The aim of the research described in this thesis was to use structure-based design to optimise multiple properties of aryl sulfoxide monoacylglycerol lipase inhibitors as anti-inflammatory analgesics.

How do museum visitors interpret the authenticity of museum objects? How can we support visitors' meaningful interactions with real objects?

This thesis advance our understanding and the application of molecular catalysts relevant to the reduction of oxygen as well as reduction of nitrite.

The Data-Driven Drug Discovery Network (D4N) is an initiative by researchers from Leiden University and collaborators to join efforts in applying and developing novel techniques from data science to drug discovery and related topics from bioinformatics.

To be eligible for Chemistry at Leiden University, you must meet the following admission requirements.

Research and design are becoming more and more important in international science education. In The Netherlands, two recently introduced subjects focus on research and design activities in the classroom: O&O (research and design) and NLT (nature, life and technology). This research aims to look at what…

The concept behind GraspOS is to build the European Federated Open Metrics Infrastructure in a decentralised way, where: different types of data come together to create metrics; tools and services are developed to improve EU or global infrastructures but are also shared with national or institutional…

Since May, Assistant professor BioTherapeutics Lu Su works in our faculty. Although she is still young, she already worked in many different fields and co-operated on two publications in big scientific journals. How did she become so successful and what motivates her to keep researching the possibilities…

Heterogeneous catalyzed processes are highly significant to the chemical industry. Dissociative chemisorption (DC) of molecules on surfaces is always considered as a step with a high degree of rate control for heterogeneous catalysis.

The ability to collect and interpret huge quantities of data has become indispensable to society and academia. Leiden University is a knowledge and expertise centre for data science that places the emphasis on interdisciplinary collaboration and innovation.

From where litter ends up to which languages are spoken in Leiden and The Hague: over 50 interesting, surprising, complex and entertaining questions were sent in for the Citizen Science project to mark our 444th anniversary. Not one but two Citizen Science projects will be starting this year in Leiden…

On this page you find all the ways through which the Institute of Psychology aims to foster Open Science.

Citizen science has recently become a widely used term, but what does it mean exactly? How does citizen science compare to crowdsourcing? And where does community archaeology stand in this discussion?

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Global healthcare is on the verge of an antibiotic availability crisis as bacteria have evolved resistance to nearly all known antibacterials. Identifying new antibiotics that operate via novel modes-of-action is therefore of high priority.

The majority of scientists, from archaeologists through to zoologists, collect enormous volumes of data. Their massive databases contain large amounts of information which is difficult for humans to filter. With a solid grounding in statistics and computer science, we can develop algorithms for analyzing…

The Institute of Political Science is a vibrant department with nearly 70 academic staff in Leiden and nearby The Hague.

Are you thinking about studying Biomedical Sciences? Learn more and watch a short promo video.

Despite the history of studies on methanol formation from CO2, the dominant elementary reaction steps that constitute the chemical mechanism for this catalyzed process are not determined.

Computational thinking, programming, and algorithms form the basic of many of the things that are shaping our world, the way we work, interact, organize ourselves, and even spend our free time with social networks, streaming media, and games. And this transformation is far from being complete, it is…

BE-OPEN is a structural project funded under the Erasmus+ Capacity Building in Higher Education action. The project is coordinated by the University of Novi Sad, Serbia. The main objective of the project is to develop conditions for the implementation of the core principles of Open Science at universities…

Are you thinking about studying Political Science? Watch the introduction video’s and learn more!

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

This thesis describes a study from both a theoreticaL and an experimental point of view.

The majority of scientists, from archaeologists through to zoologists, collect huge volumes of data. Their massive databases contain large amounts of information which is difficult for humans to filter. With a solid grounding in statistics, we can develop algorithms for analysing and identifying patterns…

Are you thinking about studying Computer Science? Learn more and watch the videos. Note: As of September 2025 you can also combine this master programme with the Business Studies specialisation.

In Microbial Sciences, we perform multidisciplinary research to understand the structure and function of microbes at all levels of biological organization, from small molecules and cellular structures at atomic resolution to multicellular communities.

Leiden University will be recording a brand-new series of podcasts in 2019: Science Shots. Our top scientists will talk about their research in less than 15 minutes. Tip: something to enjoy on the train journey between Leiden and The Hague, our two University cities!

The Department of Archaeological Sciences seeks to achieve the highest standards of excellence in science-driven education and archaeological research across the globe and across all periods.

PhD candidates carry out a programme of independent research and additional (limited) course work, culminating in production of a PhD thesis in typically 4 years.

The master’s specialisation Bio-Pharmaceutical Sciences and Science Communication & Society at Leiden University is a two-year programme which combines research training in chemistry with one in techniques of communication.

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

The formation and evolution of galaxies is fundamentally driven by the formation of new stars out of cold gas.

Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.

Overkleeft

With the emergence of new methods and technologies such as improved DNA analysis and big data, archaeological research has changed radically in recent decades. The researchers from the Department of Archaeological Sciences at the Faculty of Archaeology use new scientific knowledge to answer fundamental…

At the Institute of Political Science we value our alumni. We can learn from you, and would like to contribute to your further development. And, of course, we want to lend a hand in connecting ‘our’ political scientists all over the world.

PhD candidates carry out a programme of independent research and additional (limited) course work, culminating in production of a PhD thesis in typically 4 years.

PhD candidates carry out a programme of independent research, leading to a PhD thesis in typically 4 years.

Engineering an efficient microbial enzymatic polyethylene degradation pathway via an innovative combination of biochemistry and computational biology tools for enzyme discovery and characterization.

This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.