On 30 November, Florian Theissen defended the thesis 'Sincerely believing in freedom: a reconstruction and comparison of the interpretation of the freedom of religion and belief on the Canadian Supreme Court, the South African Constitutional Court and the European Court of Human Rights'. The doctoral…

In the research programme Drug Discovery & Safety, we are interested in the efficacy and safety of new drugs and novel means to decipher these aspects. Hence, we employ advanced imaging and high-throughput screening techniques next to computational approaches such as chem- and bioinformatics.

In designing our programmes, we continually make the connection between theory and practice, and we guarantee an active and optimal learning process.

Promotor: Prof. dr. I. Snellen, Co-Promotor: Dr. M. Kenworthy

De opening of the Academic Year 2023-2024 took place on Monday 4 September 2023 in Pieterskerk church.

The aims of research and teaching within the Educational Sciences programme are to understand in how individuals develop and learn and to optimize education for all individuals.

If you study Pedagogical Sciences in Leiden, you will be involved in the development of young people and children and how parents, teachers and social workers can contribute to this optimally.

Source: PLoS ONE, Volume 10, Issue 3 (2015)

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

A hot topic in educational sciences is whether and how reading medium (paper vs. screen) affects reading comprehension. Especially in the media – but also in schools – their appears to be a preference for texts presented on paper: Paper texts are thought to induce a more intensive reading strategy,…

There is little evidence of the routes connecting Amerindian communities in the Caribbean prior to and just after 1492. Uncovering possible canoe routes between these communities can help to explain the structure, capabilities, and limitations of the physical links in their social and material networks.…

If a new method has been developed to recognize and treat a (neuro-)psychological disorder or related behavioral factors, it cannot yet be used directly in clinical practice. First, the method should be evaluated, preferably in randomized controlled trials.

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

Are you interested in the neurocognitive and biological roots of learning, behaviour and emotions in children? If so, the programme in Applied Neuroscience in Human Development might be the specialisation you are looking for.

The master’s specialisation Artificial Intelligence offers future-oriented topics in computer science with a focus on machine learning, optimization algorithms, and decision support techniques.

Tuberculosis (TB) is associated with 1.5 million deaths annually. There is a need exists to optimize both current as well as novel antibiotic combination treatment strategies to improve the effectiveness and safety of treatments against TB.

Lecture

At the Leiden Curious Minds Centre, our research focuses on the relationship of exploratory behaviour and discovery learning to curiosity and the way children regulate their behaviour and emotions. We want to improve our understanding of how children can and do become more and more the captain of their…

To get a feeling of how we operate at LED3 when it comes to Early Drug Discovery, please browse through our case studies. When you select a case study you’ll find relevant contacts.

Promotor: Prof.dr. C.A.M.J.J. van den Hondel, Dr. ir. V. Meyer, Co-promotor: Dr. A.F.J. Ram

Clearance is the most important pharmacokinetic parameter for drug dose selection. Pharmacokinetic information is typically first available in the adult population, and in general only limited pharmacokinetic data are available in children when drugs enter into the market. It is therefore of the utmost…

This thesis aimed to investigate core cross-linked polymeric micelles (CCPMs) and expand their potential for the delivery of hydrophobic drugs and co-factors.

In order for professionals to keep learning throughout their careers, it is necessary to be able to steer their own learning process

Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…

Steffen Brünle's group investigates G protein-coupled receptors (GPCRs). These essential membrane proteins are prime targets for therapeutic drug development in disease and cancer treatment.

Research in the natural computing group covers theoretical foundations, the development of new algorithms, and interdisciplinary applications of natural computing methods.

The Master’s specialisation Educational Science offers students cutting-edge insights into how individuals develop and learn and how education can be optimized to include every learner.

The Chemical Probe Facility is part of the Leiden Early Drug Discovery & Development (LED3) center. Activity-based protein profiling (ABPP) is one of the pillars of chemical biology. ABPP determines the activity of entire protein families in living cells and tissues under physiological conditions, such…

SuperCode: Sustainability PER AI-driven CO-DEsign

The goal of hit discovery is to identify suitable chemical starting points to modulate a drug target. A hit can be, a.o., a small molecule, a protein or mRNA. Hit identification is performed via rational design, genome mining, (targeted) library screening, or in silico approaches.

The research programme Statistical Science is concerned with the analysis and interpretation of masses of data, the quantification of uncertainty using probability models, and the development and benchmarking of algorithms and methods with these aims.

How to strike a balance between the sometimes conflicting stakes of individual, public and private data-producers and data-processors?

The research within the Division of Cell Systems and Drug Safety, headed by Prof. Bob van de Water, is focused on novel therapeutic modalities and novel concepts in early drug discovery, in order to develop more effective and safer therapeutic strategies. We generate advanced cell and computational…

Our Mission: To optimize human well-being within the constraints of planetary boundaries through innovative research, education, and partnerships that advance sustainable production and consumption. We strive to remain global leaders in developing and applying systems-based approaches, methodological…

This thesis investigates durational aspects of the Italian mobile diphthongs with respect to other rising diphthongs and monophthongs and it shows to what extent the monophthong/diphthong alternation still occurs in contemporary Italian.

Born in Europe roughly 100 years ago, quantum physics brought forth a veritable technological revolution through semiconductors, lasers, fibre optics, and many other technologies that are today ubiquitous in our lives. Now, during the second quantum revolution, Europe can take the lead once more in…

The following master research projects are currently open in the Bouwmeester group.

Do you want to learn how to prevent child problems by optimising caregiving? Would you like to advise parents, professional caregivers and policy makers on caregiving-issues? In that case the master’s specialisation Parenting and Child Development is the ideal choice for you!

Are you interested in the neurocognitive and biological roots of learning, behaviour and emotions in children? If so, the programme in Applied Neuroscience in Human Development might be the specialisation you are looking for.

Research in the POD-group addresses all features of random phenomena – modelling, structuring, analysis, control, optimisation – and covers both fundamental and applied aspects.

The Brain and Education lab is a research group in the Institute of Education and Child Studies at Leiden University in the Netherlands. We use a Developmental Cognitive Neuroscience approach to study the development of complex cognitive processes involved in learning and academic skills such as reading…

The research area of this division is focused on the development of novel therapeutic modalities and novel concepts in early drug discovery, in order to better predict ligand-target interactions.

The Dual PhD Centre facilitates dual PhD research at Leiden University. The dual PhD programme of the Dual PhD Centre offers professionals the opportunity to devote part of their working time to conducting PhD research. Be aware that this programma is being offered in Dutch only.

If you can't make it to Leiden University to visit us, don't worry. Our virtual tours take you around the cities of Leiden and The Hague, show you around on campus and into our classrooms.

This thesis advances automata learning, a key area in computer science, with applications in software verification, biological analysis, and autonomous technologies. It explores three main themes: first, it introduces a passive learning algorithm for generating compact probabilistic models from positive…