Through metabolism, biochemical processes give rise to the complexity of life. Acquired and inborn errors in metabolism underlie many diseases occurring in man. The challenge for present day medical biochemistry is to find, and integrate, pieces of information at molecular, cell and organismal level…

The goal of hit and lead optimization is to optimize suitable chemical starting points that can modulate a drug target. The methods and technologies used are similar to those in Hit Discovery, but once the compound has shown activity in an animal model, it moves from 'hit' to 'lead.'

Meet the scientists within the LED3 community

The LED3 hub, consisting of researchers from the Leiden Institute of Chemistry (LIC), the Institute of Biology Leiden (IBL), the Leiden Academic Centre for Drug Research (LACDR) and the Leiden Institute of Advanced Computer Science (LIACS), is very excited to organize the “LED3 Lectures”. This lecture…

Recente publicaties in de Leidse handboekenreeks zullen hieronder verschijnen.

At the division of Biopharmaceutics, we aim to develop and test new therapeutic approaches to limit or even prevent the development of atherosclerosis in order to reduce the number of acute cardiovascular syndromes such as myocardial infarction or stroke.

Many metalloenzymes that are key to bioenergetics are membrane enzymes, with canonical examples the complexes I, II, III and IV in the mitochondrial inner membrane. To study these enzymes in a native-like lipid membrane environment, we aim to develop novel bioelectrochemical techniques.

The Academic Language Centre interpreting and translation service has extensive experience in translating to and from Dutch and English. Our services are characterised by professionalism, quality, and reliability.

The research program of the QO group has three leading themes: Optical Physics, Quantum Optics, and Photon-Matter Interactions. We work mostly at the boundaries between these themes with entanglement as a bridging and binding agent.

In the Psychology Lab on Wheels, we conduct innovative research together with citizens. We drive our mobile lab to people all over the country helping to bridge the gap between science and society.

The Co-Align Conference 2023 will be held on 16 May 2023 at Leiden University.

Accurately recognising others’ emotions is a fundamental social skill, relevant for navigating the social world from early childhood. Children’s ability to do represents a milestone in their socioemotional development and is associated with a number of important psychosocial outcomes. Many individual…

Do you have any questions about the master's specialisation Health and Medical Psychology? Please contact us.

Carl Li defended his thesis on 30 June 2015

Below you will find a collection of books, other than those in the BLRN book series, to which members of BLRN have contributed.

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

We study the physics of a broad range of biological and soft materials

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

Promotor: Prof.dr. J. Kuiper

Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.

Promotoren: G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.

Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Both psoriasis and atheroslcerosis are diseases characterized by a chronic and systemic inflammatory profile with local lipid disturbances that alter the barrier function of the skin (psoriasis) and cause the development of atherosclerotic plaques (atherosclerosis).

What are the functions of the endocannabinoid system?

The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: Dr. A. El Ghalbzouri

This thesis describes the design, characterization and application of dextran based crosslinked network.

Cardiovascular disease is the leading cause of death worldwide.

Human skin equivalents (HSEs) can be a valuable tool to study aspects of human skin, including the skin barrier, or to perform chemical or toxicological screenings.

Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…

Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax

Cardiovascular syndromes are the major cause of death in Western societies.

The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…

The Supramolecular & Biomaterials Chemistry group comprises the PIs Alexander Kros, Roxanne Kieltyka and Gregory Schneider, and is active in the field of self-assembly of amphiphilic peptides and applying them in supramolecular chemistry.

This was the programme for The Knowledge Orchard 2025:

Mechanical metamaterials have been found to display surprising features, on top of their unusual properties such as shape morphing and programmability. When the materials are a step in size larger, new rules seem to apply. This was discovered by researchers at AMOLF and the universities of Leiden and…

Perec’s Lieux project consists of texts describing the author's places of memory, photographs, personal documents and ephemera collected in the street.

The CIGR brings together a diverse range of unique expertise in genome research rooted in biology, chemistry and physics. Members of the CIGR investigate genome folding and genome transactions. An important aspect is direct as well as long term relevance for medicine. The available expertise extends…

In Voices on Birchbark Jos Schaeken explores the major role that writing on birchbark – an ephemeral, even ‘throw-away’ form of correspondence and administration – played in the vibrant medieval merchant city of Novgorod and other cities in the Russian Northwest.

Promotor: M.A.G.J. Orrit

The English Language and Culture study programme is also offered on a part-time basis.

Here you can sign up to our Babylab research. Each of our study investigates babies at a specific age or age range. We will contact you with details of these studies when your baby reaches the specific age. Importantly, you can always decide yourself whether you want to participate in a study or not…

Research in the Lemay Lab concentrates on Iontronics: the physics of mixed electronic-ionic charge transport.

PhD defence

On 20 februari 2019, Chris van Oostrum defended his thesis 'Regres bij concernfinanciering'. The doctoral research was supervised by Prof. mr. S.M. Bartman.

Read more about working at the Leiden University Centre for the Arts in Society (LUCAS).