On 29 January 2019, Robbert van Eijk defended his thesis 'Web Privacy Measurement in Real-Time Bidding Systems, A Graph- Based Approach to RTB system classification'. The doctoral research was supervised by Prof. dr. H.J. van den Herik.

Does a universal psychoeducational course about stress in adolescents: I) lead to an increase in knowledge of stress?, II) affect the frequency with which stressors are experienced and the overall stress level?, III) create interest in a tier 2 level follow-up training?, and IV) appeal to students in…

The authors systematically search and review relevant definitions of Security by Design (SbD) in comparison with Privacy by Design (PbD).

Develop a tool to assess land tenure, access to land and, and land tenure conflict in Timor-Leste

What relationships exist between different types of PLCs and cognitive differentiated teaching?

On 7 May 2020, Jolanda van der Vliet defended her thesis 'The International Legal Protection of Environmental Refugees. A human rights-based, security and State responsibility approach'. The doctoral research was supervised by Prof. N.J. Schrijver and Prof. J.J.C. Voorhoeve.

The drug BIA 10-2474 inhibits fatty acid amide hydrolase (FAAH), a lipase that degrades a specific endocannabinoid. On the basis of this activity, BIA 10-2474 was being developed as a potential treatment for anxiety and pain. In a phase 1 trial of the drug, one subject died, and four others suffered…

PURPOSE: In the present study we investigated the root-cause of an interference signal (100-200 nm) of sugar-containing solutions in dynamic light scattering (DLS) and nanoparticle tracking analysis (NTA) and its consequences for the analysis of particles in biopharmaceutical drug products.

On 7 September, Francesc Claret Traid defended the thesis 'On the nature of the right to resist: a rights-based theory of the ius resistendi in liberal democracies'. The doctoral research was supervised by Afshin Ellian and Gelijn Molier.

Tuberculosis (TB) is a major global health problem caused by the bacterium Mycobacterium tuberculosis (Mtb). In 2015, there were estimated to be 10.4 million new cases and 1.8 million deaths ascribed to TB, making it one of the top 10 causes of death worldwide. Unfortunately, the only current registered…

Poly(lactic-co-glycolic acid) (PLGA) particles have been extensively studied as biodegradable delivery system to improve the potency and safety of protein-based vaccines. In this study we analyzed how the size of PLGA particles, and hence their ability to be engulfed by dendritic cells (DC), affects…

A high-end label: Cyclophellitol aziridine-type activity-based probes allow for ultra-sensitive visualization of mammalian β-glucosidases (GBA1, GBA2, GBA3, and LPH) as well as several non-mammalian β-glucosidases (see picture). These probes offer new ways to study β-exoglucosidases, and configurational…

The emergence of complex diseases resulting from abnormal cell-cell signaling and the spread of infectious diseases caused by pathogens are significant threats to humanity. Unraveling the dynamic mechanisms underlying cell-cell signaling and infectious disease spreading is crucial for effective disease…

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.

The manual analysis of remotely-sensed data is a widespread practice in local and regional scale archaeological research, as well as heritage management.

We found that, next to the effectiveness of the intervention, it’s also very likely that the intervention is cost-effective compared to attention only.

What is the effectiveness of (booklet or online) self-help programmes for people with somatic stressors and depressive symptoms? What works best for whom? How to improve motivation and adherence?

With the What's Next? series we hope to inspire current Media Technology MSc students, show the variety of paths taken after the studies, and bring together alumni. Editions of the series are generally organized around a particular theme by Media Technology MSc students themselves, and followed by social…

Markus Altena Davidsen’s PhD dissertation is the first major study of Tolkien Religion. In it, he analyses the religion that is based on the stories by acclaimed British fantasy author J.R.R. Tolkien. He also discusses how fiction itself can become religious. Davidsen will defend his dissertation on…

Assistant Professor Vedran Dunjko and his team received a gift from Google to support their quantum research. The research focuses on whether quantum computers can provide new ways of understanding the mysteries of high-energy physics.

A mix of data research, artificial intelligence and archaeology led to lively discussions on 31 January. On that day the unique event 'AI & Data Science @ Archaeology' took place in which the Data Science Research Programme (DSRP), SAILS and the Faculty of Archaeology joined forces.

What is and should be the role of universities in supporting business? How can business benefit more of relationships with science? And what is the role of policy makers in supporting a productive relationship between science and business? Professor Simcha Jong Kon Chin examines the interactions between…

From March 2023, political scientist Katharina Natter (Leiden University) will lead part of an ambitious project called PACES, funded by Horizon Europe and coordinated by Simona Vezzoli (ISS). PACES is an innovative, inter-disciplinary and multi-level research project that offers a groundbreaking approach…

Many astronomers suspect that most of the matter in the universe is invisible. So how can you weigh dark matter if you can't actually see it? Professor Henk Hoekstra is looking for a solution. Inaugural lecture 25 June.

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

Exploring metabolomics-based biomarkers for diagnosis and treatment response monitoring of community-acquired pneumonia

This thesis aimed to investigate core cross-linked polymeric micelles (CCPMs) and expand their potential for the delivery of hydrophobic drugs and co-factors.

Rutger Leukfeldt, special chair of Governing Cybercrime, and colleagues investigate the link between Protection Motivation Theory (PMT) factors and self-protective online behavior.

For a successful implementation of an educational reform, teachers need to regard the proposal as being practical. I used a modular, success-oriented approach to make a context-based reform practical for implemtentation in Duthc biology education. educational reform, modular, teachers, biology, success-oriented,…

In this blog post, Linda Slapakova discusses the various roles that AI plays in counter-disinformation efforts, the prevailing shortfalls of AI-based counter-disinformation tools and the technical, governance and regulatory barriers to their uptake, and how these could be addressed to foster the uptake…

By delivering his inaugural lecture titled ‘Where Science Meets Business,’ Simcha Jong accepted his appointment as Leiden’s first Professor of Science Based Business. In his lecture in the Large Auditorium of the Academy Building, Simcha argued that broad universities with a focus on fundamental research,…

The registrations for the Science Based Business specialisation of the Fall 2017 (Management track, starting in September) has now been opened, and it is thus now possible to apply. The ability to apply for the New Technology Ventures track will also follow soon.

Two new Assistant Professors are joining Science Based Business (SBB) this Autumn. ‘Xishu Li and Jian Wang are the first two Assistant Professors we recruited. This is an exciting, crucial next step for SBB,’ said Professor Simcha Jong who joined Leiden University as the Director and first Professor…

Science communication is a lot more than writing a column or giving a lecture now and then. The communication itself also has to be firmly based in sound scientific research, is the message of Professor Ionica Smeets in her inaugural lecture.

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

New research has confirmed that the Dutch military used systematic, extreme violence against Indonesians. In his book Soldaat in Indonesië (Soldier in Indonesia), to be released at the end of October, historian Gert Oostindie draws the same conclusions using different sources. He presents new findings…

A modeling approach with applications to the Bau de l'Aubesier (Southeastern France)

The research described in this thesis centered on retaining exo-β-glucosidases implicated in health and disease, in particular the human inherited lysosomal storage disorder, Gaucher disease (GD).

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

National Meat Free Week (Nationale Week Zonder Vlees, 7–13 March) is an initiative to reduce meat consumption. Assistant professor Paul Behrens is studying what impact a change in our food consumption would have on the world. What, according to him, are the main reasons to switch to a (mainly) plant-based…