Supervisor: Andrea Martella

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: J.D.C. Codee

The work in this thesis has been focused on two subjects. The first is the assembly of alginate oligosaccharides and the generation of building blocks for the enzymatic synthesis of alginate, and the second is the total synthesis of large fragments of the zwitterionic SP1 polysaccharide.

The primary goal of this research is to deepen our understanding of substrate-enzyme interactions in Glycoside hydrolases. For this purpose, Bacillus circulans xylanase (BcX) has been selected as a well-established model to examine the Michaelis complex and glycosyl-enzyme adduct.

Potential drugs that seem promising in the lab, but don’t show any activity in a person: they cost the industry an incredible amount of time and money. That’s why Indira Nederpelt focuses on a more efficient search for new drugs in her PhD, by determining the kinetics of a potential drug earlier on…

On Monday 22 November 2021, the Municipality of Leiden, Leiden Law School and the Legal Advice Centre in Leiden signed a collaboration agreement. The parties agreed that at the request of the Municipality, the Law School will help train students to better equip them in their work on the Rental Team…

Not taking into account the saturation of drug targets can lead to wrong conclusions about the duration of a drug's action. This is what former PhD candidate Wilbert de Witte writes together with the Leiden professors of pharmacology Meindert Danhof, Piet van der Graaf, and Liesbeth de Lange in Nature…

Supervisor: Xue Yang

In this research group, headed by Laura Heitman, novel receptor concepts in drug discovery are studied, aiming to increase the effectivity of medicines. Many drugs act via so-called G protein-coupled receptors (GPCRs) and therefore our research is mainly focused on understanding and improving drug-receptor…

An overview of research projects at the Predictive Pharmacology group.

The receptor nomenclature committee of IUPHAR, the International Union of Pharmacology, has several subgroups. Among these are a few that our division is involved in, those for adenosine, nicotinic acid, and GnRH receptors.

What does life look like after International Studies? For Chris Colijn who graduated in 2018, it involves working on his master’s in Russian and Eurasian Studies, in combination with a bustling traineeship for “Raam of Rusland”, a think tank, focusing on Russian and Ukrainian politics, economy and culture.…

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

Membrane proteins and membrane interactions of proteins are studied by spin label EPR. Intact, native membranes, vesicles of all sizes and nano-disks can be investigated, because the size of the object does not matter in EPR. Whereas solution NMR is limited to micelles (a few nm in diameter), by EPR…

This thesis examines enzyme domain architecture and engineering to improve the breakdown of lignocellulose and starch, abundant biopolymers crucial for sustainable biofuel and biochemical production. Carbohydrate-active enzymes (CAZymes) facilitate this degradation, but the structural complexity of…

G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.

ASLU 14

The Leiden Slavery Studies Association (LSSA) is dedicated to promoting a greater understanding of slavery and post-slavery in any period and any geographical region.

Leiden University is the first Dutch university to join the Healthy Universities international network. Lifestyle workshops, rewards for good behaviour and the latest interventions encourage students and staff to live more healthily. The experiences gained through this network will be used in scientific…

Presenting a well-thought-out idea to Schiphol experts, a former ambassador or a security expert. For the third-year Security Studies bachelor students, this was a unique experience and a great opportunity last week. 'Who knows, maybe they can work for us in the future!'

Expand your knowledge, gain international experience, and explore global challenges. From summer schools and online courses to virtual exchanges, Leiden University students at all levels (bachelor’s and master’s students, and PhD candidates) can participate in a range of learning opportunities.

The AI chatbot ChatGPT has a clear left-liberal bias when filling in the Stemwijzer voting advice application. This was discovered by master's student Merel van den Broek during an assignment for the Machine Learning for Natural Language Processing course.

Are you thinking about studying Film and Photographic Studies? Learn more and watch the introduction video.

Are you thinking about studying Book and Digital Media Studies? Learn more and watch the introduction video.