How citizens and professionals are the key to successful collaboration in the delivery of public services. How do individual characteristics of citizens and professionals influence citizen-professional collaboration in the co-production of public services?

Isis on the Nile. Egyptian gods in Hellenistic and Roman Egypt

Promotores: Prof.dr. J. Aarts, Prof.dr. J.M. van Ruitenbeek

In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

The local ordering of atoms at the surface of a metallic particle determines its catalytic activity and selectivity. As energy systems of the future will be based on efficient catalytic conversion of small molecules in closed cycles, we study how structural effects of catalysts can be used to our ad…

For present purposes, it is important to distinguish between an early period of settlement, about 6800-6200 BC, and a late period, about 6200-5800 BC, at Tell Sabi Abyad.

The work presented in this thesis addresses the role of the locus coeruleus (LC) - norepinephrine (NE) system in various aspects of human cognition, and the modulation of brain state.

In this thesis, we study travelling waves in stochastic reaction-diffusion equations. We extend techniques from the deterministic theory for travelling waves to apply to the stochastic version, which allows us to compute the stochastic wave speed and shape, and draw conclusions on the stability of the…

Promotores: F.H.J. Redig, W.T.F. den Hollander

PhD defence

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

The emergence of complex diseases resulting from abnormal cell-cell signaling and the spread of infectious diseases caused by pathogens are significant threats to humanity. Unraveling the dynamic mechanisms underlying cell-cell signaling and infectious disease spreading is crucial for effective disease…

Grammatical gender is famously the most puzzling of the grammatical categories. We have a solid typology of gender systems, yet exciting and unexpected patterns keep turning up which defy easy classification and straightforward analysis. Some of these question, stretch or threaten to cross the outer…

We study the physics of a broad range of biological and soft materials

This book explores the boundaries of the category of gender and their theoretical significance within the framework of Canonical Typology.

At Leiden University we believe it is important that you receive the right kind of support in your choice of study and while you study. This is why we use what we call the ‘Leiden study system’ to help you make a success of your study from start to finish.

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

The dissociative chemisorption of methane on metal surfaces is of fundamental and practical interest, being a rate-limiting step in the steam reforming process. The reaction is best modeled with quantum dynamics calculations, but these are currently not guaranteed to produce accurate results because…

DIGIFOOD is a transnational research project that investigates how data governance can support equitable and sustainable digital food systems. Around the world, digital technologies are transforming agriculture. Sensors in soil, satellites in space, and mobile phones in farmers’ hands are generating…

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

My ERC Starting Grant, funded with €1.5 million for 5 years as part of the Horizon 2020 research and innovation program, is focused on building the early warning system WARN-D to reliably forecast depression in young adults before it occurs. Why depression, and why prediction?

This research tries to create a coherent comprehension of misfit, enhance conceptual knowledge, highlight prevalent knowledge.

The European Council and the European Commission have a similar role in agenda setting. Both place issues on the EU agenda. However, these institutions have distinct designs. They have different political attributes (the European Council has considerably more political authority) and information-processing…

In this article, Marco Cinelli, assistant professor at Leiden University College The Hague, examines proper and improper uses of Multiple Criteria Decision Analysis (MCDA) methods in energy systems analysis.

Is system thinking through perspectives the solution for biology education to help students see the connections between different topics?

Uncovering task solving processes in dynamic testing

Increasing above- and belowground biodiversity in arable leek cultivation to stimulate pest control by natural enemies.

Promotor: Prof.dr. E.F. van Dishoeck, Prof.dr. F.F.S. van der Tak (RUG)

Healthcare Information Systems (HIS) are essential for modern healthcare delivery, yet their development faces significant challenges including heterogeneous data formats, regulatory compliance, and the growing demand for AI-driven decision support.

To increase clinical success rate of drugs, a better understanding of drug action mechanism and disease dynamics is required. Metabolomics, which studies small molecules involved in biochemical processes in organisms, has shown to be a useful tool for this better understanding.

Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe

This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.

High-throughput holistic preclinical screens are increasingly used in drug discovery, to assess both drug efficacy and drug safety.

Systems pharmacology aims to apply techniques from systems biology to pharmacological models.

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

On 29 October 2020, the Europa Institute Zurich organized a conference entitled «1. Zürcher Europarechtstag: Europäische Integration, Drittstaaten und (direkte) Demokratie» (1st Zurich European Law Day: European integration, third countries and (direct) democracy

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

What are the conditions under which coercive diplomacy can compel a State to abandon its nuclear weapons program?

The ERC project ‘Healthscaping Urban Europe’ will hold a concluding plenary event on 30 September, where three experts will explore the history of premodern public health and especially reflect on possible future directions within this research field. All are welcome to join in person in the Doelenzaal.…