importance of…

This dissertation investigates ikat from the eastern Indonesian islands from a uniquely technical perspective, including design analysis of asymmetry and microscopy.

Streptomyces are prolific producers of enzymes and secondary metabolites, including more than 50% of all clinical antibiotics. This makes them highly attractive for medical, biotechnological, and industrial purposes.

Paisaje, cerámicas e interacciones

This dissertation focuses on teacher professional learning and collaboration in secondary schools.

On the 29th of June, Martin Kohlberger successfully defended a doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Martin on this achievement!

Accurately recognising others’ emotions is a fundamental social skill, relevant for navigating the social world from early childhood. Children’s ability to do represents a milestone in their socioemotional development and is associated with a number of important psychosocial outcomes. Many individual…

During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.