Ever since the FDA approved the drug bedaquiline, which interferes with the bioenergetics of Mycobacterium tuberculosis by inhibiting the activity the F0F1-ATP synthase, respiratory-chain enzymes have been an active target space for the discovery of new antibiotics. To aid in this pursuit, we aim to…

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Research in the Lars Jeuken group focusses on redox-active proteins and membranes enzymes, aiming to understand bacterial respiration at the molecular level for the development of antimicrobials and semi-artificial photo-synthetic cells.

This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.

Animal Sciences’ contributions to the Host-Microbe Interactions research theme focus on the interaction of animal hosts with pathogenic microbes but also the beneficial role of the gut microbiome.

The aim of this thesis was to study phage infection in Streptomyces, focused on cell wall-deficient cells. Bacteriophages (or phages in short) attach to the cell wall of bacteria after which they replicate and lyse the host cell.

Control of infectious diseases poses continuous challenges for human health.

How can we enhance inspiration in metric modal improvisation and subsequently, in modal composition?

An overview of new research project: Politeness in Arabic Papyrus Letters

Sociopragmatics is a rapidly growing field and this is the first ever handbook dedicated to this exciting area of study.

Researchers at Leiden University Medical Center (LUMC) and Radboud university medical center have been given the green light to deliberately infect volunteers with malaria in order to test a highly promising vaccine on them.

How do mycobacteria subvert the defenses of host immune cells?

The current resurgence of whooping cough is alarming, and improved pertussis vaccines are thought to offer a solution. Outer membrane vesicle vaccines (omvPV) are potential vaccine candidates, but omvPV-induced humoral responses have not yet been characterized in detail.

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

Leiden University and Leiden University Medical Center have joined the Netherlands Centre for One Health (NCOH), further strengthening the academic network in which such problems as antimicrobial resistance are studied.

Health workers have always sought ways to fight disease in vulnerable groups in the population. It is now clear that such research also benefits more prosperous countries. African worm infections and innovative thermometers have shown Leiden researchers how to fight diseases of affluence and keep health…

How can efficient chemical synthesis and clinical microbiology be combined to identify new antibiotics against Clostridioides difficile infections?

Source: PLoS ONE, Volume 10, Issue 3 (2015)

Tuberculosis is a major global health problem caused by the Mycobacterium tuberculosis complex, claiming more than a million lives annually.

Promotor: C.A.M.J.J. van den Hondel, Co-promotor: Sandra de Weert

In STAYAHEAD data-intensive approaches are being developed to ”decode the human immunome” with a focus on a global vaccine strategy. They have developed a rapid mass spectrometric test to analyse in real-time large numbers of variants of SARS-CoV-2 and the host immune response, and use these data to…

The outbreaks of AIDS and COVID-19 showed clearly how infectious viruses can influence people’s lives. Investigating the changes in the host metabolism may provide a paradigm shift to consider immune-metabolic interactions as therapeutic targets.

The Examination Board of the Honours Academy determines whether the student meets the requirements of the relevant honours programme and handles requests for exceptions.

A research into how people eat and drink during their daily routines, and the circumstances under which these activities take place.

By drawing on the personal experiences of contributors based in different institutions and countries, the articles in this special issue provide a fairly broad overview of ethics practices and concerns in different localities (though not globally, as we had originally hoped), showing, as one student…

When combined and used by specific people located in time and place, words can express something more than, different from, or even the opposite of their dictionary meanings.

Semantics and pragmatics are united in the study of linguistic meaning.

This research cluster centres on regional, national, and global intersections between a variety of artistic and cultural expressions and their role in society from 1800 onwards.

How do social and political developments influence the process of meaning-making in different parts of the world? Why is a particular discourse interpreted in numerous ways depending on the context it is produced and propagated? And how are culture, politics, history, and language intertwined?

From corpus pragmatics and metapragmatics to accountability and intentions, and from conversational structure and im/politeness to the role of emotions in utterance interpretation, the short articles collected here represent not just the wide scope of Michael's own work but also a snapshot of the field,…

Antimicrobial resistance (AMR) is the phenomenon that pathogens become insensitive to the antibiotics that we use against them. A growing number of pathogens is becoming resistant, with methicillin-resistant S. aureus (MRSA) as the most famous example. But while the threat of AMR represents a slow-moving…

The Translational Immuno-Pharmacology group works on translating the efficacy of anti-infective therapy from preclinical (e.g. in vivo) to clinical, and is led by Rob van Wijk. Infectious diseases, such as tuberculosis, are in constant need of new therapies that work better, faster, and with less risk…

Uncover novel antimicrobials with prospective health benefits for sea turtles.

More than 1.3 million people worldwide die of tuberculosis (TB) each year, making research on its prevention and control essential. Researchers from various disciplines in Leiden are studying TB. A symposium on 24 March will highlight different activities in the hope of boosting nationwide collabora…

Macrophages – the front line of our immune system – protect us from infections. But in the case of the tuberculosis bacteria, this often goes wrong. The group of Annemarie Meijer from the Leiden Institute of Biology has now discovered that macrophages in zebrafish are better able to eliminate tuberculosis…

For a full overview of the publications of the Translational Immuno-Pharmacology group, visit the Google Scholar page.

Human and animal cells are very complex: very different chemical processes are going on at the same time, but they are separated from each other because the cells are divided in compartments. These compartments may also have a profound effect on the potential efficacy of therapeutics, because the drug…

Parasitic worms and stomach bacteria suppress immune reactions such as allergic responses. Parasitologist Hermelijn Smits and lung specialist Christian Taube from the LUMC are trying to learn from these micro-organisms.