For effective cancer immunotherapy by vaccination, co-delivery of tumour antigens and adjuvants to dendritic cells and subsequent activation of antigen-specific cytotoxic T cells (CTLs) is crucial. In this study, a synthetic long peptide (SLP) harbouring the model CTL epitope SIINFEKL was encapsulated…

How does an embryonic stem cell decide if it becomes a heart cell or a kidney cell? That’s the question computational biologist Maria Mircea studied for her PhD research. She looked at the inside of individual cells to analyse how they change. This is what she discovered.

Thread-like bacteria make cells that no longer have a cell wall under the influence of osmotic stress. A remarkable discovery, since the cell wall serves as a protection barrier for bacteria. It could also help to explain how pathogenic bacteria can hide in our body from our immune system. A team of…

The LUMC has become the first institution in the Netherlands to treat a patient with an autoimmune disease using CAR T-cell therapy.

The Leiden University Medical Center (LUMC), the Danstem Institute from the University of Copenhagen and the Murdoch Children’s Research Institute in Melbourne have received 300m euros from the Novo Nordisk foundation. The aim of this new international consortium is to bring stem-cell based therapies…

An overview of awards and prizes granted to our staff and students in 2019, as well as special appointments and royal distinctions.

Kidney failure is a serious issue because kidneys cannot regenerate themselves after injury. A possible solution consists of artificially growing healthy kidney tissue. To achieve that, scientists first need to understand kidney development during the earliest stages, in the fetus. Leiden researchers…

A new mathematical model may explain how body cells get their shapes and what makes them move within a tissue. The model provides fundamental knowledge for applications in tissue engineering, amongst other things. Publication in open-access journal iScience.

Zebrafish-human communication shows that cancer cells lacking a signaling protein are less able to develop aggressive metastatic properties. This discovery has been made by molecular cell biologist Claudia Tulotta. PhD defence 14 June.

Many teachers in secondary education take differences between pupils into account . PhD research by Saskia Stollman (ICLON) shows that they need room to experiment and the support of the school management

Promotor: Prof.dr. P. Hooykaas, Co-promotor: Dr. R. Offringa

The life of a fibroblast is heavy, but PhD student Julia Eckert makes it 19.5 times heavier, using the Large Diameter Centrifuge at the ESTEC space research centre in Noordwijk.

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…

Chemist Roxanne Kieltyka has received an ERC Starting Grant of 2 million euros. In her lab, she creates gels that mimic the instructive material that supports cells in our body. With the grant, she aims to make these gels stiff and tough, and to create a bio-printed miniature heart ventricle.

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

Cardiovascular diseases are a leading cause of death worldwide, and better models are urgently needed for disease progression studies and drug development.

Biophysicist Rolf Harkes has developed a microscope to optically localize individual molecules in living cells. It improves monitoring of diseases like cancer and Parkinson’s at the cellular level. Defende PhD thesis on t13 January 2016.

Multicellular giant algae Chara species have been widely used in physiological studies for decades.

Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…

PhD defence

The overall theme of this thesis is to complement the electrochemical data acquired in fuel cell research with in situ X-ray photoelectron spectroscopy (XPS) and soft X-ray absorption spectroscopy (XAS).

Prison staff are working under high pressure. The current proposal for cell sharing is the final straw. Associate Professor Esther van Ginneken appeared on Dutch news programme ‘Nieuwsuur’: ‘Serious incidents have occurred, including the murder of a cellmate.’

Embryonic stem cells have the remarkable ability to develop into any type of cell. On their way to become for example a liver or a heart cell, they must repeatedly decide between alternative developmental paths. How they make these decisions is largely unknown. An international team of biophysicists…

Promotor: Prof.dr. J. Kuiper, Co-promotor: Saskia C.A. de Jager

An overview of awards and prizes granted to our staff and students in 2020, as well as special appointments at Leiden University and other institutions.

The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…

Leiden molecular cell biologists in the research group of Annemarie Meijer have discovered novel early macrophage-specific genes in zebrafish, including a signal transducer pivotal for the migration of macrophages in the innate immune response to bacterial infection. Their findings were published on…

The support staff provides support for daily operations, personnel, projects and finances

The Education Office Astronomy supports all aspects of the Astronomy bachelor and master education programmes. Its main focus is on education quality assurance, student monitoring, education-related PR, student recruitment, job market orientation and alumni policy.

Leiden chemists, together with colleagues at the University of York (UK) and Technion (Israel) have discovered a small, sugar-like molecule that maintains the integrity of tissue around a tumour during cancer. This molecule prevents tumour cells from spreading from the primary cancer site to colonise…

Leiden physicists are helping Wageningen plant researchers to study unpredictable plant embryos. For this, they are using a novel two-photon fluorescence microscope, aided by a 30 thousand euro ZonMW grant.

An international group of scientists has discovered that certain cells of our immune system – the so-called T cells – communicate with each other and work together as a team. To fight an infection they stimulate each other’s growth, but at the same time, they inhibit each other when there is a surplus…

The Computer Support group provides dedicated support for the computing infrastructure of Leiden Observatory

With the necessary measures, researchers restart their work in various laboratories. The Leiden Cell Observatory is one of the places where scientists resume their lab work.

When the immune system attacks cancer, the tumour modifies itself to escape the immune reaction. Researchers at LUMC published on this subject in Nature on 28 June.

The directorate of Leiden Observatory consists of the Scientific Director, the Director of Education and the Director of Operations.

Are Weyl particles the ideal conductors? Do cells without a cell wall play a role in chronic Tuberculosis infections? Carlo Beenakker and Dennis Claessen want to answer these questions. They both received a KLEIN grant from the NWO. With these grants, NWO wants to stimulate innovative, fundamental r…

Three speakers, three fascinating science stories and a well-filled lecture hall. The Niko Tinbergen Lecture had a successful restart on 10 December 2019.

Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.

Researchers from the Netherlands Cancer Institute, the Leiden University Medical Center (LUMC) and Oncode have created a tracking system that can reveal how often cells have divided. This allowed them to find a yet undiscovered population of immune cells: young memory cells that behave like stem cells.…