Supervisor: Indira Nederpelt

Promotor: Prof.dr. B. van de Water, Co-promotor: L.S. Price

Discovery of metastasis promoting candidate drug targets

A next, general pharmacological problem to be tackled is how drug-target binding kinetics in vivo, affects target occupancy as an important indicator of the time-course of drug effects.

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

In 1940 the Germany occupiers ordered the dismissal of all Jewish staff of the university. This resulted in protest speeches by fellow academics.

Harm reduction in practice: a comparative analysis of the Dutch and Brazilian approach towards drug users.

High-throughput holistic preclinical screens are increasingly used in drug discovery, to assess both drug efficacy and drug safety.

Information about the situation in Ukraine

In Freedom on the Offensive, William Michael Schmidli illuminates how the Reagan administration's embrace of democracy promotion was a defining development in US foreign relations in the late twentieth century.

The War and Peace Studies track offers you a comprehensive understanding of the historical, theoretical, and practical dimensions of war and peace, while addressing the complex challenges of conflict and peacebuilding in the contemporary world.

Lecture

Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…

Teaching excellence is one of the core functions of the War, Peace and Justice (WPJ) research group. WPJ members engage in diverse forms of public engagement, but all share a commitment to education.

Despite the wealth of historical literature on the Second World War, the subject of religion and churches in occupied Europe has been undervalued.

Drugs-related violence in Mexico is similar in terms of dynamics and strategy to the IS hybrid war in the West. This is the claim made by Teun Voeten. PhD defence 20 September.

Why do some civil wars experience quagmire, a situation in which belligerents are trapped in fighting? To explain this puzzle, Jonah Schulhofer-Wohl (Leiden University Institute of Political Science) analyses the overlapping strategic interactions between foreign powers and the warring parties. Studying…

This thesis aims to test in vitro pipelines to rapidly and cost-effectively identify molecular mechanisms that drive adverse outcomes in clinical use.

Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh

Leiden University commemorates its victims of the war and pays tribute to all members of the university community who resisted injustice.

On 11 April 2018, students of the Advanced Master’s in European and International Human Rights Law attended a lecture on the human rights situation in Mexico. The lecture was delivered by Dr. Víctor Avendaño Porras, who lectures and researches at Mexico’s CRESUR (Research Centre on Teaching Formation…

This book explores the lasting legacy of the controversial project by the Congress for Cultural Freedom, funded by the CIA, to promote Western culture and liberal values in the battle of ideas with global Communism during the Cold War.

Can we develop a generic method for Quan/Qual analysis of small molecule drugs, their metabolites and endogenous metabolites in (pre-)clinical samples?

Although rarely considered by the pharmaceutical industry or clinicians, 24-hour rhythms in physiology are a factor of potential influence on the pharmacokinetics and pharmacodynamics of drugs.

Source: ChemMedChem (2015)

During the course of drug discovery translational steps are made.

This thesis describes the importance of being able to control the selectivity of potential drug candidates.

Another research line is the development of a spatial CNS drug distribution model, by ultimately including the 3-dimensional anatomical organization of the CNS.

The War, Peace and Justice group unites scholars and practitioners to explore war dynamics, peace promotion, and justice’s role in conflict and global affairs.

On Wednesday 16 June 2021, Karim Khan was sworn in at the International Criminal Court (ICC) in The Hague. Experts say this is no easy time to join the ICC.

How was anti-communism organized in the West? New volume edited by Giles Scott-Smith, Luc van Dongen and Stephanie Roulin on the aims, arguments and associations of a range of transnational anti-communist activists during the Cold War.

A new special issue on translation and the cultural Cold War sheds light on the understudied and yet important role of translation in cultural transfer.

Heart failure is a major health care problem with high mortality.

From Apartheid in South-Africa to 9/11 in the United States: there is not a single culture that is not shaped by the memory of war or conflict. The minor Cultural Memory of War and Conflict focuses on how such memory cultures influence and shape societies today.

Lecture, Book Talk

On 1 September 2022 Güldeniz Kibris successfully defended a doctoral thesis and graduated.

On the 6th of March 2023, Santino Regilme presented his work-in-progress titled 'Global Drug Wars: Contested Normative Orders of Peace, Security, and Human Rights'. If the battle against illegal drugs is construed as a war, how is victory in such a war defined and constructed? If the oppositional…

This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.

Why do communities form militias to defend themselves against violence during civil war? Using original interviews with former combatants and civilians and archival material from extensive fieldwork in Mozambique, Corinna Jentzsch (Leiden University Institute of Political Science) explains the timing,…

Data analysis with Python and R are rapidly becoming essential skills for modern scientists. Therefore, we are offering courses to develop your scientific computing skills. Those courses are optional for LACDR PhD candidates.

Promotor: A. Kros

Human and animal cells are very complex: very different chemical processes are going on at the same time, but they are separated from each other because the cells are divided in compartments. These compartments may also have a profound effect on the potential efficacy of therapeutics, because the drug…

This volume provides an authoritative, cutting-edge resource on the characteristics of both technological and social change in warfare in the twenty-first century, and the challenges such change presents to international law.

Salvador Santino Regilme has been selected for a fellowship at the Netherlands Institute for Advanced Study (NIAS) in Amsterdam. From September 2022, he will spend 5 months at NIAS working on his research project titled 'The Normative Order of the Global War on Drugs'.

Saeedeh Shahnahpur defended her thesis on 13 September 2016.

Study information

Activity-based protein profiling (ABPP, also termed chemical proteomics), is one of the pillars of chemical biology, and at LED3 we have taken it to the next level. ABPP allows the assessment of protein function in live cells and tissues, which means that the activity of a complete protein family can…

This PhD project investigates the argumentative-rhetorical strategies by which the Russian state attempts to substantiate the legitimacy of its war against Ukraine.

Promotor: A.P. IJzerman Co-promotor: L.H. Heitman