NL-BioImaging AM is a distributed research infrastructure aimed at promoting progress in the most cutting edge microscopy technologies and providing open access to these technologies to a broad community of academic and industrial users. All Netherlands bio(medical) microscopy centers participate.

In order to gain insight into the structure and function of the molecular complexes involved in chemotaxis, we use electron cryotomography (ECT). This technique allows us to directly study microbes in their native state at resolutions capable of visualizing individual proteins.

In this Ph.D. thesis we study the interaction of low energy electrons with thin materials, namely layered materials (graphene, hexagonal boron nitride, molybdenum disulfide) and organic films. At these low energies the quantum mechanical wavelength of the electron wave function is in the order of a…

The logo of Leiden University, with letters as small as a bacterium. Researchers from LUMC and the Institute of Biology have created the smallest logo of our university ever produced. It is a piece of fun with a serious real-world application: the new microscope with which the logo was made allows scientists…

Lecture

The doors of the new Gorlaeus Building are officially open! With an additional lab wing, new lecture halls and offices, a library, a brasserie, and spaces for student associations, the building offers a vibrant and inspiring environment for research, study, and social interaction. Explore on your…

A Josephson junction is a device where a thin insulating barrier or a nanostructure is placed between two superconducting leads. Such a junction is essential to superconducting qubits that store quantum information due to its anharmonic spectrum.

On this page you can find the current vacancies at the Van der Molen research group.

Three projects with Leiden researchers are to receive a subsidy from NWO for the construction or renovation of large-scale research facilities. They will be working on electron microscopy, an X-omics initiative and an X-ray telescope. The projects are part of the National Roadmap for Large-Scale Scientific…

Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.

This thesis investigates the relations between metabolism and anatomy through the use of Magnetic Resonance Imaging (MRI).

Our research in the area of safety sciences aims to increase the mechanistic understanding of cellular toxicity of drugs and, in a broader sense, chemicals.

The use of a new type of detector has generated a strong improvement in the resolution of electron microscopes. The 'low-energy electron microscope' (LEEM) can now be used for research on the thinnest possible materials. The tests with the detector represent the first result of the ESCHER project.

PhD defence

The transition to new and renewable energy sources should be completed by 2050. Researchers in various disciplines at Leiden University are conducting unique research that will help us make this transition and reduce CO2 emissions.

Physicists in Leiden have built a microscope that can measure no fewer than four key properties of a material in a single scan, all with nanoscale precision. The instrument can even examine complete quantum chips, accelerating research and innovation in the field of quantum materials.

We aim to provide new insights relating to the spectacular multi-cellular life cycle of streptomycetes and other actinobacteria.

Research groups in the Quantum Matter & Optics programme investigate electronic properties of matter and light-matter interactions with emphasis on quantum information.

Lecture, Tuesday Talk

Human and animal cells are very complex: very different chemical processes are going on at the same time, but they are separated from each other because the cells are divided in compartments. These compartments may also have a profound effect on the potential efficacy of therapeutics, because the drug…

In our lab, we investigate the physics and material properties of low-dimensional systems.

In this work, we investigate the minute circular dichroism effects of single nanoparticles.To this aim, we apply photothermal imaging with a polarization-modulated heating beam.

For each living organism health is ensured by correct functioning of its cells. Cells therefore have elaborate methods for regulation of their proteins.

In the future, physicians may be able to identify dementia much earlier than they can today because a computer algorithm will be able to predict from brain scans how our memory is going to develop.

Dementia is a progressive disease, diagnosed at a relatively late stage when intervention may not be effective. Aim of the research is to study scans of brain networks to help discover the early network changes related to dementia. Early diagnosis may benefit effectiveness of future treatment.

Graphene and other layered materials combine into completely new substances. Leiden physicists establish the ground rules for designing such materials by measuring how the layers in the stack interact. Publication on November 29 in Nature Communications.

An international team with researchers from Leiden revealed how a bacterium repurposed an internal system to control its movements. Movement control is very important in host invasion, which can lead to disease. Publication on 27 April in Nature Communications.

This project unites these two perspectives by taking a deep dive into the microstructure of historic Dutch bones. We will study human skeletal remains curated at the Faculty of Archaeology by micro-CT scanning them at LUMC facilities. With detailed micro-CT scans, we can examine bone quality in the…

Leiden research into the properties of platinum receives a TOP subsidy of 780.000 euros from the The Netherlands Organisation for Scientific Research NWO. Aim of the project is a more efficient and sustainable use of the rare metal.

Optical detection of a single electron using a single molecule has never been done. Leiden physicist Michel Orrit and his team have now identified a molecule that is sensitive enough to detect an electron at a distance of hundreds of nanometers. The results are published as a cover article in ChemPh…

Promotor: M.T.M. Koper, Co-promotors: A.I. Yanson, L.B.F. Juurlink

The Supramolecular & Biomaterials Chemistry group comprises the PIs Alexander Kros, Roxanne Kieltyka, Gregory Schneider and Sander Wezenberg, and is active in the field of self-assembly of amphiphilic peptides and applying them in supramolecular chemistry.

How can innovation help or hinder public procurement processes?

Our Division has created and maintains the Visualisation Core Facilities of the LACDR. This is a multi-user facility offering basic and advanced microscopic techniques to scientists of the LACDR.

Our facilities cover:

Smooth platinum electrodes roughen and wear when subjected to repeated cycles of oxidation and reduction, which causes nanometer-scale mounds to grow. Leiden chemists Leon Jacobse and Marc Koper, together with physicist Marcel Rost, discovered the exact details, using a unique tunneling microscope.

Tuberculosis causes 1.5 million deaths yearly and anti-tuberculosis therapies are threatened by emergence of drug resistance. Development of innovative drug combinations should be accelerated with the use of translational pharmacological models. Moreover, host-directed therapies (HDT), which stimulate…

The quantum nature of matter and light has grown into a broad and fruitful research field for theorists and experimentalists alike. It combines foundational research with toward applications, the most well known of which is the quantum computer.

The rapid advances in imaging technology enable to see inside the body with ever increasing detail.

In this thesis, time-lapse fluorescent microscopy plays a pivotal role in investigating functional materials within living cells as well as the migratory behaviour of neural progenitor cells.

Steffen Brünle's group investigates G protein-coupled receptors (GPCRs). These essential membrane proteins are prime targets for therapeutic drug development in disease and cancer treatment.

X-Ray Diffraction (XRD), Nuclear Magnetic Resonance (NMR) and Cryo-electron microscopy (Cryo-EM) are the three main methods for solving structures of macromolecules.

High-temperature superconductivity is one of the big mysteries in physics. Milan Allan’s research group used a Josephson Scanning Tunneling Microscope to image spatial variations of superconducting particles for the first time, and published about it in the journal Nature.