To increase clinical success rate of drugs, a better understanding of drug action mechanism and disease dynamics is required. Metabolomics, which studies small molecules involved in biochemical processes in organisms, has shown to be a useful tool for this better understanding.

The chaotic years after the Civil War are often seen as a time of uniquely American idealism—a revolutionary attempt to rebuild the nation that paved the way for the civil rights movement of the twentieth century. But Adam Fairclough rejects this prevailing view, challenging prominent historians such…

This dissertation presents a grammar of Khwarshi, a Nakh-Daghestanian language.

How to facilitate the translation of science into innovation

Reasserting America in the 1970s brings together two areas of burgeoning scholarly interest.

Promotores: Prof.dr. G. Miley & Prof.dr. J.M. van den Broek

Sarah Giest and Annemarie Samuels, both Assistant Professors at Leiden University, researched the quality and coverage of the data being collected for policiymakers to be used, specifically pertaining to minority groups.

A study on the utilisation of Iron Age rectangular structures and related depositional practices in the Low Countries

Galikyan’s dissertation examines how the multidimensionality of learner­learner interaction data and the multifacetedness of learner-learner interaction itself impact the measurement of learner-learner interaction in digital learning environments.

Galaxies in the local Universe fall into two main categories of spirals and ellipticals. In this Thesis, we explore the structural evolution of galaxies into this bimodal distribution.

Promotores: H.A. Udo De Haes, P.M. Brakefield

Developing new methods for performing improvised music

This dissertation provides an overview of the phonological developments of the Qinghai-Gansu languages, comparing them to the reconstructed ancestral language.

Innovation plays an essential role in firms' competitiveness and long-term success. It varies from different types, ranging from run-of-the-mill innovation that brings incremental changes to existing technologies to radical innovation that breaks from existing trajectories.

This paper critically compares seven widely used risk assessment tools for violent extremism, including the VERA-2R, the ERG 22+, the SQAT, the IR46, the RRAP, the Radar, and the VAF.

This dissertation is about Bayesian learning from data. How can humans and computers learn from data?

Monoacylglycerol lipase (MAGL) is the principal enzyme responsible for hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). MAGL inhibition provides several potential therapeutic opportunities, including anti-nociceptive, anti-inflammatory and anti-cancer activity.

Ferritin is a spherical metalloprotein, capable of storing and releasing iron in a controllable way. It is composed of a protein shell of about 12 nm and within its cavity, iron is stored in a mineral form.

Where did species survive the cold cycles of the current Ice Age?

How does the social infrastructure affect administrative burdens associated with digital government services? The paper 'Administrative burden in digital public service delivery: The social infrastructure of library programs for e-inclusion' published in the Review of Policy Research by Sarah Giest…

Bahar Şimşek defended her thesis on 4 May 2021.

DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.

This thesis is about augmented reality (AR). AR is commonly considered a technology that integrates virtual images into a user’s view of the real world.

Freshwater is an important resource, but at a great risk of species decline due to habitat loss, pollution and over-exploitation, and invasive alien species.

Arco Timmermans, professor by special appointment in Public Affairs at the Institute of Public Administration, is co-editor of this book focused on comparing engagements in policy advisory systems.

This volume considers the military architecture and its impact on local communities in Rome's eastern frontier, which stretched from the north-east shore of the Black Sea to the Red Sea.

Mycorrhizas are symbiotic associations between soil fungi and most plant species.

From Los Angeles to Tokyo, Urban Sociolinguistics is a sociolinguistic study of twelve urban settings around the world.

Promotor: A.W. van der Vaart

This dissertation explores matters of collectivity, drawing from the experience of working with the Amsterdam-based collective Hackers & Designers (H&D).

Key publications of the Biologics Formulation group

Subproject of

On 29 November 2018, Roberto van den Heuvel zijn defended his thesis 'Duidelijkheid van fiscale wetgeving'. The doctoral research was supervised by prof. dr. A.O. Lubbers en prof. dr. H. Vording.

Turning the tables on the misconception that Ezra Pound knew little Greek, this volume looks at his work translating Greek tragedy and considers how influential this was for his later writing.

Understanding the formation and evolution of planetary systems is one of the most fundamental challenges in astronomy. To directly image and study young exoplanets and the circumstellar disks they form from, dedicated high-contrast imaging instruments are built.

The future of Europe as a community of democratic states is deeply uncertain. The European Union, founded to promote ‘ever closer’ integration, aims nominally for peaceful, prosperous cooperation. But this ideal has been battered by a series of bruising crises, and now by war.

This thesis mainly extends the theory of positive operators on Riesz spaces to a setting of pre-Riesz spaces.

This book presents the first comprehensive study of Dime, an endangered Omotic language spoken by about 5400 speakers in south-west Ethiopia. The study presents analysis of the phonology, morphology and syntax of the language as well as a sample of ten texts and an extensive word list.

This thesis presents a thorough survey of the central aspects of the phonology of Shaoxing Chinese from a synchronic perspective and on the basis of recent theoretical phonological developments, with the secondary goal of casting some light on current issues in Modern Chinese (Mandarin).

Sewer pipes are an essential infrastructure in modern society and their proper operation is important for public health. To keep sewer pipes operational as much as possible, periodical inspections for defects are performed.

What drives public agencies’ propensity to engage in more extensive practices and/or to initiate more far-reaching mechanisms of accountability than those mandated by law? In other words, what are the drivers of voluntary accountability?

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

Double Bind. Public service professionals coping with contrasting demands. How do public service professionals align their PSM with contrasting demands set by the organizational and social contexts in which they work?

Xinrong Ma defended her thesis on 13 February 2018

Jaroslaw Kantorowicz, assistant professor at the Institute of Security and Global Affairs, isolated the reaction of the public to the potential breach of constitutional fiscal rules from the reaction of other players, such as the opposition, media and civil society organizations.

This article discusses local expressions of crisis in Beed district, central Maharashtra. Both in public and academic discourse crisis has become the term of choice for the many structural deficiencies which make agriculture an increasingly precarious livelihood in India. While most voices subscribe…

One of the key limitations of the direct imaging of exoplanets at small angular separations are quasi-static speckles that originate from evolving non-common path aberrations (NCPA) to which the primary adaptive optics system is inherently blind. The main focus of this thesis is the development and…

Can we make quantum devices from quantum surprises? And can we explore and build life from the nanoscale up?