2,288 search results for “social safety” in the Public website
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Whole-cell biosensor for label-free detection of GPCR-mediated drug responses in personal cell lines
Source: Biosens Bioelectron, Volume 74, pp. 233-42 (2015)
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To explore the drug space smarter: Artificial intelligence in drug design for G protein-coupled receptors
Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…
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Host community compensation
Can the offering of host community compensation help to prevent or solve siting controversies, and if so, why and under which conditions?
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Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and
Source: Mol Psychiatry (2015)
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Quality-driven multi-objective optimization of software architecture design: method, tool, and application
Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M.R.V. Chaudron, Co-Promotor: M.T.M. Emmerich
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A document classifier for medicinal chemistry publications trained on the ChEMBL corpus
Source: J Cheminform, Volume 6, Issue 1 (2014)
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Cancer chess: molecular insights into PARP inhibitor resistance
The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…
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Allosteric modulation and ligand binding kinetics at the Kv11.1 channel
Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman
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Executive Board
The Executive Board is responsible for the management and administration of the entire University.
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Vision
The Pharmacy research group focusses on the development of predictive models to improve clinical drug efficacy and safety. We work on clinical problems that require further mechanistic understanding and strive for ultimate benefit to patients.
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Editorial: Sanity and Resilience in Times of Corona
This editorial to RHCPP discusses how COVID-19 can be seen as a 'creeping crisis' according to the authors of its lead article (Boin et al, 2020) and how resilience may depend on the real heroes behind the scenes of response to disaster and adversity.
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Clavis Aurea? Structure-enabled approaches of identifying and optimizing GPCR ligands
Promotores: A.P. IJzerman, H.W.T. van Vlijmen
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Why Leiden University
n an increasingly complex and security-challenged society, the CSM programme, Governance of Violence, provides you with the theoretical and practical skills to understand the issues underlying security challenges and develop solutions for crisis and security management.
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Why Leiden University?
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Exploring big data approaches in the context of early stage clinical
Als gevolg van de grote technologische vooruitgang in de gezondheidszorg worden in toenemende mate gegevens verzameld tijdens de uitvoering van klinische onderzoeken.
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Drug discovery and development
New or improved treatments for chronic and acute illness.
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Overview
The Division of BioTherapeutics at the Leiden Academic Centre for Drug Research (LACDR) is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.
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When structure-affinity relationships meet structure-kinetics relationships: 3-((Inden-1-yl)amino)-1-isopropyl-cyclopentane-1-carboxamides as
Source: Eur J Med Chem (2015)
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Kv 11.1 (hERG)-induced cardiotoxicity: a molecular insight from a binding kinetics study of prototypical Kv 11.1 (hERG) inhibitors
Source: Br. J. Pharmacol., Volume 172, Issue 3, pp. 940-55 (2015)
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Organisation
Organisation of the Leiden Institute of Physics.
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Why Leiden University
In an increasingly complex and security-challenged society, the CSM programme, Intelligence and National Security, provides you with the theoretical and practical skills to understand the issues underlying security challenges and develop solutions for crisis and security management.
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A blessing in disguise?! Discretion in the context of EU decision-making, national transposition and legitimacy regarding EU directives
This dissertation looks into the role of discretion granted by EU directives (Article 288 Treaty on Functioning of the European Union) in legislative decision-making and national transposition processes of these directives.
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Designing a sustainable future for the European Healthcare Sector
The project seeks to develop an eco-design framework for single-use medical devices and packaging
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Interested in sustainable innovation and data?
Are you curious about how science and technology contribute to a sustainable and innovative future? At Leiden University, you’ll explore the world of data, natural laws and living systems. From mathematics to artificial intelligence, from climate challenges to high-tech innovation: you’ll learn to analyse…
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Why Leiden University?
In an increasingly complex and security-challenged society, the CSM programme, Cybersecurity Governance, provides you with the theoretical and practical skills to understand the issues underlying security challenges and develop solutions for crisis and security management.
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Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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Alternative delivery of a thermostable inactivated polio vaccine
In the near future oral polio vaccine (OPV) will be replaced by inactivated polio vaccine (IPV) as part of the eradication program of polio. For that reason, there is a need for substantial amount of safe and more affordable IPV for low-income countries. Bioneedles, which are biodegradable mini-implants,…
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Why Leiden University?
In an increasingly complex and security-challenged society, the CSM programme, Terrorism and Political Violence, provides you with the theoretical and practical skills to understand the issues underlying security challenges and develop solutions for crisis and security management.
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Kinetics for drug discovery – The first step towards an improved drug discovery paradigm
Supervisor: Indira Nederpelt
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Career prospects
Many students receive their first job offer during or right after their Business Studies internship. After graduating you can also aim for a career in Bio-Pharmaceutical research.
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Ariadne SchmidtFaculty of Humanities
a.schmidt@hum.leidenuniv.nl | +31 71 527 2502
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Daniel Carter participated at the Scienceday at the Ministry of Social Affairs and Employment
On 8th October 2018 Daniel Carter presented part of his PhD research on the effects of precarious employment on intra-EU migration at the ‘Science Day’ at the Ministry of Social Affairs and Employment and in the Hague. He presented a paper he is currently working on, which assesses the recent Proposal…
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Navigating Linguistic Diversity: Community Languages and Social Inclusion in the Netherlands
Online presentation
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FGGA experts on freedom: 'We are only truly free when everyone feels free'
On 5 May, we celebrate the liberation of the Netherlands in 1945 and the fact that we have been able to live in freedom ever since. But what does freedom mean, and how does it relate to our safety? Various FGGA experts draw connections with their own fields of expertise.
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Ethical Considerations from Child-Robot Interactions in Under-Resourced Communities
Dr. Eduard Fosch-Villaronga from eLaw collaborates with researchers from the Indraprastha Institute of Information Technology Delhi (IIIT-Delhi) and University of Delhi (DU) in an effort to explore and reflect upon the potential legal, ethical and pedagogical challenges of deploying a social robot in…
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New Year’s reception 2022: towards a new kind of social science
On 11 January 2022, the Faculty of Social and Behavioural Sciences opened the new year during a livestreamed reception. Dean Paul Wouters and Executive Director of Studies Kristiaan van der Heijden were the hosts. After several faculty prizes were awarded, our Dean expressed a new year’s resolution…
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‘Young Academy Leiden wants to stand up for young researchers, especially in difficult times’
Young Academy Leiden (YAL) will change its board this month and welcome seven new members. Outgoing chair Julia Cramer and incoming chair Rachel Plak look back at the highlights of the past year and discuss YAL’s plans for the coming period.
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Andrea Evers’ role in the new Executive Board of PsychologyAndrea Evers’ role in the new Executive Board of Psychology
The new Executive Board of the Institute of Psychology became effective on 1 February 2022. Scientific director Andrea Evers tells us where she gets her energy from.
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Change manager Frans de Haas is working on the future of the MI
Frans de Haas started his work at the MI with a clear mandate. Listening and talking are what he will mainly be doing ‘My role is to make sure that everyone feels comfortable in the new situation.’
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The nation in the city. Urban experience and national agency, Amsterdam 1850-1900 (in Dutch)
My research project focuses on the development of a popular national agency in late nineteenth century Amsterdam and the question how ‘ordinary’ citizens imagined ‘the Netherlands’ through the experience and use of their urban surroundings.
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Paul van TrigtFaculty of Humanities
p.w.van.trigt@hum.leidenuniv.nl | 071 5271349
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The Lazy Mindreader: a new perspective on “mindreading” from the study of language and narrative
How is social cognition shaped by our knowledge of language and stories?
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re-socialise Big Tech? A major study examines the tricks and traps of social media
Humans are increasingly losing agency on social media. A team of legal scholars from Leiden University, computer scientists from other universities and civil society organisations, is conducting a study into the balance of power between Big Tech and users.
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The Impact of Mobility and Migration in the Roman Empire
The Impact of Mobility and Migration in the Roman Empire assembles a series of papers on key themes in the study of Roman mobility and migration.
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Resilient Diversity: the Governance of Racial and Religious Plurality in the Dutch Empire, 1600-1800
Resilient Diversity: the Governance of Racial and Religious Plurality in the Dutch Empire, 1600-1800
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The Future of Dying: End-of-Life Care in a Time of De-medicalized Death
This project investigates ethnographically how patients, their relatives, and healthcare professionals in the Netherlands make decisions about end-of-life care. We study the new dilemmas around what constitutes
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What works in suicide prevention? Lessons from the 113 Helpline
113 Suicide Prevention gave a guest lecture about suicide prevention at the Spanish Steps in Wijnhaven
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Emotions and the psychosocial development of children with and without Developmental Language Disorder
Dissertation
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Archaeologist Jennifer Swerida investigates emergent social complexity in the Omani desert
In June 2024 the Faculty of Archaeology welcomed a new Assistant Professor. Dr Jennifer Swerida, originally from the United States, will strengthen the Faculty’s expertise on the archaeology of West Asia. ‘I explore human-environment relationships inside an ancient oasis and the surrounding land. Previous…
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Responding to the COVID-19 ‘infodemic’: National countermeasures against information influence in Europe
This collection, edited by Sophie Vériter, Monica Kaminska, Dennis Broeders and Joachim Koops, includes six papers exploring and investigating European responses to COVID-related disinformation, specifically the responses of France, Sweden, Germany, the United Kingdom, Serbia, and Hungary.