In this thesis, we examine various systems through the lens of several numerical methods.

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

In this thesis we will explore the use of fuzzy systems theory for applications in bioinformatics.

In 2018, the number of mobile phone users will reach about 4.9 billion. Assuming an average of 5 photos taken per day using the built-in cameras would result in about 9 trillion photos annually.

On Friday 24 March, Prof. Amanda Perry-Kessaris (Kent Law School) will deliver the monthly Leiden Socio-Legal Lecture.

On January 29th, the first annual event of the SUPER MoRRI project will be held in the Lipsius building in Leiden and will be thematically organized around engaging the public with research and innovation. Registration is free; hope to see you there!

Lecture, Tuesday Talks: Science Insights

In this thesis, several aspects of software debugging from automated crash reproduction to bug report analysis and use of contracts have been studied.

To increase clinical success rate of drugs, a better understanding of drug action mechanism and disease dynamics is required. Metabolomics, which studies small molecules involved in biochemical processes in organisms, has shown to be a useful tool for this better understanding.

The first of the two volumes of this co-authored study has just been published by Metzler. The study explores the history of the concept ‘barbarism’ from the 18th century to the present and illuminates its foundational role in modern European and Western identity.

The Netherlands Organisation for Scientific Research has awarded Leiden astronomer Giovanni Rosotti a Veni grant for research into very young exoplanets. This grant offers young researchers the possibility to develop their innovative ideas for a period of three or four years.

In deep reinforcement learning, searching and learning techniques are two important components. They can be used independently and in combination to deal with different problems in AI, and have achieved impressive results in game playing and robotics. These results have inspired research into artificial…

On this page, you can find a short description of the participating researchers.

Despite being the second largest transmembrane protein family after GPCRs, the SLC superfamily has only gained significant attention in early drug development over the past decade.

Human vocal communication and music perception represent advanced cognitive skills, seemingly innate and universal. These faculties encompass a range of perceptual and cognitive abilities. Cross-species research sheds light on the origins of musicality by investigating whether these traits are shared…

As a contribution to the changing legislation and evolving societal attitudes concerning environmental issues, this project aims to enhance and manipulate the plants’ own natural defense mechanisms against western flower thrips (WFT).

Neurodegenerative diseases pose a large medical and societal challenge. The etiology of these diseases is still poorly understood, which makes drug discovery for these diseases difficult.

Galaxies in the early universe are shrouded in a kind of mist: a cloud of hydrogen. With galaxies in the later universe this mist has disappeared. Astronomer Jorryt Matthee has made the first images of this dissipating mist. PhD defence 19 September.

This special issue of the peer-reviewed journal Amsterdamer Beiträge zur älteren Germanistik (Brill, 2021) brings together articles that explore new digital ways of analyzing and annotating Old English vocabulary.

How do urban residents in Brazil and the Netherlands (The Hague and Leiden) perceive the cultural benefits of urban forests? How are these benefits spatially distributed across cities? How do socio-demographic factors shape these perceptions, and do these differences vary between countries?

Currently the focus of the project is the development of a tool that utilizes dimensionality reduction techniques in order to analyze and interpret the lexical and phonological variation between different sign languages. Additionally, the application of deep learning techniques for the extraction of…

Until the 1990s, the only known planets were those in our Solar System. Three decades later, several thousand exoplanets have been discovered orbiting stars other than the Sun, and substantial efforts have been made to explore these strange new worlds through spectroscopic analyses of their atmosphe…

In the search for sustainable energy solutions, the idea of artificial photosynthesis has been proposed as an approach with which to use water and sunlight to produce hydrogen.

In the era of big data, extracting insights from complex datasets is a key challenge. This thesis demonstrates the superiority of graph-based methods over traditional clustering (e.g., k-means, DBSCAN) and outlier detection for analyzing high-dimensional and noisy data.

A project to explore the configuration of different types of settlement and its role in the evolution of landscape, both in pre-Roman times and in the so-called Colonial landscape. We used several techniques of field survey, pottery classification and other non-invasive approaches to the archaeological…

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

This thesis investigates reactive interfaces in surface science across three domains: heterogeneous catalysis, environmental nanoplastics, and two-dimensional materials.

Is our musicality unique? To find out, the Bird Singalong Project brings together singing parrots from all over the world. Do you have a parrot that sings or whistles along to songs and would you like to help us? Sing up now!

The center studies the many ways in which issues of law and justice are dealt with in art and literature with a focus on liminal issues and cases. These are issues and cases where law comes to the limits of what it is capable of dealing with and art and literature explore the implications of what is…

Since 2005 Leiden fieldschools have maintained local collaborations with archaeologists on Martinique carrying out surveys and excavations.

How do lipases in Mycobacterium tuberculosis help the bacteria survive, and can we target them to create new antibiotics?

Learning analytics tracks students’ online learning activities in order to support their learning. But what if most of their learning takes place offline, out of sight of digital eyes?

The research project of Yannis Patoukas proposes to explore the different intersections between experimental rock music of the 1960s and 1970s and electroacoustic music, with regard to studio practices and production techniques and their creative possibilities.

Microscopic insight on lipid-based nanomedicine in vivo remains limited to the perception of the knowledge that could be obtained: if we interpret only what we see, then we only believe to know. Although believing to know encapsulates an undefined amount of uncertainty in the exploration of lipid-based…

This summer, Leiden, The Hague, Noordwijk and Delft will be hosting the ‘Sizzling Summer of Space’. To tie in with the international Space Studies Programme, all kinds of activities on space exploration are being organised, from a film evening to a Science Café and an exhibition of satellites to the…

SRON Netherlands Institute for Space Research is moving. In 2021, the Utrecht branch will settle in South-Holland. Pieter Dieleman is group leader at SRON. He tells why the upcoming move is such a good idea: ‘SRON is a connecting factor between Delft and Leiden.’

For the first time, astronomers have managed to take a photo of a supermassive black hole and its shadow. They used the Event Horizon Telescope (EHT), a worldwide network of eight radio telescopes that together form a virtual telescope the size of the earth. The news was presented in six press conferences…

By adding their signature to the collaboration agreement on 31 May, Leiden University, TU Delft, space research institute SRON and NWO confirmed the move of SRON from Utrecht to South Holland. From 2021, the headquarters of the space research institute will be located on the Campus of Leiden Univ…

The second and final volume of this co-authored study has just been published by J.B. Metzler. This second monograph explores the history of the concept of barbarism in the twentieth and twenty-first centuries.

Barbarism: from the 18th century to the present.