Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

The mechanism of the electrochemical reduction of dioxygen by a mononuclear pyridylalkylamine copper complex was investigated (see picture). It was shown that in neutral aqueous solution dioxygen undergoes stepwise reduction, wherein hydrogen peroxide plays a key role. The rate constants determined…

An Active Galactic Nucleus (AGN) is a highly luminous region at the center of a galaxy, powered by the accretion into a supermassive black hole and emitting energy from radio waves to gamma rays, often outshining the host galaxy.

Generations of Leiden students and academics have done archaeological research into the early medieval history of Oegstgeest. This makes this old settlement one of the best-documented sites from that era. In a new book, Leiden researchers take stock.

Promotor: J. A. Bouwstra

Through extensive archaeological and documentary research, this study aims to provide a detailed analysis of the maritime cultural landscape of St. Eustatius over the past four centuries. It focuses on bridging the gap between the marine and terrestrial worlds and demonstrates that in order to truly…

This dissertation explores various perspectives on the term immersion, and its relation with, and transformation through, a composer’s practice.

The aim of this thesis is to develop and study a robust and adaptable scaffold for supramolecular polymer self-assembly in water.

Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.

Trust in public institutions in the Tata Steel case and beyond

Planets are formed in disks of gas and dust around young stars.

Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.

Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

Director: Dr. Fred Leemhuis

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

A full overview of THEOR PhD theses.

FSW building, Wassenaarseweg 52, 2333 AK, Leiden

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

Promotor: Prof.dr. B. van de Water, Co-promotores: J.W. van der Laan, C.L.E. Siezen

Promotor: B. van de Water, Co-Promotores: J.H.N. Meerman, F.J. Verbeek

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen

In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

Promotor: Prof.dr. B. van de Water, Co-promotor: L.S. Price

Cardiovascular diseases (CVDs) are the leading global cause of mortality. Endothelial dysfunction, an early reversible stage of CVD development, is marked by decreased nitric oxide production linked to Ca2+ influx in endothelial cells.

Promotor: E.F. Smets Co-promotor: J. Geml

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

High resolution altitude data created by airborne LiDAR allow the investigation of large areas and often inaccessible tracts of land and has the potential to reveal undiscovered archaeological heritage.

PNEC-pro is a user-friendly screening tool for professionals dealing with the assessment of surface water quality. The tool calculates local, watertype specific no-effect concentrations (PNEC) of copper, lead, nickel, and zinc based on biotic ligand models (BLMs).

How are the epidermal lipid pathways involved in health and disease.

The Near East, situated at the nexus of Europe, Africa, and Asia, was central to the development of ancient societies in all three continents.

Promotor: Prof.dr. E Gittenberger, Co-Promotores: C.H.J.M. Fransen, Dr. B.W. Hoeksema

Room 4.28 in the LMUY Building is a dedicated lecture room for the Media Technology MSc program. Finding it for the first time may be challenging. Below is a description of how to find it.

In Indigenous Ancestors and Healing Landscapes Jana Pešoutová presents new interpretations of current healing practices in Cuba and the Dominican Republic juxtaposed against the European colonization of the Caribbean after 1492.

The authors in this volume explore how external innovations (products, technologies, services, institutions and processes) have been appropriated in African societies in order to be acceptable and relevant to local conditions, expectations and demands.

Promotor: C.J. ten Cate, Co-promotor: H.W. Slabbekoorn

Are you eager to dive into a cutting-edge approach to innovation? Do you want to explore how frugality and frugal innovation can drive sustainability? And are you up for an international, real-life challenge? If so, this Leiden-Delft-Erasmus (LDE) minor on frugal innovation is for you!

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

The aromatic infrared bands (AIBs) seen throughout the interstellar medium (ISM) are generally thought to be carried by polycyclic aromatic hydrocarbons (PAHs) and their nitrogen analogues (PANHs).

From the late Middle Ages onwards, maritime conflict has developed hand in hand with international trade. Over time, specific institutions were established to address disputes arising from violence or mishap at sea and in coastal areas. Conflict resolution at sea has mostly been studied through the…

See below for the full programme and abstracts of all papers.

History is being taught at Leiden University since the days of Justus Lipsius [1547-1606]. In 1860, following the appointment of Robert Fruin as Leiden professor of Dutch History, modern historical investigation started in the Netherlands.

Lecture

With the Liveable Communities – Liveable Planet project, Marja Spierenburg, Professor of Anthropology of Sustainability and Livelihood, is showing that scientists are driven by ambition, hope and faith. She is linking Vrouw Vennepolder, a polder in Zuid-Holland, to the UN climate goals.

How do commissions of inquiry operating in conflict situations utilize international law, and how can inquiry findings be utilized by other bodies belonging to the international legal community?

A group of astronomers led by Leiden PhD student Sebastian Zieba has discovered using the James Webb Space Telescope (JWST) that the rocky exoplanet TRAPPIST-1 c has a thin atmosphere. Although the planet is nearly identical to Venus in size and temperature, and was expected to have a thick atmosphere,…