1,443 search results for “wezel van medewerker” in the Public website
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Signalling pathways that control development and antibiotic production in streptomyces
Bacteria are highly complex and diverse organisms that have adapted to survive in ecological niches ranging from the most extreme to the most heterogeneous environments.
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Piecing together the regulatory puzzle: Advancing natural product discovery in Actinobacteria
PhD defence
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Towards a Structural Understanding of Plant─Microbiota Interactions using cryo-EM Techniques
PhD defence
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Identifying novel genetic causes of familial colorectal cancer
PhD defence
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Valedictory lecture prof.dr. J.M.A. van Gerven
Valedictory lecture
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Van Willigen, ‘A Dutch return to UN peacekeeping?’
Niels van Willigen (Institute of Political Science, Leiden University) puts Dutch participation in UN peacekeeping into an historical context. He analyses the reasons for the Dutch withdrawal from the 1990s onwards, and explores the obstacles and opportunities for a structural return. Van Willigen argues…
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Louwerse, Otjes & Van Vonno, The Dutch Parliamentary Behaviour Dataset
Political scientists Tom Louwerse, Simon Otjes & Cynthia van Vonno introduce the Dutch Parliamentary Behaviour Dataset, a record of parliamentary (voting) behaviour in the Dutch Tweede Kamer (Second Chamber, House of Representatives) since 1945.
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De beloning van curatoren bij lege boedels (NL)
This publication is written in Dutch. Please consult the Dutch page for more information.
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De bescherming van persoonsgegevens, Acht Europese landen vergeleken
The Netherlands generally performs above average in the protection of personal data, according to research carried out at Leiden University. Germany is the leading country, while countries such as Italy and Romania are lagging behind.
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De strafbaarstelling van mensenhandel ontrafeld
On 25 September 2019, Luuk Esser defended his thesis 'De strafbaarstelling van mensenhandel ontrafeld'. The doctoral research was supervised by Prof. C.P.M. Cleiren and Prof. J.M. ten Voorde.
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De politiek van Europees beleid
Book project on how European policy is made and implemented, with a focus on how that process can be understood and lead to policy change.
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Beginsel en begrip van verdeling
On 22 November 2018, Teico Sikkema defended his thesis 'Beginsel en begrip van verdeling'. The doctoral research was supervised by Prof. mr. W.G. Huijgen and Prof. dr. F. Sonneveldt.
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Onderzoek naar praktijk van overheidsgeheimhouding
De overheid moet in een democratie openbaarheid nastreven, maar soms is geheimhouding noodzakelijk om belangen als veiligheid of privacy te beschermen. De Wet open overheid (WOO) bevat daarom een recht op overheidsinformatie, maar staat ook uitzonderingen daarop toe om in de wet gespecificeerde belangen…
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De lichtheid van literatuur: Engagement in de multiculturele samenleving
De lichtheid van literatuur: Engagement in de multiculturele samenleving (The Lightness of Literature: Engagement in the Multicultural Society) is a plea for the social relevance of literature. The book delves into an age-old debate about literature and social engagement, which has recently been reinvigorated…
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De aanpak van ondermijning en financieel-economische criminaliteit
Deze onderzoeksgroep richt zich op het thema ondermijning en financieel-economische criminaliteit, in het bijzonder de aanpak ervan op een aantal deelterreinen.
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Opgezogen, opgespoten en opgeraapt: Vuurstenen en hardstenen artefacten van de Zandmotor en hun sedimentaire context
Voor zowel archeologen, paleontologen en geologen als vrijwilligers in de archeologie en paleontologie is het geen verrassing meer dat op de stranden van de Nederlandse kust fraaie vondsten gedaan kunnen worden. Vele artikelen, boeken, tentoonstellingen, congressen, lezingen, ‘zoekdagen’, krantenberichten,…
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Veranderend kunstenaarschap - De rol en betekenis van de kunstenaar in participatieve kunstpraktijken
De positie van kunst en kunstenaars in de westerse samenleving
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AI in beeld - Mogelijkheden, risico’s en richtlijnen van kunstmatige intelligentie voor de beeldende journalistiek
Met AI kunnen nieuwsredacties razendsnel beelden genereren — maar tegen welke prijs? Dit onderzoeksrapport opgesteld door prof. dr. Jaap de Jong, dr. Astrid Vandendaele, Maartje van der Woude en Stef Arends (Universiteit Leiden), baseert zich op 59 interviews met beeldmakers, redacteurs en experts uit…
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Vermeerderd en verrijkt: de eerste gravures van de Leidse universiteit naar Jan Cornelisz. van 't Woudt beschouwd vanuit een stedelijke context
On Thursday 30 May 2024 Corrie van Maris successfully defended a doctoral thesis and graduated.
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Controlling growth and morphogenesis of the industrial enzyme producer Streptomyces lividans
Promotor: Prof.dr. G.P. van Wezel, Co-Promotor: E. Vijgenboom
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Analysis of the angucycline biosynthetic gene cluster in Streptomyces sp. QL37 and implications for lugdunomycin production
Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.
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Group benefits from genomic instability: a tale of antibiotic warriors in Streptomyces
Streptomyces are filamentous bacteria that produce more than two-thirds of known antibiotics.
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Anthracycline biosynthesis in Streptomyces: engineering, resistance and antimicrobial activity
Actinobacteria are well known for the production of bioactive natural products, many of which have applications in the fields of human, animal and plant health. Subject of this thesis are the anthracyclines, glycosylated aromatic polyketides with potent anticancer activity.
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Another Brick in the Wall: The role of the actinobacterial cell wall in antibiotic resistance, phylogeny and development
Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.
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Exploring the metabolism and toxicity of amino sugars and 2-deoxyglucose in Streptomyces
Streptomyces are prolific producers of enzymes and secondary metabolites, including more than 50% of all clinical antibiotics. This makes them highly attractive for medical, biotechnological, and industrial purposes.
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Ecology and genomics of Actinobacteria and their specialised metabolism
Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.
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Cryo Electron Tomography Studies On Bacterial Chemosensory Arrays
Bacterial chemosensory arrays are protein assemblies that are the key structural and functional component for motile bacteria to sense their internal or environmental chemical signals.
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The Ecology and Evolution of Microbial Warfare in Streptomyces
The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.
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Impact of plant hormones on growth and development of actinobacteria
Plants are colonized by an astounding number of microorganisms that can provide different life-support functions, including nutrient acquisition and protection against (a)biotic stresses like drought or pathogen attack.
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Molecular characterization of copper-dependent enzymes involved in Streptomyces morphology
Promotor: G.P. van Wezel, Co-promotor: D. Claessen
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Expanding the chemical space of antibiotics produced by Paenibacillus and Streptomyces
Antibiotic-resistant bacteria pose a major health threat. Addressing this challenge requires among others the development of new antibacterial compounds. The research described in this thesis focuses on discovering novel antibiotics from soil bacteria, specifically Streptomyces and Paenibacillus.Despite…
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Structural and functional analysis of proteins involved in natural product biosynthesis and morphological differentiation in Streptomyces
Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.
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Exploring the chemical space of post-translationally modified peptides in Streptomyces with machine learning
The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.
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Volatile compounds from Actinobacteria as mediators of microbial interactions
Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.
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Mechanisms and consequences of horizontal gene transfer in cell wall-deficient cells of Kitasatospora viridifaciens
The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…
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Identification and characterization of developmental genes in streptomyces
Promotor: Prof.dr. G.P. van Wezel
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Morphogenesis and heterogeneity in liquid-grown streptomyces cultures
The filamentous bacteria Streptomyces are widespread inhabitants of terrestrial soils.
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Exploring and exploiting the mechanism of mycelial pellet formation by Streptomyces
Promotor: G.P. van Wezel
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Target Discovery
The goal of target discovery is to identify and validate proteins and biological pathways that are involved in the disease process. Modulating these target proteins and pathways with small molecules, therapeutic proteins or other biomolecules (e.g. mRNA) could deliver an effective and safe drug or v…
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Structural characterization of bacterial proteins involved in antibiotic resistance and peptidoglycan biosynthesis
This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.
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Exploring the chemical space of natural products from Streptomyces using multi-omics approaches
The increasing resistance of pathogenic bacteria to antibiotics necessitates the discovery of new medicines.
- Effatha-gebaren - Het ontstaan van een dialect in Nederlandse Gebarentaal
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H.J. van Mook and Good Governance in Indonesia and the World
Was the progressive colonial civil servant the precursor of the postcolonial development-aid worker?
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Een gedreven buitenstaander: J.H. van 't Hoff de eerste Nobelprijswinnaar voor Scheikunde
This dissertation presents a new perspective on the life, work and character of the Dutch physical chemist Jacobus Henricus van ’t Hoff, first recipient of the Nobel Prize in Chemistry, and one of the most important and colourful scientists in Dutch history. The image of Van ’t Hoff that emerges from…
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De leefwereld en denkbeelden van Nederlandse & Belgische syriegangers: een analyse van elf facebook-accounts
You can find more information on the Dutch webpage. Click on the “Nederlands” button above.
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De rol van de curator bij de aanpak van onregelmatigheden (NL)
This publication is in Dutch. Please consult the Dutch page.
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Verandering van geloofsvoorstelling: Analyse van legitimaties door Antony Flew, Cees Dekker en Raymond Bradley
Michiel Pronk defended his thesis on 30 March 2016
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Toepassing en rechtskarakter van de groepsvrijstelling van artikel 2:403 BW (NL)
This publication is in Dutch.
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De invloed van de woonplaats op de fiscale behandeling van grensoverschrijdende werknemers
On 14 November 2019 Niek Schipper defended his thesis 'De invloed van de woonplaats op de fiscale behandeling van grensoverschrijdende werknemers'. The doctoral research was supervised by Prof. S.C.W. Douma and Prof. J.P. Boer.
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Vrijheid van meningsuiting en de bestrijding van discriminatie in Nederland: een constitutioneel ontwikkelingsperspectief
PhD defence