405 search results for “extracellular maria” in the Public website
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NWO Internationalisation in the Humanities grant for dr. Maria Boletsi
The project aims to explore the history of the concept “barbarism” in Europe from the 18th century to the present. Responding to the contemporary popularity of the term “barbarism” in political rhetoric and the media, and the lack of reflection on the implications and legitimacy of its use, the project…
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Maria Fraskou at conference hosted by Stanford University
On March 31st – April 1st, the Association for the Study of Law, Culture and the Humanities (ASLHC) will hold its twentieth annual conference at Stanford Law School.
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Structure-kinetics relationships of Capadenoson derivatives as adenosine A1 receptor agonists
Source: Eur J Med Chem, Volume 101, pp. 681-91 (2015)
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Prediction of spatial-temporal brain drug distribution with a novel mathematical model
A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.
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PhD candidate Maria Vasile presents her research in the talk show Weekly Seeds
Maria discusses her case studies with a broader public
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Maria Fraskou presents a paper at the International Conference "Europe as a Global Actor"
The Centro de Estudos Internacionais at Instituto Universitário de Lisboa (ISCTE-IUL) will host the
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Maria Pichou selected as Judge for the International Criminal Court Moot Court Competition
Maria Pichou is selected to act as a judge for the 2019 International Criminal Court Moot Court Competition (ICCMCC). Dr. Maria Pichou is Assistant Professor at Leiden University College The Hague.
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stars to reveal the secrets of the darkness: ERC Consolidator for Elena Maria Rossi
The centre of our Galaxy is so dark and dense that it is almost impossible to observe what is inside. By catching the rare hypervelocity stars that are ejected from it, Elena Maria Rossi aims to unveil the mysterious environment around the supermassive black hole inside. But she’ll also be solving another…
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Cell adhesion signaling: dynamics, migration, and metastasis
Cell adhesion signaling
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Mechanisms and consequences of horizontal gene transfer in cell wall-deficient cells of Kitasatospora viridifaciens
The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…
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Biodiesel production using blue-green cyanobacterium Synechococcus elongatus PCC 7942
Promotores: Prof.dr. C.A.M.J.J. van den Hondel, Prof.dr. V. Meyer (Technische Universität Berlin)
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Cancer Drug Target Discovery
We focus on a better understanding of the mechanisms of cancer drug resistance and metastasis.
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Inverse Agonism and Constitutive Activity
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GRIPonMASH
GRIPonMASH will address the unmet public health need of reducing disease burden and comorbidities associated with Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD).
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Microfluidic 3D cell culture for high throughput screening
There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.
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Controlling growth and morphogenesis of the industrial enzyme producer Streptomyces lividans
Promotor: Prof.dr. G.P. van Wezel, Co-Promotor: E. Vijgenboom
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Noonan and LEOPARD syndrome in zebrafish: molecular mechanisms and cardiac development
Promotor: Prof.dr. J. den Hertog
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Computational modeling of angiogenesis: from matrix invasion to lumen formation
Promotor: Roeland M.H. Merks
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Human skin equivalents for atopic dermatitis: investigating the role of filaggrin in the skin barrier
Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: Dr. A. El Ghalbzouri
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The Function of Toll-like receptor 2 in Infection and Inflammation
The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.
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Ecological functions and environmental fate of exopolymers of Acidobacteria
Acidobacteria is a widely distributed phylum but their functional roles in ecosystem processes are still largely elusive.
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Predicting early Alzheimer's disease stage in human
A new research line is the development of liquid biopsy fingerprints to predict early Alzheimer’s disease (AD) stage in human in readily accessible body fluids in human (in collaboration with: Dr. Geert-Jan Groeneveld, CHDR; Prof. Elga de Vries, Free University Medical Center; and others).
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De la gloria al olvido
Estudio arqueológico de la primera ciudad española en la Tierra Firme de América: Santa María de la Antigua del Darién
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Mayan languages in contact: Awakateko and K’iche’ in Guatemala
This project focuses on two Mayan languages in contact: Awakateko and K’iche’. With the aim to create a database to be accessible to researchers, students, and indigenous activists interested in Mayan languages, this project will train Mayan speakers on transcription, translation, and analysis of…
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ERC Starting Grant for Roxanne Kieltyka: stem cells in gels
Chemist Roxanne Kieltyka has received an ERC Starting Grant of 2 million euros. In her lab, she creates gels that mimic the instructive material that supports cells in our body. With the grant, she aims to make these gels stiff and tough, and to create a bio-printed miniature heart ventricle.
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TGF-β and extracellular vesicles in the tumor microenvironment
PhD defence
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Role of integrin adhesions in cellular mechanotransduction
Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen
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Functions of P38 and ERK kinases in zebrafish early development
Promotor: Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar
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Whole-cell biosensor for label-free detection of GPCR-mediated drug responses in personal cell lines
Source: Biosens Bioelectron, Volume 74, pp. 233-42 (2015)
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Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and
Source: Mol Psychiatry (2015)
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Respiratory-chain enzymes
Ever since the FDA approved the drug bedaquiline, which interferes with the bioenergetics of Mycobacterium tuberculosis by inhibiting the activity the F0F1-ATP synthase, respiratory-chain enzymes have been an active target space for the discovery of new antibiotics. To aid in this pursuit, we aim to…
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Cancer Drug Target Discovery
In this research group, headed by Prof. Erik Danen, the aim is to unravel cellular signaling mechanisms in normal and diseased cells, with a long-standing interest in cell adhesion signaling. In complex multicellular organisms such as ourselves, a division of labor emerges where different tissues and…
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Multi-Biomarker Pharmacokinetic-Pharmacodynamic Relationships of Central Nervous Systems Active Dopaminergic Drugs
Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.
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English language check
Publishing about your research is a key aspect of your career as a researcher; the majority of research publications are written in English. When applying for research funding, too, it is very important to ensure that your application is written in clear, accessible English. Maria Sherwood-Smith, Academic…
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(Un)timely Crises: Chronotopes and Critique
Un)timely Crises explores how ‘crisis’—as a narrative, concept, grammar, and experience—structures time and space. This collectively written volume extends Bakhtin’s ‘chronotope’ to challenge mobilizations of crisis within neoliberal governmentality. The book explores how contemporary crises can trigger…
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Diversity
Among Leiden’s Firsts was Hajjah Maria Ulfah Soebadio Sastrosatomo. In 1933, she was the first Indonesian woman student to earn a law degree.
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Kazimierz Twardowski: A Grammar for Philosophy
Kazimierz Twardowski (1866-1938) is the founder of the Lvov-Warsaw School with its strong tradition in logic and its scientific approach to philosophy. Twardowski’s unique way of doing philosophy, his method, is of central importance for understanding his impact as a teacher.
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Crisis and Critique Network
This network brings together scholars whose work explores how contemporary frameworks of crisis produce experiences of the present, rehash or disrupt established narratives of the past, and broker specific outlooks on the future. We collaborate in studying these crisis-scapes and exploring how they…
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Dissemination
This section features online articles by or about the team members of the Food Citizens? project.
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Cuerpos ilegales. Sujeto, poder y escritura en América Latina
Corporeality, intimately bound to the notion of space, to the diffuse border that connects, entangles, and fuses an inside and an outside, is understood in this book as a space which puts the individual at stake as a war machine that, in its fight for a form of life, redefines political territories.
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Barbarian: Explorations of a Western Concept in Μodern Theory, Literature and the Arts. Vol. 1: From the Enlightenment to the Turn of the Twentieth
Barbarism: from the 18th century to the present.
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Legitimiteit en rechtswaarborgen bij gesloten plaatsing van kinderen
On 7 March 2019, Maria de Jong-de Kruijf defended her thesis 'Legitimiteit en rechtswaarborgen bij gesloten plaatsing van kinderen'. The doctoral research was supervised by Prof. mr. M.R. Bruning en Prof. mr. T. Liefaard.
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Barbarian: Explorations of a Western Concept in Theory, Literature and the Arts Vol. 1
The first of the two volumes of this co-authored study has just been published by Metzler. The study explores the history of the concept ‘barbarism’ from the 18th century to the present and illuminates its foundational role in modern European and Western identity.
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Humanities the movie
The Faculty of Humanities consist of various academic fields. What is the common ground of all these different academics and students? They tell their story and why it matters in today’s world in 'We are Humanities'.
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Pharmacometabolomics; prediction of system-wide multi-biomarker drug response
The lack of success of new CNS drugs in clinical development is in part due to the complexity of the CNS, unexpected side effects, difficulties for drugs to penetrate the brain, but also by the lack of biomarkers.
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Metabolomics and Analytics Centre
The ambition of the Metabolomics and Analytics Centre led by Thomas Hankemeier is to develop innovative analytical strategies for metabolomics-driven health monitoring and systems biology studies. Understanding the intricate balance between health, disease and adaptation to challenges relies on the…
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Noisy brains, noisy choices? Exploring age-related changes in neural circuits for decision-making
Brain activity changes as people age, which can lead to cognitive decline. By measuring and comparing brain data from mice and humans, the researcher will investigate how the brain’s noise levels change with age and affect choice behavior.
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Semi-artificial photosynthesis
Artificial photosynthesis aims to produce fuels from solar energy using chemical processes. In semi-artificial photosynthesis, a hybrid approach is taken using both chemical and biotechnology components. We are developing hybrid systems, coupling light-harvesting nanoparticles to redox-enzymes (oxidoreductases)…
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Publications
Our subscribers have written several publications about international security issues.
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Specters of Cavafy
Haunting the future through poetry