In Democratie en totalitarisme zijn de invloedrijkste opstellen van de Franse denker Claude Lefort samengebracht. Lefort laat overtuigend zien dat de kwetsbaarheid van de democratie juist ook haar kracht is. Voor democratie is essentieel dat de macht als ‘lege plaats’ verschijnt. Zij mag slechts tijdelijk…

Nanotechnology has pervaded numerous industrial sectors over the past decades. Although many of us may not be aware of it, nanomaterials are now embedded within many of the the products we use in our daily lives. The agricultural sector might be next in line. Leiden environmental scientists Tom Nederstigt…

BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

This thesis investigates the relations between metabolism and anatomy through the use of Magnetic Resonance Imaging (MRI).

This thesis investigates the evolution and fate of gaseous exoplanets, which are continuously shaped by stellar activity across both short and long timescales.

By growing in a soil plants change the biotic and abiotic properties of the soil in which they grow.

This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

The Leiden Leadership Centre is an international and interdisciplinary network organisation connecting people and perspectives.

Systematisch geordend naslagwerk voor alle stadsrechten in Nederland

HZ Kenniscentrum Zeeuwse Samenleving doet op vraag van regionale overheden en maatschappelijke organisaties onderzoek naar actuele en maatschappelijke thema’s in de provincie Zeeland. De uitkomsten van onderzoeken en analyses worden gebruikt voor kennisopbouw en als basis voor beleidsopbouw en -ontwikkeling.…

Multicopper oxidase, laccase, can efficiently reduce oxygen to water and are mostly used in the enzymatic biofuel cells.

This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.

Sander van Kasteren (Professor of Molecular Immunology) makes the invisible visible. He will explain more in his inaugural lecture.

To explore the potential of marine microorganisms as producers of novel antimicrobial agents and as bioprotectants in aqua- and agriculture, using an integrative, ecology-based strategy for bioprospecting.

This dissertation combines the use of defined microenvironments, high-resolution fluorescence microscopy, and time-resolved analysis, to study intracellular and cellular motility.

Through his project we will unravel the global regulatory networks that control gene expression in Streptomyces bacteria and allow them to properly respond to major changes in the environment; we will then harness this knowledge to activate and identify novel antibiotics

Promotor: A.P.IJzerman Co-promotor: A. Bender

As a contribution to the changing legislation and evolving societal attitudes concerning environmental issues, this project aims to enhance and manipulate the plants’ own natural defense mechanisms against western flower thrips (WFT).

The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.

Inaugural lecture

At Molecular Physiology we teach the following courses within the Leiden Institute of Chemistry's Chemistry and Life Science and Technology programmes.

This dissertation was to develop effective graphene-based nanofluidic devices by developing scalable fabrication methods and elucidating proton transport mechanisms.

Promotor: J. Schaye

Promotor: B. van de Water

This thesis focuses on developing wafer-scale two-dimensional (2D) materials by combining synthesis, transfer, characterization, and device integration of graphene, hexagonal boron nitride (h-BN), and BN-doped amorphous carbon.

The chemical industry must continue to innovate for a more sustainable, healthier society. The reseachers from the Leiden Institute of Chemistry (LIC) contribute by applying their knowledge to themes such as sustainability, energy and health.

The close interaction between organic chemi stry and biology goes back to the late 18th century, when the modern natural sciences began to take shape. After synthetic organic chemistry arose as a discipline, organic chemists almost immediately began to pursue the synthesis of naturally occurring compounds,…

The dark matter of biology: clumps of sugar molecules that, for example, form sugary webs around pathogens. We know very little about them. Wouter Remmerswaal threw all his talent into the challenge – both in the lab and as a modeller – and succeeded. He received his PhD on 12th September.

Lecture

The first steps are made in personalised cancer vaccination strategies, which aim to induce a more specific immune response with fewer side effects. The activation of cytotoxic T cells is crucial for an effective immune response.

Promotor: H.V.J. Linnartz

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

Biopolymer sequencing with graphene edge-based tunnel junctions has the potential to overcome current limitations with the third generation of sequencing based on biological nanopores.

Humanity stands at a pivotal juncture, facing the dual challenge of environmental sustainability and rapid population growth, projected to exceed 11 billion by century’s end.

We simulate interstellar clouds with special plasma expansions and chemical reactions on icy dust grains to be measured in ultra-high vacuum setups. This provides the data necessary to guide and interpret astronomical observations and to model reaction networks in space. [Harold Linnartz]

This thesis provides an overview of the development of the Pair Configuration to Molecular Activity Coefficient (PAC-MAC) model.

This thesis focuses on the design and synthesis of activity-based probes and inhibitors targeting enzymes involved in the degradation of specific plant glycans.

LED3 is the combined effort of three excellent institutes of Leiden University. Through joined hands, we are able to give rise to a more effective early drug discovery pipeline. Let us briefly introduce the three institutes.

How do you engage students? Sander van Kasteren knows how to do that like no other. ‘He compares immune cells to Pokémon and doesn’t just give information; he tells stories,’ students say about their favourite lecturer, Sander van Kasteren. The Professor of Molecular Immunology passionately teaches…

Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.

Our facilities cover:

Lecture