6,799 search results for “based” in the Public website
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Phase separation in lipid-based nanoparticles: exploring the nano-bio interface
This doctoral thesis is an effort to understand how lipid phase-separation induced by diacylglycerol analogues in lipid-based nanoparticles affects their in vivo behavior, leading to specific nanoparticle-protein communications and selective cell targeting.
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Multi-functional urban Green space planning based on transdisciplinary learning (MultiGreen)
Green infrastrucuture (GI) like urban farm and green roofs could provide many beneficial functions in cities. These include for example food production, flood prevention or increasing biodiversity. MultiGreen project aims at developing an integrated modelling tool to support…
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A Sociolinguistic Study of an Ewe-based Youth Language of Aflao, Ghana
On the 26th of September, Cosmas Rai Amenorvi successfully defended a doctoral thesis. Leiden University Centre for Linguistics congratulates Cosmas on this achievement!
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Life Cycle Assessment-Based Guidance for development of New Energy Technologies
The development of new environmentally sound technologies is seen as a key route towards achieving sustainability.
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Capillary Electrophoresis-Mass Spectrometry based Metabolomics Approaches for Volume-restricted Applications
Metabolomics is a powerful tool that can provide a comprehensive insight into the complexity of human biology and the pathophysiology of diseases. By analyzing the metabolome, which refers to the complete set of small (endogenous) molecules (with a mass <1500 Da) present within a given biological system,…
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Polypept(o)ide-based Cylindrical Polymer Brushes as Multifunctional Drug Delivery Systems
The polypept(o)ide hybrid material attracted more and more attention over the past decade by combining the multifunctional characteristics of polypeptides with the shielding characteristics of polypeptoid-pSar possessing similar properties as a shielding material as polvethylene glycol(PEG). Polysarcosine…
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Computer Interface Character Speller: Convolutional Neural Network based Methods
A P300-based Brain Computer Interface character speller, also known as P300 speller, has been an important communication pathway, under extensive research, for people who lose motor ability, such as patients with Amyotrophic Lateral Sclerosis or spinal-cord injury because a P300 speller allows human-beings…
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High throughput microscopy of mechanism-based reporters in druginduced liver injury
Promotor: B. van de Water
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oligosaccharide libraries from GBS capsular polysaccharides for structure-based selection of vaccine candidates
Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.
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Literature Overview on Evidence-Based Methods for Academic Development of Senior Teaching Faculty Members
What development pathways support teaching faculty members in research-intensive universities in becoming informal educational leaders?
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Polypept(o)ide-based nanostructures for therapeutic and diagnostic application
Nanoparticles exhibit a number of adjustable properties, e.g., their size, shape, and surface and core chemistry, which can be further diversified with different functional moieties. This opens a broad field for application in diagnostic and therapy. In this respect, the use of a polymeric hybrid material,…
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A Grammar of Awjila Berber (Libya): Based on Umberto Paradisi’s Material
This dissertation provides a grammatical description of the Awjila language, a small Berber language spoken in the Libyan oasis of Awjila.
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Public encounters between Dutch community-based initiatives and government in the governance of sustainability
How can we understand the encounter between communities active in sustainability initiatives and governmental agents at the multiple institutional layers in the Netherlands?
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Gergana VasilevaICLON
g.vasileva@iclon.leidenuniv.nl | 071 5271787
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City tales: an art-based participatory framework for studying migration-related diversity (ARTIVES)
The ARTIVES project studies imaginaries of diversity portrayed by artists in Lisbon and Rotterdam in their films, performances and (oral) literature with the aim to explore their transgressive potential of opening up possibilities of thinking differently about migration-related diversity. Their stories…
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Jia LiFaculty of Science
j.li@liacs.leidenuniv.nl | 071 5274799
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dose metrics for evaluating dose-response relationships of metal-based nanoparticles to Zebrafish embryos
Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver
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Improved Strategies for Distance Based Clustering of Objects on Subsets of Attributes in High-Dimensional Data
This monograph focuses on clustering of objects in high-dimensional data, given the restriction that the objects do not cluster on all the attributes, not even on a single subset of attributes, but often on different subsets of attributes in the data.
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Image-based phenotypic screening for breast cancer metastasis drug target discovery
The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.
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Image analysis for gene expression based phenotype characterization in yeast cells
Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek
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a second language through allusive (precedential) phrases: corpus-based study
This PhD project investigates specific types of allusions used by Russian native speakers, namely references to classical Russian literature. The research includes the analysis of 1) how native speakers use allusions, 2) what type of discourse allusions are frequently used, and 3) how we can implement…
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Squaramide-based supramolecular polymers: from self-assembly to in vivo application
The aim of this thesis is to develop and study a robust and adaptable scaffold for supramolecular polymer self-assembly in water.
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Liposome-based vaccines for immune modulation: from antigen selection to nanoparticle design
Nanoparticles can be used as delivery systems for both small molecules and macromolecules such as proteins, peptides or oligonucleotides. This thesis focuses on the use of liposomes, nanometric vesicles formed by a lipid bilayer enclosing an aqueous core. Liposomes are highly versatile delivery syst…
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Connecting conditionals: a corpus-based approach to conditional constructions in Dutch
On the 26th of January, Alex Reuneker successfully defended a doctoral thesis. The Leiden University Centre for Linguistics congratulates Alex on this achievement!
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Studying the Benefits of Using UML on Software Maintenance: an Evidence-Based Approach.
Including modelling as part of software development appears to have various benefits.
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The Development of the Pivot State Concept Based on Mackinder’s Heartland Theory
The research addresses the question of “what is the impact of geopolitical changes to the pivot states in the Middle East? With special focus on Turkey, Iran and Saudi Arabia.”
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Development of hyaluronan-based dissolving microneedle arrays for dermal vaccination
Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.
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General plant strategies and functions in wetlands: Global trait-based analyses
Wetland plants are distinguished from plants of other terrestrial ecosystems by their adaptations to specific habitat stresses, including waterlogged and flooding and the subsequent abundance of phytotoxic compounds.
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Distance-based analysis of dynamical systems and time series by optimal transport
Promotor: S.M. Verduyn Lunel
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Gaining control of lipid-based nanomedicine by understanding the nano-bio interface
Dit proefschrift beschrijft een collectie aan alternatieve strategieën voor het begrijpen, ontwerpen en toepassen van lipide nanosystemen, waarin de rol van de bio-nano interacties centraal staan. In het bijzonder wordt gekeken naar de interactie van RNA-lipide nanosystemen, bekend van de toepassing…
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crisis communication advisers in crisis response: Applying scenario-based learning
In this article Wouter Jong and Andrea Bartolucci explore the integration of scenario-based learning (SBL) into a crisis communication course to enhance students' practical skills and reflection in real-world contexts.
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Microneedle-based drug and vaccine delivery via nanoporous microneedle arrays
In the literature, several types of microneedles have been extensively described. However, porous microneedle arrays only received minimal attention. Hence, only little is known about drug delivery via these microneedles. However, porous microneedle arrays may have potential for future microneedle-based…
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Jade from the other mountain: Chinese fan fiction based on English source texts
On Friday 22 November 2024 Ye Jiang successfully defended a doctoral thesis and graduated.
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Machine learning-based NO2 estimation from seagoing ships using TROPOMI/S5P satellite data
The marine shipping industry is one of the strongest emitters of nitrogen oxides (NOx), a pollutant detrimental to ecology and human health. Over the last 20 years, the pollution produced by power plants, the industry sector, and cars has been decreasing.
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Mechano-transduction mediated by integrin-based adhesion complexes: integration of cytoskeleton and adhesion dynamics
In this thesis, we focus on novel proteins/mechanisms that regulate integrin-adhesion mediated mechano-transduction.
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Solution in Dissolution: dynamics and fate of metal-based nanoparticles in toxicity assessment
Dissolution processes – next to aggregation processes - play an important role for fate prediction and environmental risk assessment of metal-based nanoparticles (MNPs). It is challenging to predict the kinetics of the dissolution process of MNPs in complex systems such as we can find in in vivo and…
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Urban Waste Learning Hub: Challenge-Based Education in Waste Studies
How can challenge-based learning in higher education contribute to sustainable urban waste management and support The Hague’s transition to a zero-waste city by 2050?
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Profile 6. Developing a parcel based historical GIS of the Netherlands
Historical geo data are gaining in importance. Provided that they are exactly geo referenced, they can be stored into a GIS and thus be combined with all kinds of maps (topographical, pedological, etc.) and datasets. This makes it possible to analyze historical developments in space and time on a detailed…
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Mesoporous silica nanoparticle-based protein delivery systems for biomedical applications
Promotor: A. Kros
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Synthesis and Characterization of Boron, Nitrogen, and Carbon-Based Two-Dimensional Materials
This thesis comprises the development of reproducible synthesis procedures for two-dimensional materials (composed of boron, nitrogen and carbon) on different metallic surfaces.
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Image-based ocular proton therapy: MRI in treatment planning and evaluation
PhD defence
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change and artificial intelligence: The promise and perils of rights-based approaches
Barrie Sander identifies different categories of risks and concern of relying on artificial intelligence technologies to confront climate change.
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Towards a system-based pharmacology approach to predict developmental changes in renal drug clearance in children
Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)
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Identity-Based Role Transitions of Lecturer-Researchers in Higher Professional Education: Linking Research to Teaching and Professional Innovation
How do lecturer-researchers at Dutch Universities of Applied Sciences perceive their academic identity after expanding their teaching-only work portfolios to include researcher roles, and how do they navigate attached identity-based role transitions, while balancing personal goals, institutional expectations,…
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Design and synthesis of metal-based chemotherapeutic agents for targeted DNA interactions or DNA repair pathway modulation
The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…
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What's in the diet? DNA-based analysis for qualitative and quantitative assessment of animal diet
Animal diet studies are critical for understanding ecological processes such as trophic interactions, energy flow, and nutrient cycling. By examining what animals consume, ecologists gain insights into species specialization, predator-prey relationships, and ecosystem management.
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Gintingan in Subang: An Indigenous Institution for Sustainable Community-Based Development in the Sunda Region of West Java, Indonesia
This study attempts to understand how indigenous community institutions pose an important role in sustainable community-based development, including the integration between local culture and development.
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Concepts and applications for evidence-based dosing in morbidly obese patients before and after weight loss surgery
Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst
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of carbohydrate-active enzymes: key insights for sustainable bio-based processes
This thesis examines enzyme domain architecture and engineering to improve the breakdown of lignocellulose and starch, abundant biopolymers crucial for sustainable biofuel and biochemical production. Carbohydrate-active enzymes (CAZymes) facilitate this degradation, but the structural complexity of…
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Rules for a lawless world? Exploring the tension between the ‘rules-based international order’ and international law
The project explores the impact of the clash between defenders of a rules-based order and international law on global governance and the future of legal systems.