n this PhD thesis, the recombination of different atomic lattices in stacked 2D materials such as twisted bilayer graphene is studied. Using the different possibilities of Low-Energy Electron Microscopy (LEEM), the domain forming between the two atomic layers with small differences is studied.

The Physics and Quantum Matter and Optics specialisation is one of the two programmes Leiden offers in experimental physics. The programme can be tailored to individual needs and interests.

You can copy and print within the University using multi-function printers (MFPs). For this you will need a LU-Card. Want to know how to add a printer? Or print securely? As a student, you can find more information on the student website. As a staff member, you can visit the staff website.

The chemical industry must continue to innovate for a more sustainable, healthier society. The reseachers from the Leiden Institute of Chemistry (LIC) contribute by applying their knowledge to themes such as sustainability, energy and health.

High throughput microscopy

In this thesis, we develop a novel technique called Optical Near-field Electron Microscopy (ONEM), which aims to combine the advantages of both optical and electron microscopy: the high resolution of electron microscopy and the low sample damage of optical microscopy.

The dissertation describes TEM experiments on heterogeneous catalysts.

The purpose of this study was to investigate the formation and growth kinetics of complexes between proteins and oppositely charged polyelectrolytes.

Making the most vibration-free, cryogenic scanning tunneling microscope in the world. A bold mission, but one that PhD candidate Irene Battisti successfully executed together with the Fine Mechanical Department. The new microscope might shed light on how unconventional superconductivity works. PhD Defence…

Serge Rombouts is a physicist whose PhD thesis was about functional MRI (fMRI). This visualises activity in regions of the brain. The appealing images of glowing brain regions that emerge from the computer are the result of calculations. According to Rombouts, this isn’t proper artificial intelligence.…

The Netherlands Organisation for Scientific Research (NWO) has made a subsidy of 17 million euros available to further develop a Netherlands network for electron microscopy (NEMI). The network comprises five UMCs and eight universities, with Utrecht in the coordinating role. From Leiden, the Institute…

To be able to measure small forces or small deviations from Boltzmann, the external vibrations at the resonance frequency must be very low. To achieve this, we have developed a very soft vibration isolation system and combine it with several other measures to reduce vibrations in our dilution refrigerators.…

Electrolysis is a technique that can be used to convert CO2 into fuels and other useful products. To do this efficiently and on a large scale, however, we need to understand exactly how electrolysis works. Professor Marc Koper is an expert in this field.

Graphene has held a great promise for applications since it was first isolated in 2004. But we still don’t use it in our large-scale technology, because we have no way of producing graphene on an industrial scale. Leiden physicists have now visualized for the first time how atoms behave in between graphene…

Leiden University, together with Utrecht University, the LUMC and 10 other Dutch universities and institutes, has been awarded a grant of more than €30 million in the NWO call Roadmap Large-scale Scientific Infrastructure (GWI).

In the course 'From Ceramics to Plastics: The Mediterranean in 12 objects' students were taught to work with 3D scanning technologies. One of the underlying reasons to introduce students to this technology was to teach them to reproduce objects. ‘More and more archaeological information is stored in…

Physicist Milan Allan will build an instrument that will bring superconductivity research further. He has been awarded an ERC Consolidator Grant of 2 million euros over the next five years. With his PairNoise programme he aims to detect paired electrons as they occur just above the temperature at which…

The master’s specialisation Research in Physics, Quantum Matter and Optics at Leiden University offers a thorough experience on the front line of physics research with a practical training of communicative and computer skills. The programme focuses on Condensed Matter problems, such as Molecular Electronics,…

Promotor: B. van de Water

Promotor: B. van de Water

In ancient times, the desert in the Udhruh region in Jordan was transformed into a green oasis. An intricate network of underground water channels was part of an ancient system of water management, storing water and preventing loss through evaporation. Archaeologist Mark Driessen found a new way to…

In this thesis the combinatorial use of bioorthogonal labelling and Electron Microscopy (EM)-based imaging techniques is explored to enable observations of specific molecular targets in their ultrastructural context within the cell.

Chinese and Leiden scientists came together in Leiden to study the intricacies of modern visual techniques.

Advanced microscopy to understand life and fight disease: that’s the goal of the new NL-BioImaging network that will develop and integrate state-of-the-art microscopy technologies and services. Researchers from all Dutch universities, including Leiden University and the Leiden University Medical Centre,…

The research in this thesis is focused on tomographic reconstruction based on two imaging modalities in electron microscopy.

The winner of the Paul & Tatiana Ehrenfest physics thesis prize 2020 is Koen Bastiaans. He carried out his PhD research in the group of Milan Allan and defended his thesis in December 2019 cum laude at Leiden University.

Molecular materials have been a subject of interest in fundamental research and applications for decades, and have been studied as bulk crystals, (thin) films and as individual molecules, due to the large variety in their properties. This dissertation explores pentacene crystals near the two-dimensional…

Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel

Microscopic insight on lipid-based nanomedicine in vivo remains limited to the perception of the knowledge that could be obtained: if we interpret only what we see, then we only believe to know. Although believing to know encapsulates an undefined amount of uncertainty in the exploration of lipid-based…

Due to the corona crisis, they had to switch to online education halfway during their course: associate professor Marcel Schaaf and PhD candidate Michiel Hooykaas of the Institute of Biology Leiden talk about digital practicals, online lectures and their biggest obstacle: exams.

Leiden Physics Poster

‘Microscopy is by far the least understood, most inefficiently operated, and the most abused of all laboratory instruments,’ reads the quote on the office wall of microscopy unit supporters Joost Willemse en Gerda Lamers. It describes exactly why the two developed the microscopy course for starting…

In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.

Core Facilities are shared resources that provide access to instruments, technologies and services to researchers across the Institute of Biology. They are staffed by scientists with vast experience in their field, ensuring that all researchers can count not only on the latest available technology…

Bacteria are everywhere. They are the most abundant organisms on earth and impact all aspects of our lives. They determine our health and shape our environment. Ariane Briegel, professor of Ultrastructural Biology, freezes bacteria super fast to gain a true-to-nature image of the internal and external…

On February 2nd the book Beelden zonder weerga appears, written by professor in science history Dirk van Delft and biochemist Ton van Helvoort. They describe the rich history of electron microscopy, which comes to a conclusion in the final chapter with the current state-of-the-art ESCHER microscope…

This dissertation revolves around the design and implementation of novel instrumentation and related measurement techniques, at the single molecule level, for use in biophysical research. Chapter 1 presents an introduction to the field of fluorescence-based single molecule measurements. In particular,…

Neuroscientist Anne Hafkemeijer is able to distinguish two different forms of dementia using advanced imaging techniques. This is the first step towards early recognition of dementia in patients on the basis of brain networks. PhD defence 26 May.

Bacteria have the ability to alter their morphology in order to adapt to changing environments.

This doctoral thesis is an effort to understand how lipid phase-separation induced by diacylglycerol analogues in lipid-based nanoparticles affects their in vivo behavior, leading to specific nanoparticle-protein communications and selective cell targeting.

The High Troughput Microscopy Dutch Flagship Node that includes the Leiden Cell Observatory Screening platform is now officially ratified as a Euro-BioImaging (EuBI) Node Candidate

What if you could watch a CT scan live, instead of analysing the images afterwards? If it is up to the Leiden mathematician Jan-Willem Buurlage, that will soon be a reality. He is developing methods to make the algorithms behind 3D scans faster. Quite a challenge: ‘Just like mathematicians, computers…

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

Source: Biochem Pharmacol, Volume 95, Issue 4, pp. 290-300 (2015)