Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh

On a structural level, the properties featured by a majority of mechanical metamaterials can be ascribed to the finite number of soft internal degrees-of freedom allowing for low-energy deformations.

Benjamin Fogarty-Valenzuela published the article 'Pedagogies of Prohibition: Time, Education, and the War on Drugs in Rio de Janeiro’s Zona Norte' in Cultural Anthropology 37. The article’s three sections focus on three forms of temporal control—busyness, punctuality, and rhythm—and each demonstrates…

Research and design are becoming more and more important in international science education. In The Netherlands, two recently introduced subjects focus on research and design activities in the classroom: O&O (research and design) and NLT (nature, life and technology). This research aims to look at what…

Can we develop a generic method for Quan/Qual analysis of small molecule drugs, their metabolites and endogenous metabolites in (pre-)clinical samples?

Source: ChemMedChem (2015)

During the course of drug discovery translational steps are made.

This thesis describes the importance of being able to control the selectivity of potential drug candidates.

Another research line is the development of a spatial CNS drug distribution model, by ultimately including the 3-dimensional anatomical organization of the CNS.

Heart failure is a major health care problem with high mortality.

This thesis investigates how non-genetic factors, such as inflammation and concomitant medication, impact hepatic drug metabolism and subsequent drug metabolizing phenotype predictions.

The project seeks to develop an eco-design framework for single-use medical devices and packaging

This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.

Data analysis with Python and R are rapidly becoming essential skills for modern scientists. Therefore, we are offering courses to develop your scientific computing skills. Those courses are optional for LACDR PhD candidates.

Promotor: A. Kros

Human and animal cells are very complex: very different chemical processes are going on at the same time, but they are separated from each other because the cells are divided in compartments. These compartments may also have a profound effect on the potential efficacy of therapeutics, because the drug…

Welcome and great to see you are interested in Designing Your Life education! Whether you are a student or educator, this website has everything you need to get started.

This research intends to study the why, what, how and the possible outcome of internationalisation in higher education institutions of fine art and design.

Patterned detectors are an existing technology that can be found in almost all color cameras.

Procedural administrative law in a constitutional comparative law perspective

In the first part of this thesis we study the geometry of folding patterns.

Developing new drugs is a difficult process. With the aid of artificial intelligence, Pharmaceutical scientist Xuhan Liu has developed methods that can help make drug design cheaper and faster. PhD defence on 15 February.

Activity-based protein profiling (ABPP, also termed chemical proteomics), is one of the pillars of chemical biology, and at LED3 we have taken it to the next level. ABPP allows the assessment of protein function in live cells and tissues, which means that the activity of a complete protein family can…

In 2021, the National Cyber Security Centre (NCSC) asked Leiden University to conduct a rapid review of best practices and possibilities for follow-up research on the integration of behavioral sciences in security by design methodologies and projects. This academic field is called security by behavioral…

Promotor: A.P. IJzerman Co-promotor: L.H. Heitman

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

Promotores: Prof.dr. H. S. Overkleeft, Prof.dr. G. A. van der Marel

Analysis of drug adversity

In this article, Marieke Liem and Kim Moeller revisit Goldstein’s framework on the drugs-violence nexus

The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.

High throughput microscopy

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: Dr. L.H. Heitman

This project’s aim is to critically assess current homicide data sources in order to develop a proposal for long-term EU-level monitoring of DRH.

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

Desinging Your Life helps students at Leiden University to design their life path and face the future with confidence. On this website, you find all you need to know about your Designing Your Life opportunities in Leiden.

Source: Nature Biotechnology, Volume 2014, Issue June (2014)

What dose of medicine do you give a child? That depends to a large extent on how quickly their kidneys remove the drug from the blood. For ethical reasons it is impossible to measure this directly in little patients. PhD candidate Sinziana Cristea combined different types of modelling and lots of data…

The lack of success of new CNS drugs in clinical development is in part due to the complexity of the CNS, unexpected side effects, difficulties for drugs to penetrate the brain, but also by the lack of biomarkers.

The studies reported in this thesis were situated in the context of an innovation of Dutch secondary school biology curricula. As in any innovation, the practical knowledge of teachers determine the outcomes through the decisions they make while planning and teaching their lessons. The aim of the studies…

Promotores: C.A.J. Knibbe; J.N. van den Anker, Co-promotores: H.P.A. van Dongen; B. van Ramshorst

From descriptive to physiological models that can predict oral absorption and elimination of CYP3A substrates across the pediatric age range.

Promotor: A.P.IJzerman Co-promotor: A. Bender

Promotor: B. van de Water

He’s a fast and animated speaker, which is only logical because Gerard van Westen is driving an express train. His destination? A virtual human, consisting of algorithms that predict what an administered substance will do in the body. The train is already a long way down the line and the pharmaceutical…

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.