Plants produce an astonishing variety of secondary metabolites (SMs) which are thought to play vital roles in the fitness of plants through ecological interactions.

Promotor: A.P. IJzerman

Nature, nurture and neural mechanisms of social emotion regulation in childhood

Source: Biosens Bioelectron, Volume 74, pp. 233-42 (2015)

On the 19th of November, Tingting Zheng successfully defended a doctoral thesis. Leiden University Centre for Linguistics congratulates Tingting on this achievement!

Promotor: A.P. IJzerman

Beneficial plant-associated microbiota, particularly those inhabiting the rhizosphere, contribute substantially to plant health through pathogen suppression, stimulation of plant defence responses, and enhanced nutrient acquisition.

Smart algorithms and powerful processors are just as essential for astronomy as big telescopes. Astronomers at Leiden University therefore constantly operate at the interface between astronomy and data science.

To get a feeling of how we operate at LED3 when it comes to Early Drug Discovery, please browse through our case studies. When you select a case study you’ll find relevant contacts.

Promotor: Prof.dr. M. de Jong, Co-Promotor: Dr. A.J. Heijboer

This thesis focuses on the study of transient and variable radio sources in the universe.

Gold nanorods are biocompatible nanoparticles that present an excellent two-photon signal that can be used to get high spatial resolution inside living cells. Gold nanorods are photostable and therefore can be followed inside cells for long time, with possible applications as trackers in live cells.

In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.

The Centre for Digital Heritage undertakes collaborative international research in the field of Digital Heritage. It is an initiative of the University of York.

So-called

Playing the piano with your forearm, plucking the strings, sawing through the piano: pianist Luk Vaes's doctoral dissertation covers all the techniques of play for which a piano is NOT designed. His defence ceremony will consist of three concerts and a public defence. 'Musicians were using the interior…

Arts and leisure, Arts and leisure

This project employs a systematic experimental approach to examine the interaction of these two hitherto independent lines of research (tone sandhi and focus realization) in six dialects of Chinese, which lie on a continuum between dialects with dense tonal distributions and sparser distributions. In…

In order to gain insight into the structure and function of the molecular complexes involved in chemotaxis, we use electron cryotomography (ECT). This technique allows us to directly study microbes in their native state at resolutions capable of visualizing individual proteins.

How does stress affect different components of behavioral impulsivity and aggression in patients with Borderline Personality Disorder compared to clinical controls (patients with Attention Deficit Hyperactivity Disorder) and healthy controls?

Can Zebra finches learn to distinguish two very similar Dutch words? Research by behavioral biologist Verena Ohms proved that they can identify 'wit' and 'wet'. Ohms published her findings in

Promotor: Prof.dr. E.J.J. Groenen

Promotor: Erik F. Smets, Co-promotores: Barbara Gravendeel, Niels Raes

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

This article discusses the impact of symbolic gender representation on the willingness of citizens to coproduce.

We study cell-fate decision-making using embryonic stem cells as a model system. Stem cells integrate a large number of cues to direct their development into a great variety of cell types.

Schuurman examines how Russia is escalating its covert operations against European countries.

Dynamic nuclear polarization with paramagnetic agents can enhance nuclear magnetic resonance signals by orders of magnitude. The mechanism of enhancement depends a.o. on the magnetic resonance properties of the agents used. Electron spin relaxation times at NMR relevant magnetic field/microwave frequencies,…

This dissertation derives from the development of tools for algorithmic composition which extract pitch materials from sound signals, analyzing them according to their timbral and harmonic properties, putting them into motion through diverse rhythmic and textural procedures.

Endocannabinoids are lipid messengers that modulate various physiological functions by activating the cannabinoid CB1 and CB2 receptors. While the metabolism of endocannabinoids and their action at the CB receptors is fairly well studied, the molecular mechanisms governing their release and transport…

In this work the reconstruction of a tau neutrino signal in the KM3NeT detector is discussed.

Humanities Campus Project is the name of the redevelopment of the Witte Singel-Doelen Complex, the location of the Faculty of Humanities and associated knowledge partners and institutes. Over a period of ten years the complex will undergo a gradual metamorphosis, while classes continue to be taught.…

In this 3-volume set of primary sources, Lionel Laborie and Ariel Hessayon bring together a wide range of vital sources for the study of prophecy in the early modern world. This meticulously edited collection includes rare material and fascinating manuscripts published in English for the first time.

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

The subject areas covered encompass functional genomics, signal transduction, cellular differentiation, development, host-microbe interactions and animal behaviour.

PhD defence

I suggest a systematic study into the influence of non-singing female companions on vocal learning in young birds as a proof-of-principle study into how non-imitative learning processes from the social environment influence the timing and content of vocal learning and thus drive the interface between…

I am passionate about aquatic ecology, conservation and evolution, behavioural biology and global change. During my PhD, I am investigating the density and diversity of pelagic fish in and around offshore windfarms in the North Sea, more specifically related to the underwater acoustic conditions. This…

Dörner is interested in animal behaviour, neuroethology, ecology and anthropogenic effects on animal behaviour and species dynamics. The focus of her PhD is on the effects of light and noise pollution on migratory fish.

Electric noise can be useful for scientists but inconvenient for chip manufacturers. They do share a wish to predict the amount of noise. PhD student Sumit Tewari overturns a century-old law relating noise to current. He defends his thesis on March 27th.

Leiden University social scientists have shown that customised intervention pays off. A new fundamental research-based approach in children who are in danger of going off the rails has delivered spectacular results.

The Chemical Probe Facility is part of the Leiden Early Drug Discovery & Development (LED3) center. Activity-based protein profiling (ABPP) is one of the pillars of chemical biology. ABPP determines the activity of entire protein families in living cells and tissues under physiological conditions, such…

Leiden University neuropsychologists have shown that customised intervention pays off. A new fundamental research-based approach in children who are in danger of going off the rails has delivered spectacular results.

Neural networks have a wide range of applications. In Leiden, psychologists use them to build robot brains, whereas archaeologists use them to hunt for prehistoric graves.

The goal of hit and lead optimization is to optimize suitable chemical starting points that can modulate a drug target. The methods and technologies used are similar to those in Hit Discovery, but once the compound has shown activity in an animal model, it moves from 'hit' to 'lead.'

The methodology helping us to prepare for and shape preferred futures.

This project, under the supervision of Prof. Dr. Hans van der Plicht, comprises several studies aimed at the use of isotopes occurring naturally in organic material as tracers for both the climate change and its cultural impact at about 6200 BC. The research will be carried out by the co-applicant at…

Here I propose to study the relationship between autonomic pupil-synchronisation and trust, at the behavioural and neural level, and examine a targeted set of possible contextual moderators.